PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K3	1	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KLC1	5	KLC2	2	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
MAPK8IP3	9	ACTR10	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
ALK	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology	Crockett DK (2004), Crockett DK (2004)	2
NTRK1	1	KLC1	5	affinity chromatography technology	Emdal KB (2015)	1
MAPK8IP3	9	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Matsuura H (2002), Song JJ (2004)	5
MAP3K11	7	MAP2K7	5	enzymatic study, enzymatic study	Merritt SE (1999), Zhang H (2004)	2
MAP2K7	5	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Yasuda J (1999), Yasuda J (1999), Santos CR (2006), Blanco S (2008), Blanco S (2008)	5
NTRK1	1	SPAG9	5	affinity chromatography technology	Emdal KB (2015)	1
MAPK8IP3	9	KLC2	2	affinity chromatography technology, pull down	Bowman AB (2000), Bowman AB (2000)	2
RCCD1	2	MAPK8IP3	9	affinity chromatography technology	Huttlin EL (2017)	1
ALK	8	MAP3K5	1	affinity chromatography technology	Crockett DK (2004)	1
MAPK8IP3	9	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
MAPK8IP3	9	DCTN6	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	MAP2K3	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PTK2	2	affinity chromatography technology	Fei T (2017)	1
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
MAP2K7	5	MAP3K5	1	affinity chromatography technology	Zama T (2002)	1
MAP2K3	1	MAPK8IP3	9	affinity chromatography technology	Hsu CH (2010)	1
NTRK1	1	KLC2	2	affinity chromatography technology	Emdal KB (2015)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
ALK	8	MAP2K7	5	affinity chromatography technology	Crockett DK (2004)	1
SRC	2	MAPK8IP3	9	enzymatic study	Takino T (2002)	1
HNRNPL	3	KIF1A	19	affinity chromatography technology	Fei T (2017)	1
MAP2K3	1	MAP3K5	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	McLaughlin NJ (2006), McLaughlin NJ (2006), Yoon KW (2009), Yoon KW (2009), Ivanov AA (2017)	5
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
NTRK1	1	KIF1A	19	affinity chromatography technology	Emdal KB (2015)	1
MAP3K11	7	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999), Humphrey RK (2013), Humphrey RK (2013)	4
SPAG9	5	MAP2K4	3	affinity chromatography technology	Lee CM (2002)	1
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
HNRNPL	3	MAPK8IP3	9	affinity chromatography technology	Fei T (2017)	1
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
MAP3K5	1	RAF1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Chen J (2001), Chen J (2001), Ivanov AA (2017)	3
MAP2K4	3	MAP3K5	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Ryoo K (2004), Song JJ (2004), Kim EK (2007), Zhang H (2004)	4
MAPK8IP2	5	MAPK10	0	pull down	Negri S (2000)	1
MAPK9	3	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Whitmarsh AJ (1998), Song JJ (2005), Huttlin EL (2017)	5
NTRK1	1	PTK2	2	affinity chromatography technology	Emdal KB (2015)	1
MAPK8IP3	9	KLC1	5	two hybrid, affinity chromatography technology, pull down	Bowman AB (2000), Bowman AB (2000), Bowman AB (2000)	3
NTRK1	1	DCTN4	2	affinity chromatography technology	Emdal KB (2015)	1
MAPK8IP2	5	MAP2K3	1	affinity chromatography technology, affinity chromatography technology	Buchsbaum RJ (2002), Hsu CH (2010)	2
SPAG9	5	MAPK8	3	affinity chromatography technology	Lee CM (2002)	1
RIC8A	4	ACTR10	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK9	3	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
RAF1	3	BCL6	6	enzymatic study	Jin S (2005)	1
RIC8A	4	DCTN6	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP2K4	3	MAP2K7	5	genetic interference, affinity chromatography technology, affinity chromatography technology	Fleming Y (2000), Sundarrajan M (2003), Sundarrajan M (2003)	3
PTK2	2	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Hecker TP (2002), Angers-Loustau A (1999), Relou IA (2003), Messina S (2003), Lebrun P (1998), Ponnala S (2011), Grossmann A (2015), Chen TC (2014), Lee J (2013), Reiske HR (2000)	11
MAP3K1	4	MAP2K7	5	affinity chromatography technology, pull down	Tu Z (2003), Takekawa M (2005)	2
