PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MGRN1	4	MRAP	1	affinity chromatography technology	Cooray SN (2011)	1
FAM19A4	0	MGRN1	4	affinity chromatography technology	Huttlin EL (2017)	1
MGRN1	4	INTS7	1	affinity chromatography technology	Huttlin EL (2017)	1
TAZ	1	MGRN1	4	affinity chromatography technology	Huttlin EL (2015)	1
UBE2D1	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Wang Y (2014)	3
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
AMFR	2	HSPA4	3	affinity chromatography technology	Jo Y (2011)	1
MGRN1	4	MC4R	1	affinity chromatography technology	Perez-Oliva AB (2009)	1
PTPRK	1	ATRN	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MGRN1	4	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Chhangani D (2013), Chhangani D (2013)	2
FBXO6	0	HNRNPL	3	affinity chromatography technology	Liu B (2012)	1
MGRN1	4	ATRN	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2G2	0	MGRN1	4	two hybrid	van Wijk SJ (2009)	1
UBE2D3	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
ELAVL1	0	ANKRD46	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TAZ	1	MEGF8	9	affinity chromatography technology	Huttlin EL (2015)	1
AMFR	2	ATXN3	2	affinity chromatography technology, imaging technique	Ying Z (2009), Ying Z (2009)	2
PSG8	4	MEGF8	9	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
MGRN1	4	PDCD2	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
UBE2D3	1	MGRN1	4	two hybrid	Markson G (2009)	1
TAZ	1	ANKRD46	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MGRN1	4	MFN1	6	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
ATXN3	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
PTPRK	1	MGRN1	4	affinity chromatography technology	Huttlin EL (2015)	1
TSG101	1	TRIM74	0	two hybrid	Markson G (2009)	1
PTPRK	1	ANKRD46	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	MGRN1	4	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	MGRN1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
AMFR	2	HTT	14	affinity chromatography technology, pull down, pull down	Yang H (2010), Yang H (2010), Yang H (2010)	3
ATXN3	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
UBE2E1	1	NEDD4	2	enzymatic study, pull down, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Anan T (1998), Malakhova OA (2008), Malakhova OA (2008), Woelk T (2006), Sarkari F (2013), Sarkari F (2013), Sugeno N (2014), Zhang X (2017)	8
EGLN3	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
HTT	14	ITCH	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014), Chhangani D (2014)	3
UBE2D2	0	MGRN1	4	two hybrid	Markson G (2009)	1
FBXO6	0	ATRN	4	affinity chromatography technology	Liu B (2012)	1
MC2R	0	MGRN1	4	affinity chromatography technology	Cooray SN (2011)	1
UBE2D1	0	MGRN1	4	two hybrid, pull down	Markson G (2009), Kim BY (2007)	2
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MGRN1	4	ITCH	1	affinity chromatography technology	Gunn TM (2012)	1
BTNL8	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
MGRN1	4	MC1R	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2009), Perez-Oliva AB (2009), Cooray SN (2011)	3
MGRN1	4	TRIM74	0	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Fang S (2001)	3
MGRN1	4	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Gunn TM (2012), Gunn TM (2012)	2
DUSP6	2	MGRN1	4	affinity chromatography technology	Li X (2016)	1
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
PTPRK	1	MEGF8	9	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	PDCD2	0	affinity chromatography technology	Rodriguez J (2016)	1
UBE2T	0	AMFR	2	two hybrid	van Wijk SJ (2009)	1
MGRN1	4	ANKRD46	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	UBE2G2	0	affinity chromatography technology	Rodriguez J (2016)	1
MC2R	0	MRAP	1	affinity chromatography technology	Cooray SN (2011)	1
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
DUSP6	2	UBE2G2	0	affinity chromatography technology	Li X (2016)	1
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
FBXO6	0	MGRN1	4	affinity chromatography technology	Liu B (2012)	1
BTNL8	2	ATRN	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
PSG8	4	MGRN1	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2G2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down	Ewing RM (2007), Cao J (2007), Chen B (2006), Chen B (2006), Chen B (2006), Li W (2009), Li W (2009), Wang Q (2011), Jo Y (2013), Morito D (2008), Das R (2013), Yan L (2014), Liu W (2014), Li W (2009), Liu W (2014), Christianson JC (2012), Liu Y (2014)	17
MGRN1	4	HTT	14	affinity chromatography technology	Chhangani D (2014)	1
UBE2W	0	MGRN1	4	two hybrid	Markson G (2009)	1
EGLN3	0	APBB1	3	affinity chromatography technology	Rodriguez J (2016)	1
MGRN1	4	C9orf40	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	ATRN	4	affinity chromatography technology	Fei T (2017)	1
MGRN1	4	HSDL1	0	affinity chromatography technology	Huttlin EL (2017)	1
ITCH	1	UBE2J2	1	pull down	Sheng Y (2012)	1
ATP1B4	1	MGRN1	4	affinity chromatography technology	Huttlin EL (2015)	1
FBXO6	0	MEGF8	9	affinity chromatography technology	Liu B (2012)	1
UBE2D4	0	MGRN1	4	two hybrid	Markson G (2009)	1
TSG101	1	UBE2I	0	biochemical	Wan C (2015)	1
MGRN1	4	MEGF8	9	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	MGRN1	4	two hybrid	Markson G (2009)	1
ITCH	1	UBE2E1	1	pull down, pull down	Bai Y (2004), Ahn YH (2009)	2
MGRN1	4	TIMM29	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	TSG101	1	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	UBE2J2	1	affinity chromatography technology	Fei T (2017)	1
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
MGRN1	4	APBB1	3	affinity chromatography technology, affinity chromatography technology	Matz A (2014), Matz A (2014)	2
UBE2T	0	MGRN1	4	two hybrid	Markson G (2009)	1
UBE2E1	1	MGRN1	4	two hybrid	Markson G (2009)	1
UBE2J2	1	MGRN1	4	two hybrid	Markson G (2009)	1
EGLN3	0	MGRN1	4	affinity chromatography technology	Rodriguez J (2016)	1
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
EGLN3	0	PTPRK	1	affinity chromatography technology	Rodriguez J (2016)	1
UBE2D4	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
PSG8	4	ANKRD46	0	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	MGRN1	4	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid	Markson G (2009), Kim BY (2007), Kim BY (2007), Kim BY (2007), Kim BY (2007), Kim BY (2007), Kim BY (2007), Jiao J (2009), Jiao J (2009), Rolland T (2014)	10
TUBA4A	1	MGRN1	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Srivastava D (2014), Srivastava D (2014), Srivastava D (2014)	3
NEDD4	2	HNRNPL	3	pull down	Ingham RJ (2005)	1