PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZHX1	1	ZHX3	1	two hybrid, two hybrid, pull down	Yamada K (2003), Yamada K (2003), Yamada K (2003)	3
ATXN1	2	ZHX3	1	two hybrid	Lim J (2006)	1
SH2D2A	2	ZHX3	1	two hybrid	Grossmann A (2015)	1
ZHX3	1	ZHX3	1	two hybrid, pull down	Yamada K (2003), Yamada K (2003)	2
ZHX1	1	ZHX2	3	affinity chromatography technology	Hein MY (2015)	1
ATXN1	2	NLK	1	two hybrid	Lim J (2006)	1
PDIA6	1	ZHX3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EWSR1	2	ZHX3	1	bioid	Elzi DJ (2014)	1
TFAP4	3	ZHX3	1	affinity chromatography technology	Ku WC (2009)	1
EWSR1	2	PDIA6	1	bioid	Elzi DJ (2014)	1
ATXN1	2	ZHX2	3	two hybrid	Lim J (2006)	1
WDYHV1	0	ZHX3	1	affinity chromatography technology	Huttlin EL (2017)	1
ZHX3	1	NLK	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZHX2	3	ZHX3	1	pull down, pull down, two hybrid	Kawata H (2003), Kawata H (2003), Kawata H (2003)	3
ZHX1	1	ATXN1	2	two hybrid, two hybrid, affinity chromatography technology	Yamada K (2003), Lim J (2006), Lim J (2006)	3