PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT7	1	APP	1	pull down	Olah J (2011)	1
CBX5	3	POGZ	49	affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Nozawa RS (2010), Nozawa RS (2010), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	7
VAV2	6	POGZ	49	two hybrid	Thalappilly S (2008)	1
CBX3	1	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
NRF1	2	POGZ	49	two hybrid	Rolland T (2014)	1
POU2F1	5	POGZ	49	two hybrid	Rolland T (2014)	1
MOV10	6	NFYA	2	affinity chromatography technology	Castello A (2012)	1
POGZ	49	BANP	1	two hybrid	Rolland T (2014)	1
ZXDC	1	APP	1	pull down	Olah J (2011)	1
DAZAP2	1	POGZ	49	two hybrid	Rolland T (2014)	1
CBX1	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3
FOXJ2	3	NRF1	2	affinity chromatography technology	Li X (2015)	1
CBX1	0	MAD2L2	0	affinity chromatography technology	Hauri S (2016)	1
NFYA	2	APP	1	pull down	Olah J (2011)	1
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
NXF1	0	MAD2L2	0	affinity chromatography technology	Castello A (2012)	1
RBPMS	0	BANP	1	two hybrid	Rolland T (2014)	1
SIRT7	1	MOV10	6	affinity chromatography technology	Tsai YC (2012)	1
DAZAP2	1	PRR20A	0	two hybrid	Rolland T (2014)	1
SIRT7	1	POGZ	49	affinity chromatography technology	Tsai YC (2012)	1
MAD2L2	0	CHAMP1	8	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015)	2
CD4	1	HGS	5	affinity chromatography technology	Barriere H (2007)	1
SP1	0	NFYA	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roder K (1999), Roder K (1999), Roder K (1999), Roder K (1999), Wang W (1999)	5
SP1	0	CBX5	3	pull down	Marban C (2005)	1
FOXJ2	3	ZMYM4	4	affinity chromatography technology	Li X (2015)	1
HGS	5	POGZ	49	two hybrid	Rolland T (2014)	1
MDC1	8	CHAMP1	8	affinity chromatography technology	Woods NT (2012)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
DAB1	1	APP	1	pull down, pull down	Homayouni R (1999), Olah J (2011)	2
TMEM171	1	POGZ	49	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	POGZ	49	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	SP1	0	affinity chromatography technology	Castello A (2012)	1
FOXJ2	3	APP	1	pull down	Olah J (2011)	1
NFYC	0	NFYA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Yun J (2003), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
FOXJ2	3	RNF2	1	affinity chromatography technology	Li X (2015)	1
EED	1	POGZ	49	affinity chromatography technology	Cao Q (2014)	1
EED	1	MDC1	8	affinity chromatography technology	Cao Q (2014)	1
CD4	1	NR3C1	2	affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Loewenberg M (2006)	2
FOXJ2	3	NFYC	0	affinity chromatography technology	Li X (2015)	1
HIST3H3	0	ZMYM4	4	unspecified method	Vermeulen M (2010)	1
POGZ	49	ZMYM4	4	affinity chromatography technology	Vermeulen M (2010)	1
NR3C1	2	CREB1	1	pull down, affinity chromatography technology	Imai E (1993), Guo C (2010)	2
FOXJ2	3	POGZ	49	affinity chromatography technology	Li X (2015)	1
EED	1	HIST3H3	0	unspecified method, x-ray crystallography	Xu C (2010), Xu C (2010)	2
DAB1	1	PRR20A	0	two hybrid	Rolland T (2014)	1
POGZ	49	PRR20A	0	two hybrid	Rolland T (2014)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
FOXQ1	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
CREB1	1	POGZ	49	two hybrid	Bandyopadhyay S (2010)	1
SIRT7	1	CBX3	1	affinity chromatography technology	Tsai YC (2012)	1
NXF1	0	HGS	5	affinity chromatography technology	Castello A (2012)	1
NFYC	0	POGZ	49	two hybrid	Bandyopadhyay S (2010)	1
