PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAD54L2	5	KHSRP	5	biochemical	Wan C (2015)	1
ATXN1	2	RAD54L2	5	two hybrid	Lim J (2006)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
UBE2I	0	NR5A2	4	enzymatic study, enzymatic study	Yang SH (2006), Ogawa H (2009)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
SQSTM1	0	TAX1BP1	3	affinity chromatography technology	Mildenberger J (2017)	1
ATN1	2	RAD54L2	5	two hybrid	Lim J (2006)	1
RAD54L2	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, x-ray crystallography	Tsuchiya M (2015), Tsuchiya M (2015), Tsuchiya M (2015), Tsuchiya M (2015), Tsuchiya M (2015), Tsuchiya M (2015)	6
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
ATXN1L	0	RBPMS	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
SIAH1	2	PIAS1	4	two hybrid, pull down, affinity chromatography technology	Depaux A (2007), Depaux A (2007), Lee JH (2016)	3
RAD54L2	5	NR3C1	2	pull down	Ogawa H (2009)	1
RAD54L2	5	DCAF7	4	affinity chromatography technology, affinity chromatography technology	Tsuchiya M (2015), Huttlin EL (2017)	2
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
PSMA3	1	KHSRP	5	affinity chromatography technology	Fedorova OA (2011)	1
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
SUMO2	0	RAD54L2	5	pull down	Ouyang J (2009)	1
UBE2I	0	NR3C1	2	enzymatic study	Ogawa H (2009)	1
RAD54L2	5	RXRA	1	pull down	Ogawa H (2009)	1
SIAH1	2	UBE2I	0	two hybrid, two hybrid	Depaux A (2007), Hu G (1997)	2
ATN1	2	RBPMS	0	two hybrid	Lim J (2006)	1
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
RAD54L2	5	AR	3	affinity chromatography technology, two hybrid, pull down	Domanskyi A (2006), Domanskyi A (2006), Ogawa H (2009)	3
RAD54L2	5	DYRK1A	36	affinity chromatography technology	Tsuchiya M (2015)	1
UBE2I	0	KHSRP	5	enzymatic study	Yuan H (2017)	1
NR3C1	2	SUMO1	0	affinity chromatography technology	Lin DY (2006)	1
UBE2I	0	NR5A1	1	enzymatic study	Ogawa H (2009)	1
UBE2I	0	PPARG	0	enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology	Ogawa H (2009), Hartig SM (2015), Hartig SM (2015)	3
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
CNOT7	0	RAD54L2	5	affinity chromatography technology, two hybrid	Huttlin EL (2015), Yu H (2011)	2
SUMO1	0	RAD54L2	5	two hybrid	Rolland T (2014)	1
ATXN1	2	SUMO1	0	two hybrid	Kang S (2010)	1
PCDHAC2	1	RAD54L2	5	affinity chromatography technology	Huttlin EL (2017)	1
RAD54L2	5	UBE2I	0	two hybrid	Domanskyi A (2006)	1
EGLN3	0	RAD54L2	5	affinity chromatography technology	Rodriguez J (2016)	1
ATN1	2	PSMA3	1	two hybrid	Lim J (2006)	1
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
ATXN1L	0	RAD54L2	5	two hybrid	Lim J (2006)	1
NR5A1	1	RAD54L2	5	affinity chromatography technology, affinity chromatography technology, pull down	Ogawa H (2009), Ogawa H (2009), Ogawa H (2009)	3
RAD54L2	5	PPARG	0	pull down	Ogawa H (2009)	1
ATN1	2	SIAH1	2	two hybrid, two hybrid	Lim J (2006), Wang J (2011)	2
ATXN1L	0	ATXN1	2	two hybrid, affinity chromatography technology, two hybrid	Mizutani A (2005), Mizutani A (2005), Lim J (2006)	3
ATXN1	2	PIAS1	4	two hybrid	Suter B (2013)	1
RAD54L2	5	NR5A2	4	pull down	Ogawa H (2009)	1
RAD54L2	5	TAX1BP1	3	two hybrid	Yu H (2011)	1
RAD54L2	5	PIAS1	4	pull down	Ogawa H (2009)	1
EGLN3	0	CNOT7	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	DYRK1A	36	affinity chromatography technology	Rodriguez J (2016)	1
PSMA3	1	RAD54L2	5	two hybrid	Rolland T (2014)	1
PPARG	0	PIAS1	4	affinity chromatography technology, imaging technique	Pascual G (2005), Pascual G (2005)	2
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
RBPMS	0	RAD54L2	5	two hybrid	Yu H (2011)	1
SIAH1	2	RAD54L2	5	two hybrid	Rolland T (2014)	1
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1