PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	CSNK2B	5	affinity chromatography technology	Emdal KB (2015)	1
CSNK2B	5	CIC	9	two hybrid	Vinayagam A (2011)	1
PLK1	0	CIC	9	two hybrid	Vinayagam A (2011)	1
CIC	9	PICK1	2	two hybrid	Lim J (2006)	1
NTRK1	1	EWSR1	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CIC	9	affinity chromatography technology	Emdal KB (2015)	1
EWSR1	2	CIC	9	bioid	Elzi DJ (2014)	1
FOXK2	9	CIC	9	affinity chromatography technology	Li X (2015)	1
CIC	9	PYCR2	1	two hybrid	Lim J (2006)	1
CIC	9	SETD2	20	two hybrid	Lim J (2006)	1
NTRK1	1	PYCR2	1	affinity chromatography technology	Emdal KB (2015)	1
ATXN1	2	SETD2	20	two hybrid	Lim J (2006)	1
CIC	9	SEC62	1	two hybrid	Lim J (2006)	1
CIC	9	GABPB1	0	two hybrid	Lim J (2006)	1
NTRK1	1	PLK1	0	affinity chromatography technology	Emdal KB (2015)	1
CIC	9	CENPJ	6	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
CENPJ	6	PLK1	0	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CIC	9	ZNRD1	0	two hybrid	Lim J (2006)	1
CIC	9	TRIM22	2	two hybrid	Lim J (2006)	1
ZBTB18	9	CIC	9	affinity chromatography technology	Huttlin EL (2017)	1
EYA2	2	CIC	9	bioid	St-Denis N (2016)	1
CIC	9	GTPBP3	4	two hybrid	Lim J (2006)	1
ATXN1	2	CIC	9	two hybrid, two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006), Huttlin EL (2017)	3
NFYC	0	CIC	9	two hybrid	Bandyopadhyay S (2010)	1
FOXK2	9	NFYC	0	affinity chromatography technology	Li X (2015)	1