CHAMP1	8	ZMYM4	4	affinity chromatography technology	Hein MY (2015)	1
CBX5	3	HIST3H3	0	affinity chromatography technology, unspecified method, x-ray crystallography, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	Quivy JP (2004), Kaustov L (2011), Kaustov L (2011), Bartke T (2010), Li X (2012), Li X (2012), Vermeulen M (2007), Kubota S (2013), Vermeulen M (2010), Vermeulen M (2010), Lacroix M (2008)	11
HGS	5	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MDC1	8	CBX3	1	affinity chromatography technology	Woods NT (2012)	1
GABPB1	0	POGZ	49	two hybrid	Rolland T (2014)	1
NFATC2	1	CHAMP1	8	affinity chromatography technology	Gabriel CH (2016)	1
SUMO2	0	POGZ	49	pull down	Ouyang J (2009)	1
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HIST3H3	0	CBX1	0	unspecified method, unspecified method, affinity chromatography technology, unspecified method	Kaustov L (2011), Pichler G (2012), Pichler G (2012), Vermeulen M (2010)	4
CBX1	0	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
LCOR	4	POGZ	49	affinity chromatography technology	Huttlin EL (2017)	1
NFATC2	1	POGZ	49	affinity chromatography technology	Gabriel CH (2016)	1
EED	1	NXF1	0	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	HIST3H3	0	affinity chromatography technology, unspecified method	Trojer P (2011), Vermeulen M (2010)	2
NFATC2	1	CBX3	1	affinity chromatography technology	Gabriel CH (2016)	1
NXF1	0	ZMYM4	4	affinity chromatography technology	Castello A (2012)	1
NFATC2	1	NFYC	0	affinity chromatography technology	Gabriel CH (2016)	1
RNF2	1	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hauri S (2016), Hauri S (2016)	4
EED	1	ENO1	3	affinity chromatography technology	Cao Q (2014)	1
MOV10	6	HGS	5	affinity chromatography technology	Castello A (2012)	1
ZNF428	1	POGZ	49	affinity chromatography technology	Huttlin EL (2017)	1
SIRT7	1	NXF1	0	affinity chromatography technology	Tsai YC (2012)	1
SP1	0	POGZ	49	pull down	Gunther M (2000)	1
CREB1	1	NFYA	2	affinity chromatography technology	Li X (2015)	1
POGZ	49	MAD2L2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Vermeulen M (2010), Hein MY (2015)	3
CBX3	1	POGZ	49	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosnoblet C (2011), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016)	4
FOXJ2	3	NR3C1	2	affinity chromatography technology	Li X (2015)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
NXF1	0	NFYA	2	affinity chromatography technology	Castello A (2012)	1
SUMO2	0	CHAMP1	8	pull down	Ouyang J (2009)	1
FOXG1	26	MOV10	6	affinity chromatography technology	Li X (2015)	1
HIST3H3	0	CHAMP1	8	unspecified method	Vermeulen M (2010)	1
CBX1	0	ZMYM4	4	affinity chromatography technology	Hauri S (2016)	1
DAB1	1	POGZ	49	two hybrid	Rolland T (2014)	1
NXF1	0	ZXDC	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	POGZ	49	affinity chromatography technology	Castello A (2012)	1
SIRT7	1	XPO1	8	affinity chromatography technology	Tsai YC (2012)	1
TMEM171	1	CHAMP1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ENO1	3	POGZ	49	affinity chromatography technology	Castello A (2012)	1
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
NFATC2	1	CBX1	0	affinity chromatography technology	Gabriel CH (2016)	1
USP37	1	POGZ	49	bioid	Yeh C (2015)	1
POGZ	49	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Vermeulen M (2010), Hein MY (2015)	3
USP37	1	CBX3	1	bioid	Yeh C (2015)	1
