PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK8IP2	5	CTNNBL1	1	two hybrid	Grossmann A (2015)	1
MAPK9	3	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
MAPK8IP2	5	ZNRD1	0	two hybrid	Grossmann A (2015)	1
VRK2	1	MAP2K7	5	affinity chromatography technology	Blanco S (2008)	1
MAPK8IP2	5	HSPA1A	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAPK8IP2	5	LSM8	0	two hybrid	Grossmann A (2015)	1
MAPK9	3	MAP2K7	5	unspecified method, enzymatic study	Ho DT (2006), Enomoto A (2003)	2
APP	1	SRP19	0	pull down	Virok DP (2011)	1
MAPK8IP2	5	ASRGL1	1	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	RABGAP1L	4	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAPK8IP2	5	CFL1	0	two hybrid	Vinayagam A (2011)	1
MAP3K11	7	MAP2K7	5	enzymatic study, enzymatic study	Merritt SE (1999), Zhang H (2004)	2
MAP2K7	5	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Yasuda J (1999), Yasuda J (1999), Santos CR (2006), Blanco S (2008), Blanco S (2008)	5
MAPK8IP2	5	MAPK8IP2	5	affinity chromatography technology	Yasuda J (1999)	1
MAPK8IP2	5	VCP	6	two hybrid	Vinayagam A (2011)	1
RPS6KB2	3	CFL1	0	affinity chromatography technology	Roy R (2014)	1
ADRB2	0	MAPK8IP2	5	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Kittanakom S (2014)	2
TIAM1	3	MAPK8IP2	5	affinity chromatography technology	Buchsbaum RJ (2002)	1
MAPK8IP1	7	DUSP16	0	affinity chromatography technology, pull down	Willoughby EA (2003), Willoughby EA (2003)	2
PRSS23	1	MAPK8IP2	5	two hybrid	Stelzl U (2005)	1
MAPK8IP2	5	ZNF670	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	ERG28	0	two hybrid	Vinayagam A (2011)	1
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
MAP2K3	1	MAPK8IP3	9	affinity chromatography technology	Hsu CH (2010)	1
MAPK8IP2	5	TP53BP2	5	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	SMS	1	two hybrid	Vinayagam A (2011)	1
FGF12	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FBXW11	2	TIAM1	3	affinity chromatography technology	Kim TY (2014)	1
EZH2	4	HSPA1A	0	affinity chromatography technology	Cao Q (2014)	1
FBXW11	2	MAPK8IP2	5	affinity chromatography technology	Low TY (2014)	1
EZH2	4	VCP	6	affinity chromatography technology	Cao Q (2014)	1
MAPK10	0	UNC119	4	two hybrid	Stelzl U (2005)	1
NUMB	1	APP	1	pull down, imaging technique	Olah J (2011), Chen TC (2014)	2
MAPK8IP2	5	SH2D1B	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	ANGPT1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
EGFR	5	MAPK8IP1	7	unspecified method	Jones RB (2006)	1
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
MAPK8IP2	5	ANAPC10	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	MNDA	0	two hybrid	Grossmann A (2015)	1
MAP3K11	7	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999), Humphrey RK (2013), Humphrey RK (2013)	4
MAPK8IP2	5	ZNF593	1	two hybrid	Vinayagam A (2011)	1
LRP8	4	MAPK8IP2	5	two hybrid	Gotthardt M (2000)	1
SH2D1B	0	HSPA1A	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
APP	1	CFL1	0	two hybrid	Soler-Lopez M (2011)	1
LRP2	13	ANAPC10	0	two hybrid	Gotthardt M (2000)	1
MAP3K10	2	MAPK8IP2	5	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
MAPK8IP2	5	KIFC2	3	two hybrid	Vinayagam A (2011)	1
EGFR	5	HSPA1A	0	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013)	5
MAPK8IP2	5	CRP	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	SPINK2	1	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	ING4	1	two hybrid	Grossmann A (2015)	1
ERBB2	6	MAPK8IP1	7	unspecified method	Jones RB (2006)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
MAPK8IP2	5	CHN1	0	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	MAPK10	0	pull down	Negri S (2000)	1
MAPK9	3	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Whitmarsh AJ (1998), Song JJ (2005), Huttlin EL (2017)	5
MAPK8IP2	5	FGF13	0	affinity chromatography technology, two hybrid	Schoorlemmer J (2002), Grossmann A (2015)	2
C8orf33	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ERBB2	6	DUSP18	0	two hybrid	Yao Z (2017)	1
MAPK8IP2	5	C1QTNF3	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	MSRB3	0	two hybrid	Grossmann A (2015)	1
VCP	6	MAPK13	1	affinity chromatography technology	Yu CC (2013)	1
MAPK8IP2	5	MAP2K3	1	affinity chromatography technology, affinity chromatography technology	Buchsbaum RJ (2002), Hsu CH (2010)	2
