PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
TRIM25	5	DCUN1D4	0	affinity chromatography technology	Choudhury NR (2017)	1
DCUN1D4	0	CUL4B	8	pull down, enzymatic study	Monda JK (2013), Monda JK (2013)	2
VAV2	6	DCUN1D4	0	two hybrid	Thalappilly S (2008)	1
DCUN1D4	0	TOP3A	0	biochemical	Wan C (2015)	1
CUL4B	8	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	VAV2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
RBX1	2	CUL4B	8	affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, imaging technique	Dias DC (2002), Ji Q (2014), Huang DT (2009), Hein MY (2015), Yang Y (2015)	5
BUD31	0	DCUN1D4	0	biochemical	Wan C (2015)	1
CUL4A	2	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Angers S (2006), Hu J (2004), Chua YS (2011), Tron AE (2012), Zheng J (2002), He YJ (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Olma MH (2009), Olma MH (2009), Yang Y (2016), Yang Y (2016)	18
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
DCUN1D4	0	CUL1	7	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
TRIM25	5	VAV2	6	affinity chromatography technology	Choudhury NR (2017)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
RNF7	0	CUL3	17	enzymatic study	Huang DT (2009)	1
DCUN1D4	0	CUL2	3	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
CUL2	3	UBE2M	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
DCUN1D4	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	UBE2M	0	pull down, pull down, pull down, pull down, x-ray crystallography, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, enzymatic study, pull down	Okuda H (2001), Yoshida Y (2005), Choi YS (2010), Calabrese MF (2011), Calabrese MF (2011), Kim AY (2008), Scott DC (2014), Markson G (2009), Sufan RI (2006), Huang DT (2009), Morimoto M (2003), Ohki Y (2009), Ohki Y (2009), Wang X (2015)	14
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
DCUN1D4	0	CUL3	17	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	5
UBE2M	0	CUL1	7	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Huang G (2011), Huang G (2011), Kim AY (2008), Ponyeam W (2012), Ohki Y (2009), Zhou W (2017), Mo Z (2016)	7
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
UBE2M	0	CUL5	1	enzymatic study	Duda DM (2008)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
DCUN1D4	0	CUL5	1	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
CAND1	2	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D4	0	MSRB3	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL5	1	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	UBE2M	0	pull down	Kim AY (2008)	1
TRIM25	5	CUL5	1	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	DCUN1D4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DCUN1D4	0	RBX1	2	affinity chromatography technology	Keuss MJ (2016)	1
RNF7	0	UBE2M	0	pull down	Huang DT (2009)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Menon S (2008), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012)	7
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	DCUN1D4	0	pull down, pull down	Monda JK (2013), Keuss MJ (2016)	2
RNF7	0	CUL1	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ohta T (1999), Kawakami T (2001), Tan M (2010), Swaroop M (2001), Huang DT (2009), Kuang P (2016), Zhou W (2017)	7
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
TRIM25	5	CAND1	2	affinity chromatography technology	Choudhury NR (2017)	1
CAND1	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Kim AY (2008), Zheng J (2002), Zheng J (2002), Liu J (2002), Liu J (2002)	7
CUL5	1	RBX1	2	x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Duda DM (2008), Ohta T (1999), Furukawa M (2002), Tron AE (2012), Tron AE (2012), Yu Y (2004), Huang DT (2009), Wang X (2015), Wang X (2015), Wang X (2015)	10
DCUN1D4	0	CUL4A	2	pull down, enzymatic study	Monda JK (2013), Monda JK (2013)	2
RNF7	0	CUL4A	2	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
DCUN1D4	0	ARL4C	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF7	0	CUL4B	8	enzymatic study	Huang DT (2009)	1
RNF7	0	CUL2	3	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
DCUN1D4	0	CAND1	2	affinity chromatography technology, pull down	Keuss MJ (2016), Keuss MJ (2016)	2
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1