PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CACNA1A	21	UBE2L3	1	affinity chromatography technology	Gandini MA (2014)	1
USP7	14	HECW1	3	two hybrid	Lim J (2006)	1
HECW1	3	HECW1	3	enzymatic study	Zhang W (2016)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
MPHOSPH8	1	HECW1	3	affinity chromatography technology	Hein MY (2015)	1
HECW1	3	UBE2D3	1	pull down	Kristariyanto YA (2015)	1
UBE2J2	1	UBC	7	enzymatic study	Sheng Y (2012)	1
TP53	0	TNK2	7	affinity chromatography technology	Ding G (2013)	1
LDLRAD4	1	HECW1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM189B	2	HECW1	3	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
HECW1	3	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
RNF43	5	HECW1	3	two hybrid, affinity chromatography technology	Shinada K (2011), Shinada K (2011)	2
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
CACNA1A	21	HECW1	3	two hybrid	Kahle JJ (2011)	1
HECW1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
TP53	0	HECW2	13	affinity chromatography technology	Miyazaki K (2003)	1
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
HECW1	3	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
HECW1	3	UBE2J2	1	pull down	Zhang W (2016)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
HECW1	3	DVL1	5	two hybrid, affinity chromatography technology	Miyazaki K (2004), Miyazaki K (2004)	2
FAM189B	2	HECW2	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HECW2	13	HECW1	3	affinity chromatography technology	Lu L (2013)	1
GFI1B	1	HECW1	3	two hybrid	Lim J (2006)	1
HECW1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
SOD1	0	SSR4	1	affinity chromatography technology	Miyazaki K (2004)	1
UBC	7	FBXL15	0	pull down	Zhang X (2017)	1
LDLRAD4	1	HECW2	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	RNF43	5	two hybrid, pull down	van Wijk SJ (2009), Sugiura T (2008)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HECW1	3	TNK2	7	pull down	Chan W (2009)	1
HECW2	13	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
HECW2	13	UBE2L3	1	pull down, pull down	Miyazaki K (2003), Zhang W (2016)	2
HECW2	13	UBE2D3	1	pull down	Miyazaki K (2003)	1
SOD1	0	UBE2L3	1	biochemical	Wan C (2015)	1
SOD1	0	UBC	7	affinity chromatography technology	Urushitani M (2004)	1
UBE2D1	0	RNF43	5	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
SSR4	1	HECW1	3	affinity chromatography technology	Miyazaki K (2004)	1
HECW1	3	UBE2L3	1	pull down	Kristariyanto YA (2015)	1
SOD1	0	HECW1	3	affinity chromatography technology	Miyazaki K (2004)	1
UBE2D3	1	RNF43	5	two hybrid, pull down	van Wijk SJ (2009), Sugiura T (2008)	2
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
SCNN1B	1	HECW1	3	far western blotting	Harvey KF (2001)	1
SCNN1A	1	HECW1	3	far western blotting	Harvey KF (2001)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
HECW1	3	TP53	0	affinity chromatography technology, pull down	Li Y (2008), Li Y (2008)	2
TP53	0	RNF43	5	affinity chromatography technology, affinity chromatography technology	Shinada K (2011), Shinada K (2011)	2