PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF423	14	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Hata A (2000), Bond HM (2004)	2
RBBP7	1	ZNF423	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	ZNF423	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LYN	2	ZNF423	14	affinity chromatography technology	Zhu J (2013)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
MTA1	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Huttlin EL (2015), Huttlin EL (2017), Millard CJ (2016), Hauri S (2016)	6
ZNF423	14	EBF2	4	biochemical	Tsai RY (1997)	1
MBD3L1	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang CL (2004), Huttlin EL (2015), Huttlin EL (2017)	3
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
RBBP7	1	BRCA1	7	affinity chromatography technology, two hybrid, pull down, far western blotting, pull down	Chen GC (2001), Chen GC (2001), Yarden RI (2001), Yarden RI (2001), Yarden RI (1999)	5
USP7	14	ZNF423	14	two hybrid	Lim J (2006)	1
ZNF219	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF423	14	PARP1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ku MC (2003), Ku MC (2003), Chaki M (2012), Chaki M (2012)	4
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
ZNF219	3	ZNF423	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTA1	3	ZNF423	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP290	5	ZNF423	14	two hybrid, affinity chromatography technology	Chaki M (2012), Chaki M (2012)	2
ZNF423	14	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Hata A (2000), Bond HM (2004)	2
MBD3L1	0	ZNF219	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang CL (2004), Huttlin EL (2015), Huttlin EL (2017)	3
EBF1	1	ZNF423	14	biochemical, biochemical, affinity chromatography technology	Tsai RY (1997), Tsai RY (1997), Tsai RY (1997)	3
ZNF423	14	EBF3	9	biochemical	Tsai RY (1997)	1
ZNF423	14	BRCA1	7	two hybrid	Hill SJ (2014)	1
ZG16B	0	ZNF423	14	affinity chromatography technology	Huttlin EL (2017)	1
ZNF219	3	MTA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2