PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RASSF1	3	LATS1	3	affinity chromatography technology	Guo C (2007)	1
BTRC	1	RASSF1	3	two hybrid, affinity chromatography technology, bioid, affinity chromatography technology	Vinayagam A (2011), Zhou X (2012), Coyaud E (2015), Huttlin EL (2017)	4
CDHR2	2	MAST2	4	two hybrid, affinity chromatography technology, imaging technique	Okazaki N (2002), Okazaki N (2002), Okazaki N (2002)	3
LATS1	3	APP	1	pull down	Olah J (2011)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
MAST2	4	TRAF2	1	affinity chromatography technology	Xiong H (2004)	1
SH3GL2	1	APP	1	pull down	Olah J (2011)	1
MAST2	4	TRAF6	0	affinity chromatography technology	Xiong H (2004)	1
MAST2	4	SUMO2	0	two hybrid	Wang J (2011)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
FBXW11	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
FBXW11	2	MAST2	4	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
TRAF6	0	SMN1	0	affinity chromatography technology	Kim EK (2017)	1
HSP90AA1	7	BTRC	1	affinity chromatography technology	Taipale M (2012)	1
YWHAE	0	MAST2	4	affinity chromatography technology	Gloeckner CJ (2007)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
RASSF1	3	MAST2	4	affinity chromatography technology	Matallanas D (2011)	1
SRPK2	1	MAST2	4	enzymatic study	Lipp JJ (2015)	1
HSP90AA1	7	GAN	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Johnson-Kerner BL (2015)	2
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
SH3GL2	1	MAST2	4	two hybrid	Vinayagam A (2011)	1
EGFR	5	MAST2	4	affinity chromatography technology	Yao Z (2017)	1
FBXW11	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
HSP90AA1	7	FBXW11	2	affinity chromatography technology	Taipale M (2012)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
YWHAB	1	MAST2	4	affinity chromatography technology	Couzens AL (2013)	1
EGFR	5	SH3GL2	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmidt MH (2004), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Liu W (2014), Liu W (2014)	6
LATS1	3	MAST2	4	affinity chromatography technology	Matallanas D (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
TK1	0	MAST2	4	two hybrid	Vinayagam A (2011)	1
GAN	4	MAST2	4	affinity chromatography technology	Johnson-Kerner BL (2015)	1
EGFR	5	GCN1	6	affinity chromatography technology	Foerster S (2013)	1
YWHAB	1	APP	1	pull down	Olah J (2011)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
SMN1	0	MAST2	4	two hybrid	Vinayagam A (2011)	1
BTRC	1	MAST2	4	bioid	Coyaud E (2015)	1
SRPK2	1	APP	1	pull down	Olah J (2011)	1
SNTB2	4	MAST2	4	pull down	Lumeng C (1999)	1
MAST2	4	APP	1	pull down	Olah J (2011)	1
STK36	7	MAST2	4	two hybrid	Nakayama M (2002)	1
MAST2	4	GCN1	6	affinity chromatography technology	Ewing RM (2007)	1
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
BTRC	1	YWHAE	0	affinity chromatography technology	Coyaud E (2015)	1
SRPK2	1	YWHAB	1	enzymatic study, affinity chromatography technology	Varjosalo M (2013), Jang SW (2009)	2
STK36	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Kise Y (2006), Schweiger S (2014)	2
TK1	0	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	MAST2	4	affinity chromatography technology	Taipale M (2012)	1
BTRC	1	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1