BCL6	6	MAPK8IP3	9	affinity chromatography technology	Miles RR (2005)	1
KIF1A	19	MAPK8IP3	9	biochemical	Wan C (2015)	1
SMCO1	0	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP3	9	MAP3K1	4	affinity chromatography technology	Ito M (1999)	1
MAPK8IP3	9	MAP2K1	8	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
DCTN6	0	ACTR10	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
RCCD1	2	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K11	7	MAP2K4	3	enzymatic study	Merritt SE (1999)	1
MAPK8IP3	9	PTK2	2	affinity chromatography technology, affinity chromatography technology	Takino T (2002), Takino T (2002)	2
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
MAPK8IP3	9	MAP3K11	7	pull down	Kelkar N (2000)	1
MAP2K3	1	SPAG9	5	affinity chromatography technology	Hsu CH (2010)	1
MAPK8IP3	9	MAPK8IP1	7	affinity chromatography technology	Huttlin EL (2017)	1
KAT2A	1	MAPK8IP3	9	affinity chromatography technology	Kim J (2010)	1
RAD51	3	MAPK8IP3	9	two hybrid	Arroyo R (2015)	1
MAPK8IP3	9	MAPK8	3	pull down, pull down, enzymatic study	Ito M (1999), Kelkar N (2000), Kelkar N (2000)	3
MAPK8IP3	9	RIC8A	4	two hybrid	Stelzl U (2005)	1
ACTR10	0	DCTN4	2	biochemical, biochemical, biochemical, genetic interference	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Horlbeck MA (2018)	4
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
MAP2K3	1	MAPK8IP1	7	affinity chromatography technology	Hsu CH (2010)	1
ALK	8	SRC	2	affinity chromatography technology	Ambrogio C (2005)	1
MAP3K11	7	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
MAPK8IP3	9	TNKS2	6	affinity chromatography technology	Huttlin EL (2017)	1
ALK	8	MAPK8IP3	9	affinity chromatography technology	Crockett DK (2004)	1
NTRK1	1	RIC8A	4	affinity chromatography technology	Emdal KB (2015)	1
MAPK8	3	MAP2K7	5	enzymatic study, enzymatic study, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Tournier C (1997), Tournier C (1997), Tournier C (1997), Cheng J (2000), Ho DT (2006), Ho DT (2006), Ho DT (2006), Ho DT (2006), Enomoto A (2003), Takeda AN (2014), Sundarrajan M (2003), Chen TC (2014), Zhu T (2016), Zhu T (2016)	14
MAPK8IP3	9	MAPK10	0	two hybrid, two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Ito M (1999), Ito M (1999), Ito M (1999), Ito M (1999), Kelkar N (2000), Matsuura H (2002), Matsuura H (2002)	7
NTRK1	1	MAPK8IP3	9	affinity chromatography technology	Emdal KB (2015)	1
RIC8A	4	DCTN4	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8	3	RAF1	3	two hybrid	Wang J (2011)	1
MAPK8IP3	9	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
DCTN4	2	DCTN6	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
MAPK8IP1	7	MAPK8	3	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Whitmarsh AJ (1998), Cai Y (2002), Ho DT (2006), Song JJ (2005), Blanco S (2008), Blanco S (2008), Nishitani Y (2006), Huttlin EL (2017)	8
SMCO1	0	MAPK8IP3	9	affinity chromatography technology	Huttlin EL (2017)	1
MAP2K4	3	MAPK10	0	enzymatic study, pull down, unspecified method	Ryoo K (2004), Ho DT (2003), Ho DT (2003)	3
MAPK8IP3	9	TNKS	12	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8	3	MAP2K1	8	unspecified method	Ho DT (2006)	1
MAP2K7	5	MAPK8IP2	5	affinity chromatography technology, pull down, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999), Negri S (2000)	4
SRC	2	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
ARL4D	0	MAPK8IP3	9	two hybrid	Stelzl U (2005)	1
MAP3K1	4	MAPK9	3	two hybrid, pull down	Gallagher ED (2004), Gallagher ED (2002)	2
MAPK8IP1	7	MAPK8IP2	5	affinity chromatography technology, pull down, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Huttlin EL (2017)	3
MAPK8IP3	9	MAPK8IP2	5	pull down, pull down, affinity chromatography technology	Kelkar N (2000), Kelkar N (2000), Huttlin EL (2017)	3
MAPK8IP3	9	DCTN4	2	affinity chromatography technology	Huttlin EL (2017)	1
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
MAP2K1	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karandikar M (2000), Karandikar M (2000), Tu Z (2003)	3
MAPK8IP3	9	WDR54	0	affinity chromatography technology	Huttlin EL (2017)	1
RAF1	3	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1