PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FLI1	2	SOX30	2	two hybrid	Rolland T (2014)	1
SMAD9	0	KAT2B	2	affinity chromatography technology	Kahata K (2004)	1
FLI1	2	SIAH1	2	two hybrid	Rolland T (2014)	1
KLF1	1	FLI1	2	affinity chromatography technology, pull down	Starck J (2003), Starck J (2003)	2
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
FLI1	2	SMAD3	1	two hybrid	Ravasi T (2010)	1
PIAS1	4	FLI1	2	enzymatic study	van den Akker E (2005)	1
ELK1	2	SRF	1	pull down, pull down	Watson DK (1997), Pingoud V (1994)	2
SIAH1	2	PIAS1	4	two hybrid, pull down, affinity chromatography technology	Depaux A (2007), Depaux A (2007), Lee JH (2016)	3
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
CTBP2	7	UBE2I	0	two hybrid	Wang J (2011)	1
SMAD3	1	KAT2B	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012)	5
ELK1	2	FLI1	2	pull down	Watson DK (1997)	1
KAT2B	2	CTBP2	7	affinity chromatography technology	Shimahara A (2010)	1
SMAD9	0	FLI1	2	two hybrid	Colland F (2004)	1
FLI1	2	UBE2I	0	two hybrid	van den Akker E (2005)	1
UBE2I	0	ELK1	2	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Yang SH (2006), Yang SH (2006), Yang SH (2006), Yang SH (2003), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013)	7
PRKCD	2	FLI1	2	enzymatic study, affinity chromatography technology	Asano Y (2009), Asano Y (2009)	2
FLI1	2	SRF	1	pull down	Dalgleish P (2000)	1
ETV6	1	UBE2I	0	two hybrid, pull down	Chakrabarti SR (1999), Chakrabarti SR (1999)	2
ETV6	1	FLI1	2	two hybrid, pull down, affinity chromatography technology	Kwiatkowski BA (1998), Kwiatkowski BA (1998), Kwiatkowski BA (1998)	3
FLI1	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Asano Y (2007), Asano Y (2009)	2
BRCA1	7	PIAS1	4	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
BRCA1	7	SOX30	2	two hybrid	Woods NT (2012)	1
CTBP2	7	FLI1	2	two hybrid	Rolland T (2014)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
SIAH1	2	PIAS2	2	two hybrid	Depaux A (2007)	1
UBE2I	0	SRF	1	enzymatic study	Matsuzaki K (2003)	1
SMAD3	1	SMAD9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIAS2	2	SMAD3	1	pull down	Li X (2006)	1
BRCA1	7	FLI1	2	pull down	Chai Y (2001)	1
FMNL1	3	FLI1	2	affinity chromatography technology	Han Y (2013)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
FLI1	2	PIAS2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	van den Akker E (2005), van den Akker E (2005), van den Akker E (2005), van den Akker E (2005), van den Akker E (2005)	5
FLI1	2	GATA1	1	two hybrid, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down	Eisbacher M (2003), Eisbacher M (2003), Eisbacher M (2003), Starck J (2003), Starck J (2003), Starck J (2003), Rekhtman N (1999)	7