PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
MED4	2	CCDC14	2	bioid	Lambert JP (2015)	1
VWCE	5	TTLL5	5	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	TP53	0	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
TP53	0	TTLL5	5	affinity chromatography technology	Lunardi A (2010)	1
MED4	2	FGFR1OP	0	bioid	Lambert JP (2015)	1
CEP135	2	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1
TP73	2	TTLL5	5	affinity chromatography technology	Lunardi A (2010)	1
OFD1	3	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CCDC14	2	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1
CEP135	2	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CCDC14	2	FGFR1OP	0	bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Hein MY (2015), Hein MY (2015)	3
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
MED4	2	TTLL5	5	bioid	Lambert JP (2015)	1
CEP135	2	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
OFD1	3	TP53	0	affinity chromatography technology	Gupta GD (2015)	1
MED4	2	OFD1	3	bioid	Lambert JP (2015)	1
TP53	0	PTTG1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bernal JA (2002), Bernal JA (2002), Bernal JA (2002), Kim HS (2009)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PTTG1	0	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1
TTC25	0	TTLL5	5	affinity chromatography technology	Huttlin EL (2017)	1
CACNG5	0	TTLL5	5	affinity chromatography technology	Huttlin EL (2017)	1
FGFR1OP	0	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1
OFD1	3	FGFR1OP	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Hein MY (2015)	3
CEP128	1	TTLL5	5	bioid	Gupta GD (2015)	1
PCM1	5	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP128	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
THBS3	3	TTLL5	5	affinity chromatography technology	Huttlin EL (2015)	1
CEP128	1	CCDC14	2	bioid	Gupta GD (2015)	1
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PCM1	5	TTLL5	5	bioid	Gupta GD (2015)	1
CREB3	1	TTLL5	5	two hybrid, two hybrid	Eleveld-Trancikova D (2010), Eleveld-Trancikova D (2010)	2
CCDC14	2	OFD1	3	bioid, bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015), Hein MY (2015)	4
CEP135	2	TP53	0	bioid	Gupta GD (2015)	1
GAR1	0	TTLL5	5	affinity chromatography technology	Hein MY (2015)	1