PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CXXC1	3	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	12
ASH2L	2	DPY30	1	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid	Rual JF (2005), Mak AB (2010), Chen Y (2012), Rolland T (2014), Yu H (2011)	5
SETD1B	15	RBM26	3	affinity chromatography technology	Hein MY (2015)	1
WDR5	2	SETD1A	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lee JH (2005), Lee JH (2007), Lee JH (2007), Mak AB (2010), Dharmarajan V (2012), Zhang P (2012), Zhang P (2012), Kim J (2013), Tang Z (2013), Huttlin EL (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016), Hauri S (2016)	14
WDR82	3	DPY30	1	affinity chromatography technology	Tang Z (2013)	1
SETD1B	15	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lee JH (2007), Lee JH (2007), Lee JH (2007), Dharmarajan V (2012), Zhang P (2012), Zhang P (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016), Hauri S (2016)	12
SETD1B	15	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lee JH (2007), Lee JH (2007), Lee JH (2007), Lee JH (2010), Hein MY (2015), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016)	7
CXXC1	3	HIST2H3C	0	affinity chromatography technology	Ansari KI (2008)	1
SETD1A	12	SETD1B	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2007), Lee JH (2007), Lee JH (2007)	3
WDR82	3	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Tang Z (2013), Hauri S (2016)	4
SETD1B	15	ZC3H3	4	affinity chromatography technology	Hein MY (2015)	1
SETD1B	15	HIST1H3E	0	enzymatic study	Lee JH (2007)	1
SETD1B	15	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lee JH (2008), Mak AB (2010), Hein MY (2015), Li Y (2016), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016)	6
FOXK2	9	DPY30	1	affinity chromatography technology	Li X (2015)	1
ASH2L	2	HIST1H3A	3	enzymatic study	Pavri R (2006)	1
WDR5	2	DPY30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Bailey JK (2015), Hauri S (2016)	3
SETD1B	15	WBP4	0	affinity chromatography technology	Hein MY (2015)	1
CXXC1	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Tang Z (2013), Hein MY (2015), Huttlin EL (2017)	12
PRMT2	3	SETD1A	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CXXC1	3	SETD1B	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Butler JS (2008), Lee JH (2007), Lee JH (2007), Lee JH (2007), Havugimana PC (2012), Tang Z (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016)	11
WDR82	3	5430	0	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010)	2
CDK9	3	5430	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Moisan A (2006), Yoh SM (2007), Benedikt A (2011), Gegonne A (2008), Friedl EM (2003), He N (2011), Pinhero R (2004), Ramanathan Y (2001), Chen R (2004), Larochelle S (2012), Bharucha DC (2002), Kim YK (2002), Garriga J (2003), Wu L (2014), Yik JH (2003), Pinhero R (2004), Shchebet A (2012), Rovnak J (2012), Baumli S (2008), Yik JH (2005), Yik JH (2004)	21
PRMT2	3	CXXC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3A	3	WDR5	2	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006), Schuetz A (2006), Couture JF (2006), Ruthenburg AJ (2006), Han Z (2006), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Bailey JK (2015)	11
SETD1A	12	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Lee JH (2005), Lee JH (2008), Mak AB (2010), Li X (2011), Havugimana PC (2012), Kim J (2013), Tang Z (2013), Tang Z (2013), Li Y (2016), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016)	11
CXXC1	3	WDR82	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Butler JS (2008), Lee JH (2010), Lee JH (2010), Kim J (2009), Tang Z (2013), Tang Z (2013)	7
SETD1B	15	DPY30	1	affinity chromatography technology	Hein MY (2015)	1
PIP4K2A	0	CXXC1	3	affinity chromatography technology	Huttlin EL (2017)	1
RBBP5	3	DPY30	1	affinity chromatography technology	Mak AB (2010)	1
CDK9	3	SYNCRIP	6	affinity chromatography technology	Jeronimo C (2007)	1
FOXK2	9	SETD1B	15	affinity chromatography technology, affinity chromatography technology, biochemical	Shan L (2016), Shan L (2016), Shan L (2016)	3
PRMT2	3	SETD1B	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
SETD1A	12	HIST2H3C	0	enzymatic study	Zhang P (2012)	1
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
SETD1B	15	5430	0	affinity chromatography technology	Lee JH (2008)	1
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
CDK9	3	SETD1B	15	biochemical	Havugimana PC (2012)	1
SETD1A	12	WDR82	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2007), Lee JH (2007), Lee JH (2008), Lee JH (2008), Lee JH (2010), Lee JH (2010), Lee JH (2010), Tang Z (2013), Tang Z (2013), Alicea-Velazquez NL (2016)	10
CXXC1	3	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Hein MY (2015), Huttlin EL (2017)	11
SETD1A	12	DPY30	1	pull down, affinity chromatography technology	Kim J (2013), Tang Z (2013)	2
WDR82	3	SETD1B	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2007), Lee JH (2010), Lee JH (2010), Lee JH (2010), Tang Z (2013), Alicea-Velazquez NL (2016)	6
SETD1B	15	MVD	2	affinity chromatography technology	Hein MY (2015)	1
CXXC1	3	DPY30	1	affinity chromatography technology, affinity chromatography technology	Tang Z (2013), Hein MY (2015)	2
SETD1A	12	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Lee JH (2005), Lee JH (2007), Lee JH (2007), Lee JH (2008), Lee JH (2010), Mersman DP (2012), Mak AB (2010), Li X (2011), Havugimana PC (2012), Kim J (2013), Tang Z (2013), Alicea-Velazquez NL (2016), Alicea-Velazquez NL (2016)	13
RBBP5	3	HIST2H3C	0	pull down	Goo YH (2003)	1
WDR82	3	RBBP5	3	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Tang Z (2013)	2
CXXC1	3	SETD1A	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ansari KI (2008), Ansari KI (2008), Tate CM (2009), Lee JH (2005), Lee JH (2005), Lee JH (2005), Butler JS (2008), Lee JH (2007), Lee JH (2007), Tate CM (2010), Lee JH (2008), Kim J (2009), Kim J (2013), Tang Z (2013), Tang Z (2013), Hein MY (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016)	18
SETD1B	15	HIST1H3A	3	enzymatic study	Tang Z (2013)	1
FOXK2	9	RBM26	3	affinity chromatography technology	Li X (2015)	1
FOXK2	9	RBBP5	3	affinity chromatography technology	Li X (2015)	1
SETD1B	15	HIST2H3C	0	enzymatic study	Zhang P (2012)	1
SETD1A	12	5430	0	affinity chromatography technology	Lee JH (2008)	1
PIP4K2A	0	SETD1B	15	affinity chromatography technology	Huttlin EL (2017)	1
SETD1A	12	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study	Kim J (2009), Kim J (2013), Tang Z (2013)	3
SYNCRIP	6	SETD1B	15	affinity chromatography technology	Hein MY (2015)	1
WDR82	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Tang Z (2013), Tang Z (2013)	4