PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PARD6A	0	RHOQ	0	two hybrid	Joberty G (2000)	1
TRIP10	1	WASL	2	pull down, biochemical	Tsujita K (2006), Wan C (2015)	2
RHOQ	0	PARD6B	0	two hybrid, pull down, two hybrid	Neudauer CL (2001), Joberty G (2000), Joberty G (2000)	3
PFN1	0	WASL	2	pull down, pull down, affinity chromatography technology	Mimuro H (2000), Suetsugu S (1998), Suetsugu S (1998)	3
ELAVL1	0	WASL	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	RHOQ	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RHOQ	0	EXOC7	3	two hybrid, affinity chromatography technology	Inoue M (2003), Inoue M (2003)	2
RHOQ	0	TRIP10	1	two hybrid, affinity chromatography technology, pull down	Chang L (2002), Chang L (2002), Chang L (2002)	3
CDC42EP2	0	RHOQ	0	pull down, two hybrid	Joberty G (1999), Joberty G (1999)	2
WASL	2	RHOQ	0	pull down, two hybrid	Abe T (2003), Abe T (2003)	2
CDC42BPG	3	RHOQ	0	pull down	Ng Y (2004)	1
RHOQ	0	GOPC	5	two hybrid, pull down, two hybrid	Neudauer CL (2001), Neudauer CL (2001), Rolland T (2014)	3
PARD6B	0	PARD6A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
ELAVL1	0	PFN1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIP6	2	RHOQ	0	two hybrid	Rolland T (2014)	1
CDC42EP3	1	RHOQ	0	pull down, two hybrid	Joberty G (1999), Joberty G (1999)	2
PFN1	0	RHOQ	0	pull down	Murphy GA (1999)	1