MAPK8IP2	5	SMARCB1	1	two hybrid	Vinayagam A (2011)	1
CRP	0	PRSS23	1	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	UNC119	4	two hybrid	Stelzl U (2005)	1
EGFR	5	DUSP18	0	affinity chromatography technology	Yao Z (2017)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
ADRB2	0	HSPA1A	0	affinity chromatography technology	Roy SJ (2013)	1
TP53BP2	5	UNC119	4	two hybrid	Stelzl U (2005)	1
LRP1	25	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
MAP2K3	1	APP	1	pull down	Olah J (2011)	1
MAPK8IP2	5	EZH2	4	two hybrid	Vinayagam A (2011)	1
MAPK13	1	FGF12	4	enzymatic study	Schoorlemmer J (2002)	1
MAPK9	3	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
APP	1	MAPK8IP1	7	two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kajiwara Y (2010), Scheinfeld MH (2003), Scheinfeld MH (2003), Muresan Z (2005), Muresan Z (2005)	5
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
MAPK8IP2	5	ZNF784	0	two hybrid	Vinayagam A (2011)	1
SMARCB1	1	APP	1	pull down	Olah J (2011)	1
LRP1	25	MAPK8IP1	7	two hybrid, pull down, two hybrid	Gotthardt M (2000), Gotthardt M (2000), Kajiwara Y (2010)	3
EGFR	5	MAP2K3	1	affinity chromatography technology	Tong J (2014)	1
IL1B	0	MAPK8IP2	5	genetic interference	Negri S (2000)	1
MAPK8IP2	5	TARBP2	0	two hybrid	Grossmann A (2015)	1
ZNRD1	0	ZNF593	1	two hybrid	Ravasi T (2010)	1
MAP2K3	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
RBX1	2	HSPA1A	0	affinity chromatography technology	Dias DC (2002)	1
EGFR	5	BBS10	2	affinity chromatography technology	Yao Z (2017)	1
MAPK8IP2	5	TMEM128	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	MAPK13	1	affinity chromatography technology, affinity chromatography technology	Schoorlemmer J (2002), Schoorlemmer J (2001)	2
MAPK8IP2	5	AFG3L2	0	two hybrid	Vinayagam A (2011)	1
LRP1	25	ANAPC10	0	two hybrid	Gotthardt M (2000)	1
MAPK8IP2	5	SYNE2	19	two hybrid	Vinayagam A (2011)	1
DUSP16	0	MAPK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), St-Denis N (2016), Li X (2016)	3
MAPK8IP2	5	UBD	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAPK8IP2	5	SPSB3	1	two hybrid	Grossmann A (2015)	1
DUSP16	0	MAPK10	0	affinity chromatography technology	Tanoue T (2001)	1
MAPK8IP2	5	USP46	5	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	GBP2	0	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	NDUFS6	0	two hybrid	Vinayagam A (2011)	1
PRSS23	1	LRP2	13	affinity chromatography technology	Huttlin EL (2015)	1
MAPK8IP3	9	MAP3K11	7	pull down	Kelkar N (2000)	1
MAPK8IP2	5	ITSN1	5	two hybrid	Vinayagam A (2011)	1
MAP3K12	2	MAPK8IP1	7	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
APP	1	FGF13	0	pull down	Virok DP (2011)	1
RPS6KB2	3	HSPA1A	0	affinity chromatography technology	Roy R (2014)	1
EGFR	5	ING4	1	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
MAPK8IP3	9	MAPK8IP1	7	affinity chromatography technology	Huttlin EL (2017)	1
AFG3L2	0	APP	1	pull down	Olah J (2011)	1
MAPK8IP2	5	YY1AP1	0	two hybrid	Vinayagam A (2011)	1
EGFR	5	CFL1	0	protein complementation assay	Deribe YL (2009)	1
MAPK8IP2	5	MASP1	3	two hybrid	Vinayagam A (2011)	1
SCLT1	1	MAPK9	3	bioid	Gupta GD (2015)	1
TULP2	1	MAPK8IP2	5	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
MAPK8IP2	5	NUMB	1	two hybrid	Grossmann A (2015)	1
MAP2K3	1	MAPK8IP1	7	affinity chromatography technology	Hsu CH (2010)	1
TIAM1	3	MAPK8IP1	7	affinity chromatography technology	Buchsbaum RJ (2002)	1
MAP3K11	7	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
MAPK13	1	APP	1	pull down	Olah J (2011)	1
VCP	6	CRMP1	0	two hybrid	Vinayagam A (2011)	1
RAPGEF5	1	MAPK8IP2	5	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP2	5	C8orf33	3	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	RAI1	16	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	MRE11	3	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	FSCN1	2	two hybrid	Vinayagam A (2011)	1
EGFR	5	LRP8	4	affinity chromatography technology	Yao Z (2017)	1
MAPK8IP2	5	CRMP1	0	two hybrid	Vinayagam A (2011)	1
VPS33B	2	APP	1	pull down	Olah J (2011)	1
MAPK8IP2	5	HLA-C	1	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	VRK2	1	pull down	Blanco S (2008)	1
VCP	6	HSPA1A	0	affinity chromatography technology	Yu CC (2013)	1
