PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
VEGFA	3	FLT1	4	pull down, affinity chromatography technology	Allain B (2012), Huttlin EL (2017)	2
FLT1	4	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Zhao WD (2010), Zhao WD (2010)	2
FLT1	4	KDR	4	enzymatic study, affinity chromatography technology	Autiero M (2003), Raikwar NS (2014)	2
FLT1	4	PTPN11	20	imaging technique	Chen TC (2014)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
PGF	0	VEGFA	3	biochemical, imaging technique	Eriksson A (2002), Chen TC (2014)	2
FLT1	4	SHC1	0	two hybrid	Warner AJ (2000)	1
VEGFB	2	VEGFA	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017)	3
FLT1	4	VEGFB	2	affinity chromatography technology, pull down, pull down	Olofsson B (1998), Olofsson B (1998), Makinen T (1999)	3
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
VEGFA	3	KDR	4	enzymatic study, pull down, pull down, imaging technique, pull down	Luque A (2003), Di Benedetto M (2008), Tirand L (2006), Koutsioumpa M (2015), Patel NS (2010)	5
SRPK1	2	FLT1	4	enzymatic study	Varjosalo M (2013)	1
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
FLT1	4	PLCG1	6	pull down, two hybrid	Cunningham SA (1997), Cunningham SA (1997)	2
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
CBL	7	KDR	4	pull down, affinity chromatography technology	Singh AJ (2007), Wang Y (2009)	2
KDR	4	PLCG1	6	pull down	Cunningham SA (1997)	1
KDR	4	PTPN11	20	two hybrid, affinity chromatography technology, far western blotting	Yao Z (2017), Mitola S (2006), Mitola S (2006)	3
SCGB2A2	0	FLT1	4	affinity chromatography technology	Huttlin EL (2017)	1
FLT1	4	SHC2	3	two hybrid, two hybrid	Warner AJ (2000), Igarashi K (1998)	2
SHC1	0	SHC2	3	affinity chromatography technology	Huttlin EL (2017)	1
FLT1	4	CBL	7	affinity chromatography technology	Raikwar NS (2014)	1
NEDD4	2	FLT1	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
FLT1	4	PGF	0	pull down	Davis-Smyth T (1998)	1
KDR	4	SHC2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Warner AJ (2000), Warner AJ (2000), Warner AJ (2000), Ratcliffe KE (2002), Ratcliffe KE (2002), Igarashi K (1998)	6
SHC1	0	KDR	4	affinity chromatography technology, affinity chromatography technology	Zanetti A (2002), DAngelo G (1999)	2