Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NEDD4L 23327 HYDROCHLOROTHIAZIDE CHEMBL435 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NEDD4L rs4149601 AG + GG Beta blocking agents, selective efficacy yes This was found both for SBP reduction (19.5 ± 16.8 vs. 15.0 ± 19.3 mmHg, P < 0.001) and DBP reduction (15.4 ± 8.3 vs. 14.1 ± 8.4 mm Hg, P = 0.02). Genotypes AG + GG are associated with increased response to Beta blocking agents, selective or diuretics in people with Hypertension as compared to genotype AA. 21052022 1183631485
NEDD4L rs292449 C atenolol efficacy no Allele C is not associated with response to atenolol in people with Hypertension as compared to allele G. 23353631 981747482
NEDD4L rs292449 C hydrochlorothiazide efficacy no Minor allele in the Black patients is opposite to minor allele in Whites. Allele C is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele G. 23353631 981741019
NEDD4L rs1008899 A hydrochlorothiazide efficacy no Allele A is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele G. 23353631 981747509
NEDD4L rs4149601 G Aldosterone antagonists efficacy yes This was true for systolic blood pressure but not for diastolic blood pressure. Allele G is associated with increased response to Aldosterone antagonists or amiloride in people with Hypertension as compared to allele A. 21052022 1183631503
NEDD4L rs75982813 A atenolol efficacy yes Allele A is not associated with response to atenolol in people with Hypertension as compared to allele G. 23353631 981747571
NEDD4L rs1008899 A atenolol efficacy no Allele A is not associated with response to atenolol in people with Hypertension as compared to allele G. 23353631 981747522
NEDD4L rs75982813 AG + GG hydrochlorothiazide efficacy yes If the p for the dominant model (0.0239) is adjusted for 4 SNPs tested, it is 0.092 and the association does not reach significance. Blood pressure reduction for the heterozygote (AG) is less than for either of the homozygotes for both systolic and diastolic blood pressure. Genotypes AG + GG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype AA. 23353631 981747566
NEDD4L rs292449 CC + CG hydrochlorothiazide efficacy yes CC and CG patients had significantly greater reduction in Systolic and in Diastolic Blood pressure than those with GG genotype. A significant association was also seen between the haplotype rs4149601G/rs292449C and greater response to hydrachlorothiazide in Whites. The GC SNP creates ambiguity in knowing which strand is being reported on. The SNP is in a positive chromosomal strand gene, so hopefully the genotypes are being reported in relation to the positive strand. Genotypes CC + CG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG. 23353631 981739388
NEDD4L rs520210 A citalopram efficacy yes GWAS. Responders to antidepressant treatment had a higher frequency of the A allele as compared to non-responders. Responders were patients that showed a 50% or greater reduction, from baseline to final visit, in the self-report 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR). Participants who did not meet this criteria were non-responders. Patients had to complete at least 6 weeks of treatment with citalopram to be included. Allele A is associated with increased response to citalopram in people with Depression as compared to allele G. 23809733 1296598832
NEDD4L rs1008899 AA + AG hydrochlorothiazide efficacy no (trend) Genotypes AA + AG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG. 23353631 981747496
NEDD4L rs4149601 G hydrochlorothiazide efficacy no Allele G is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele A. 23353631 981732098
NEDD4L rs4149601 AG + GG hydrochlorothiazide efficacy yes AG and GG patients had significantly greater reduction in Systolic and in Diastolic Blood pressure than those with AA genotype. As this association was tested as a replication attempt, p was not adjusted for multiple testing as it was for the other SNPs in this study. A significant association was also seen between the haplotype rs4149601G/rs292449C and greater response to hydrachlorothiazide in Whites. Genotypes AG + GG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype AA. 23353631 981728486
NEDD4L rs4149601 G atenolol efficacy no Allele G is not associated with response to atenolol in people with Hypertension as compared to allele A. 23353631 981731560
NEDD4L rs4149601 A diltiazem efficacy no "Response" = change in blood pressure. Allele A is not associated with response to diltiazem in people with Hypertension as compared to allele G. 21052022 1183631490
NEDD4L rs4149601 A hydrochlorothiazide efficacy yes Response was determined by reduction in blood pressure. The systolic blood pressure and diastolic blood pressure reductions in A carriers were greater than those in GG carriers by 6.1 mm Hg (p=0.009) and 2.7 mm Hg (p=0.027), respectively, suggesting that NEDD4L rs4149601 A allele carriers are particularly sensitive to hydrochlorothiazide treatment. No association is found in the patients without hydrochlorothiazide or with hydrochlorothiazide treatment plus another drug. Allele A is associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG. 19635985 1449754439