MAPK8IP2	5	C22orf39	2	two hybrid	Grossmann A (2015)	1
TARBP2	0	APP	1	pull down	Olah J (2011)	1
MAPK8IP3	9	MAPK10	0	two hybrid, two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Ito M (1999), Ito M (1999), Ito M (1999), Ito M (1999), Kelkar N (2000), Matsuura H (2002), Matsuura H (2002)	7
MAPK8IP2	5	SLC39A13	1	two hybrid	Grossmann A (2015)	1
EGFR	5	LRP1	25	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Yao Z (2017)	3
MAP3K12	2	MAP2K7	5	enzymatic study, affinity chromatography technology	Merritt SE (1999), Merritt SE (1999)	2
MAPK8IP2	5	BBS10	2	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	RBX1	2	two hybrid	Vinayagam A (2011)	1
LRP2	13	MAPK8IP2	5	two hybrid, pull down, two hybrid	Gotthardt M (2000), Gotthardt M (2000), Petersen HH (2003)	3
ADRB2	0	HLA-C	1	affinity chromatography technology	Roy SJ (2013)	1
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
FBXW11	2	MRE11	3	affinity chromatography technology	Low TY (2014)	1
LRP8	4	ANAPC10	0	two hybrid	Gotthardt M (2000)	1
MAPK8IP2	5	SRP19	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	DUSP18	0	two hybrid	Grossmann A (2015)	1
EGFR	5	MAP3K12	2	protein complementation assay, affinity chromatography technology	Deribe YL (2009), Deribe YL (2009)	2
MAPK8IP1	7	VRK2	1	affinity chromatography technology, affinity chromatography technology	Blanco S (2008), Blanco S (2008)	2
MAPK8IP2	5	FGF12	4	affinity chromatography technology, two hybrid	Schoorlemmer J (2001), Grossmann A (2015)	2
MAPK8IP2	5	IGIP	0	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	SLPI	0	two hybrid	Grossmann A (2015)	1
SH2D1B	0	APP	1	pull down	Olah J (2011)	1
EGFR	5	MAPK9	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
MAP3K10	2	MAPK8IP1	7	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
MAPK8IP2	5	MAGED4B	0	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	VPS33B	2	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	UNC119	4	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	RPS6KB2	3	two hybrid	Vinayagam A (2011)	1
ADRB2	0	VCP	6	affinity chromatography technology	Roy SJ (2013)	1
MAP2K7	5	MAPK8IP2	5	affinity chromatography technology, pull down, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999), Negri S (2000)	4
RBX1	2	VRK2	1	pull down	Kim S (2014)	1
LRP2	13	MAPK8IP1	7	two hybrid, pull down, two hybrid	Gotthardt M (2000), Gotthardt M (2000), Petersen HH (2003)	3
EZH2	4	RBX1	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	MAPK8IP2	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
MAPK10	0	APP	1	pull down	Olah J (2011)	1
LRP1	25	MAPK8IP2	5	two hybrid, pull down	Gotthardt M (2000), Gotthardt M (2000)	2
PRSS23	1	APP	1	pull down	Olah J (2011)	1
LRP8	4	MAPK8IP1	7	two hybrid	Gotthardt M (2000)	1
ERBB2	6	CHN1	0	unspecified method	Jones RB (2006)	1
MAPK8IP2	5	DUSP16	0	affinity chromatography technology	Willoughby EA (2003)	1
MAPK8IP2	5	SCLT1	1	two hybrid	Grossmann A (2015)	1
MAPK8IP2	5	RBM4	1	two hybrid	Grossmann A (2015)	1
APP	1	MAP3K11	7	pull down	Scheinfeld MH (2003)	1
MAPK8IP2	5	LEFTY2	1	two hybrid	Grossmann A (2015)	1
MAPK8IP1	7	MAPK8IP2	5	affinity chromatography technology, pull down, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Huttlin EL (2017)	3
MAPK8IP3	9	MAPK8IP2	5	pull down, pull down, affinity chromatography technology	Kelkar N (2000), Kelkar N (2000), Huttlin EL (2017)	3
MAPK8IP2	5	23429	0	two hybrid	Grossmann A (2015)	1
SCLT1	1	TP53BP2	5	bioid	Gupta GD (2015)	1
MAPK8IP2	5	PLXNA3	5	two hybrid	Vinayagam A (2011)	1
VCP	6	CTNNBL1	1	affinity chromatography technology	Yu CC (2013)	1
MAPK8IP2	5	GALNT3	5	two hybrid	Grossmann A (2015)	1
EGFR	5	AFG3L2	0	affinity chromatography technology	Tong J (2014)	1
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1
IL1B	0	APP	1	pull down	Olah J (2011)	1
MAPK8IP3	9	MAP2K7	5	pull down, affinity chromatography technology	Kelkar N (2000), Matsuura H (2002)	2
SH2D1B	0	ERBB2	6	unspecified method	Jones RB (2006)	1
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
FBXW11	2	EZH2	4	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
MAP3K12	2	MAPK8IP2	5	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
ERBB2	6	MAPK8IP2	5	unspecified method	Jones RB (2006)	1
LRP1	25	MAP2K7	5	affinity chromatography technology	Huttlin EL (2017)	1