Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
NEDD4L	23327	HYDROCHLOROTHIAZIDE	CHEMBL435		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
NEDD4L	rs4149601	AG + GG	Beta blocking agents, selective	efficacy	yes	This was found both for SBP reduction (19.5 ± 16.8 vs. 15.0 ± 19.3 mmHg, P < 0.001) and DBP reduction (15.4 ± 8.3 vs. 14.1 ± 8.4 mm Hg, P = 0.02).	Genotypes AG + GG are associated with increased response to Beta blocking agents, selective or diuretics in people with Hypertension as compared to genotype AA.	21052022	1183631485
NEDD4L	rs292449	C	atenolol	efficacy	no		Allele C is not associated with response to atenolol in people with Hypertension as compared to allele G.	23353631	981747482
NEDD4L	rs292449	C	hydrochlorothiazide	efficacy	no	Minor allele in the Black patients is opposite to minor allele in Whites.	Allele C is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele G.	23353631	981741019
NEDD4L	rs1008899	A	hydrochlorothiazide	efficacy	no		Allele A is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele G.	23353631	981747509
NEDD4L	rs4149601	G	Aldosterone antagonists	efficacy	yes	This was true for systolic blood pressure but not for diastolic blood pressure.	Allele G is associated with increased response to Aldosterone antagonists or amiloride in people with Hypertension as compared to allele A.	21052022	1183631503
NEDD4L	rs75982813	A	atenolol	efficacy	yes		Allele A is not associated with response to atenolol in people with Hypertension as compared to allele G.	23353631	981747571
NEDD4L	rs1008899	A	atenolol	efficacy	no		Allele A is not associated with response to atenolol in people with Hypertension as compared to allele G.	23353631	981747522
NEDD4L	rs75982813	AG + GG	hydrochlorothiazide	efficacy	yes	If the p for the dominant model (0.0239) is adjusted for 4 SNPs tested, it is 0.092 and the association does not reach significance. Blood pressure reduction for the heterozygote (AG) is less than for either of the homozygotes for both systolic and diastolic blood pressure.	Genotypes AG + GG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype AA.	23353631	981747566
NEDD4L	rs292449	CC + CG	hydrochlorothiazide	efficacy	yes	CC and CG patients had significantly greater reduction in Systolic and in Diastolic Blood pressure than those with GG genotype. A significant association was also seen between the haplotype rs4149601G/rs292449C and greater response to hydrachlorothiazide in Whites. The GC SNP creates ambiguity in knowing which strand is being reported on. The SNP is in a positive chromosomal strand gene, so hopefully the genotypes are being reported in relation to the positive strand.	Genotypes CC + CG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG.	23353631	981739388
NEDD4L	rs520210	A	citalopram	efficacy	yes	GWAS. Responders to antidepressant treatment had a higher frequency of the A allele as compared to non-responders. Responders were patients that showed a 50% or greater reduction, from baseline to final visit, in the self-report 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR). Participants who did not meet this criteria were non-responders. Patients had to complete at least 6 weeks of treatment with citalopram to be included.	Allele A is associated with increased response to citalopram in people with Depression as compared to allele G.	23809733	1296598832
NEDD4L	rs1008899	AA + AG	hydrochlorothiazide	efficacy	no	(trend)	Genotypes AA + AG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG.	23353631	981747496
NEDD4L	rs4149601	G	hydrochlorothiazide	efficacy	no		Allele G is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele A.	23353631	981732098
NEDD4L	rs4149601	AG + GG	hydrochlorothiazide	efficacy	yes	AG and GG patients had significantly greater reduction in Systolic and in Diastolic Blood pressure than those with AA genotype. As this association was tested as a replication attempt, p was not adjusted for multiple testing as it was for the other SNPs in this study. A significant association was also seen between the haplotype rs4149601G/rs292449C and greater response to hydrachlorothiazide in Whites.	Genotypes AG + GG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype AA.	23353631	981728486
NEDD4L	rs4149601	G	atenolol	efficacy	no		Allele G is not associated with response to atenolol in people with Hypertension as compared to allele A.	23353631	981731560
NEDD4L	rs4149601	A	diltiazem	efficacy	no	"Response" = change in blood pressure.	Allele A is not associated with response to diltiazem in people with Hypertension as compared to allele G.	21052022	1183631490
NEDD4L	rs4149601	A	hydrochlorothiazide	efficacy	yes	Response was determined by reduction in blood pressure. The systolic blood pressure and diastolic blood pressure reductions in A carriers were greater than those in GG carriers by 6.1 mm Hg (p=0.009) and 2.7 mm Hg (p=0.027), respectively, suggesting that NEDD4L rs4149601 A allele carriers are particularly sensitive to hydrochlorothiazide treatment. No association is found in the patients without hydrochlorothiazide or with hydrochlorothiazide treatment plus another drug.	Allele A is associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype GG.	19635985	1449754439