POU2F1	5	CREB1	1	affinity chromatography technology, pull down, pull down	Boulon S (2002), Boulon S (2002), Boulon S (2002)	3
CREB1	1	HIST3H3	0	affinity chromatography technology	Li X (2015)	1
HIST3H3	0	CBX3	1	unspecified method, x-ray crystallography, unspecified method	Kaustov L (2011), Kaustov L (2011), Vermeulen M (2010)	3
LCOR	4	EED	1	affinity chromatography technology	Hauri S (2016)	1
POU2F1	5	APP	1	pull down	Olah J (2011)	1
RNF2	1	MOV10	6	affinity chromatography technology	Cao Q (2014)	1
HIST3H3	0	POGZ	49	affinity chromatography technology, unspecified method	Vermeulen M (2010), Vermeulen M (2010)	2
SUMO2	0	ENO1	3	pull down	Ouyang J (2009)	1
FOXQ1	0	POGZ	49	affinity chromatography technology	Li X (2015)	1
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
MOV10	6	POGZ	49	affinity chromatography technology	Castello A (2012)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
CDK6	0	POGZ	49	enzymatic study	Anders L (2011)	1
CDK6	0	DAB1	1	two hybrid	Rolland T (2014)	1
NFYC	0	SP1	0	two hybrid	Bandyopadhyay S (2010)	1
RNF2	1	POGZ	49	affinity chromatography technology	Cao Q (2014)	1
MDC1	8	ENO1	3	affinity chromatography technology	Woods NT (2012)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
ING4	1	HIST3H3	0	x-ray crystallography, pull down	Palacios A (2006), Varier RA (2010)	2
ING4	1	POGZ	49	affinity chromatography technology	Hein MY (2015)	1
ZNF576	2	POGZ	49	affinity chromatography technology	Huttlin EL (2017)	1
POGZ	49	HDGFL2	3	affinity chromatography technology	Vermeulen M (2010)	1
MAD2L2	0	CBX3	1	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2
SUMO2	0	ZMYM4	4	pull down	Ouyang J (2009)	1
NR3C1	2	POGZ	49	bioid	Lempiaeinen JK (2017)	1
NFATC2	1	CBX5	3	affinity chromatography technology	Gabriel CH (2016)	1
RNF2	1	CBX1	0	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Hauri S (2016)	2
RBPMS	0	PRR20A	0	two hybrid	Rolland T (2014)	1
RBPMS	0	POGZ	49	two hybrid	Rolland T (2014)	1
MAD2L2	0	CBX5	3	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2
CD4	1	ENO1	3	affinity chromatography technology	Bernhard OK (2004)	1
CBX5	3	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	4
CD4	1	POGZ	49	affinity chromatography technology	Huttlin EL (2017)	1
CHAMP1	8	HDGFL2	3	affinity chromatography technology	Hein MY (2015)	1
POGZ	49	ZXDC	1	two hybrid	Rolland T (2014)	1
ZBTB24	1	POGZ	49	two hybrid	Rolland T (2014)	1
POGZ	49	APP	1	pull down	Olah J (2011)	1
SP1	0	POU2F1	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Stroem AC (1996), Stroem AC (1996), Gunther M (2000), Lim K (2009), Lim K (2009)	5
POU2F1	5	NR3C1	2	pull down, pull down, pull down, affinity chromatography technology	Prefontaine GG (1999), Wang JM (1999), Prefontaine GG (1998), Prefontaine GG (1998)	4
FOXG1	26	POGZ	49	affinity chromatography technology	Li X (2015)	1
MOV10	6	MAD2L2	0	affinity chromatography technology	Castello A (2012)	1
MDC1	8	POGZ	49	affinity chromatography technology	Woods NT (2012)	1
SIRT7	1	MDC1	8	affinity chromatography technology	Tsai YC (2012)	1
EED	1	CBX3	1	affinity chromatography technology	Cao Q (2014)	1
CREB1	1	NFATC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
MOV10	6	ZMYM4	4	affinity chromatography technology	Castello A (2012)	1
CHAMP1	8	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3
NFYA	2	POGZ	49	two hybrid	Rolland T (2014)	1
RNF2	1	XPO1	8	affinity chromatography technology	Cao Q (2014)	1
ZNF428	1	CHAMP1	8	affinity chromatography technology	Huttlin EL (2017)	1