PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
SIRT1	3	NCOR1	9	pull down, affinity chromatography technology	Hisahara S (2008), Hisahara S (2008)	2
CASP3	0	HEY2	0	affinity chromatography technology	Tan M (2006)	1
NCOR1	9	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Farhana L (2007)	2
HEY2	0	SEL1L	2	affinity chromatography technology	Huang CH (2013)	1
HEY2	0	ARL10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HEY2	0	SIN3A	13	affinity chromatography technology	Iso T (2001)	1
DERL2	0	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Lilley BN (2005), Huang CH (2013), Huang CH (2013), Huang CH (2013), Christianson JC (2012)	6
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
HEY2	0	BTRC	1	affinity chromatography technology	Tan M (2006)	1
HDAC1	4	HES1	0	affinity chromatography technology	Shen Q (2005)	1
HEY2	0	HES1	0	pull down	Iso T (2001)	1
ARNT	1	HEY2	0	two hybrid	Chin MT (2000)	1
PLSCR1	0	HEY2	0	two hybrid	Rual JF (2005)	1
HEY1	2	HES1	0	affinity chromatography technology, pull down, pull down	Salat D (2015), Villaronga MA (2010), Lopez-Mateo I (2016)	3
HEY2	0	CARM1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP3	0	BTRC	1	affinity chromatography technology	Tan M (2006)	1
HEY2	0	HEY1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Huang CH (2013), Huang CH (2013), Huttlin EL (2015), Huttlin EL (2017), Villaronga MA (2010), Lopez-Mateo I (2016)	6
HEY2	0	HDAC1	4	pull down	Iso T (2001)	1
ATXN1	2	NCOR1	9	two hybrid	Lim J (2006)	1
HEY2	0	FBXO45	1	affinity chromatography technology	Salat D (2015)	1
HEY1	2	NOTCH1	25	genetic interference	Tang Y (2008)	1
HEY1	2	DERL2	0	affinity chromatography technology	Huang CH (2013)	1
HEY2	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
HEY2	0	SIRT1	3	affinity chromatography technology, pull down	Takata T (2003), Takata T (2003)	2
HEY2	0	NOTCH1	25	genetic interference	Tang Y (2008)	1
HDAC9	7	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhou X (2000), Morrison BE (2006), Sparrow DB (1999), Sparrow DB (1999)	4
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
SIN3A	13	HDAC9	7	affinity chromatography technology, pull down	Koipally J (2002), Petrie K (2003)	2
HDAC9	7	NCOR1	9	pull down, affinity chromatography technology	Petrie K (2003), Petrie K (2003)	2
HTT	14	HEY2	0	two hybrid, affinity chromatography technology	Suter B (2013), Suter B (2013)	2
HTT	14	NCOR1	9	two hybrid	Boutell JM (1999)	1
SYVN1	2	HEY1	2	affinity chromatography technology, affinity chromatography technology	Huang CH (2013), Huang CH (2013)	2
HEY1	2	FBXO45	1	affinity chromatography technology, imaging technique	Salat D (2015), Salat D (2015)	2
ATXN1	2	IST1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	HEY2	0	two hybrid	Rolland T (2014)	1
HEY1	2	SEL1L	2	affinity chromatography technology	Huang CH (2013)	1
HEY2	0	NCOR1	9	affinity chromatography technology, pull down	Iso T (2001), Iso T (2001)	2
IST1	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SEL1L	2	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Wu ZZ (2011), Hosokawa N (2008), Mueller B (2008), Christianson JC (2008), Huang CH (2013), Huang CH (2013), Huang CH (2013), Huang CH (2013), Fujimori T (2013), Iida Y (2011), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), van de Weijer ML (2014), Zhang T (2015), Hosokawa N (2016), Hosokawa N (2016), Hosokawa N (2016), Schulz J (2017), Schulz J (2017)	22
ARNT	1	HEY1	2	two hybrid	Chin MT (2000)	1
SYVN1	2	HEY2	0	affinity chromatography technology, affinity chromatography technology	Huang CH (2013), Huang CH (2013)	2
CASP3	0	ARNT	1	enzymatic study, pull down	Suzuki H (2001), Suzuki H (2001)	2
HES1	0	SIRT1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Takata T (2003), Takata T (2003), Takata T (2003), Takata T (2003)	4
HAND1	0	HEY2	0	pull down	Firulli BA (2000)	1
SYVN1	2	HTT	14	imaging technique, affinity chromatography technology	Yang H (2007), Yang H (2007)	2
HEY2	0	HDAC9	7	affinity chromatography technology	Iso T (2001)	1
HEY2	0	DERL2	0	affinity chromatography technology	Huang CH (2013)	1
ATXN1	2	HEY2	0	two hybrid	Suter B (2013)	1
TRAF1	0	HEY2	0	two hybrid	Rolland T (2014)	1
NOTCH1	25	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
HEY2	0	IST1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DERL2	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Bernardi KM (2010), Huang CH (2013), Huang CH (2013), Huang CH (2013), Zhang T (2015)	6