PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
PIN1	0	FKBP1B	0	biochemical	Wan C (2015)	1
HCFC1	4	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003), Mazars R (2010), Daou S (2011), Capotosti F (2011), Capotosti F (2011), Capotosti F (2011), Havugimana PC (2012), Hauri S (2016)	9
FN1	17	DDAH2	1	affinity chromatography technology	Humphries JD (2009)	1
RPS6KA1	3	DDAH2	1	two hybrid	Vinayagam A (2011)	1
FN1	17	RPS6KA5	2	two hybrid	Wang J (2011)	1
DDAH2	1	EPB41L3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIN1	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
DDAH2	1	VAC14	5	two hybrid	Rolland T (2014)	1
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
RAP1B	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
EPB41L2	2	EPB41L1	4	affinity chromatography technology	Huttlin EL (2017)	1
FN1	17	RAP1B	0	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	PPA1	1	affinity chromatography technology	Humphries JD (2009)	1
DNAJB11	3	DDAH2	1	two hybrid	Vinayagam A (2011)	1
RPS6KA5	2	MAP3K20	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TK1	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
DDAH2	1	DDAH1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GADD45G	0	CDKN1A	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Azam N (2001), Azam N (2001), Azam N (2001), Nakayama K (1999)	4
RPS6KA5	2	DDAH2	1	two hybrid	Vinayagam A (2011)	1
STK3	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
CDK4	2	DDAH2	1	two hybrid	Vinayagam A (2011)	1
TRIP13	0	DDAH2	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
EPB41L3	5	EPB41L1	4	affinity chromatography technology	Hauri S (2013)	1
DDAH2	1	CLNS1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MKNK1	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
FN1	17	TK1	0	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	RCC1	2	affinity chromatography technology	Humphries JD (2009)	1
SOX2	4	CDC73	1	affinity chromatography technology	Cox JL (2013)	1
FKBP1B	0	DDAH2	1	biochemical	Wan C (2015)	1
TAF1D	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
DDAH2	1	OGT	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCAM1	2	RAP1B	0	affinity chromatography technology	Humphries JD (2009)	1
DDAH2	1	EPB41L2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC25A35	0	DDAH2	1	affinity chromatography technology	Huttlin EL (2017)	1
DDAH2	1	EPB41L1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANXA7	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
EPB41L3	5	CLNS1A	2	affinity chromatography technology	Hauri S (2013)	1
TNFSF11	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
PPA1	1	DDAH2	1	biochemical	Wan C (2015)	1
ATP1B1	2	DDAH2	1	two hybrid	Vinayagam A (2011)	1
EPB41L3	5	EPB41L2	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
CLNS1A	2	PPA1	1	biochemical	Havugimana PC (2012)	1
FN1	17	CLNS1A	2	affinity chromatography technology	Humphries JD (2009)	1
SMN1	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
VCAM1	2	RCC1	2	affinity chromatography technology	Humphries JD (2009)	1
RCC1	2	DDAH2	1	two hybrid	Vinayagam A (2011)	1
VCAM1	2	DDAH2	1	affinity chromatography technology	Humphries JD (2009)	1
DDAH2	1	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAP3K20	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
TK1	0	CDK4	2	two hybrid	Vinayagam A (2011)	1
GADD45G	0	DDAH2	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	CDK4	2	two hybrid	Vinayagam A (2011)	1
CDC73	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	DDAH2	1	two hybrid	Vinayagam A (2011)	1
CDC73	1	PPA1	1	affinity chromatography technology	Herr P (2015)	1
EPB41L2	2	CLNS1A	2	affinity chromatography technology	Huttlin EL (2017)	1
SOX2	4	DDAH2	1	affinity chromatography technology	Huttlin EL (2017)	1