PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PADI3	2	PADI4	1	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	PADI4	1	enzymatic study	Andrews PS (2010)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
PADI4	1	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Denis H (2009), Denis H (2009), Denis H (2009), Denis H (2009)	4
ELK1	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PADI4	1	ING4	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guo Q (2011), Guo Q (2011), Guo Q (2011)	3
NPM1	0	HDAC2	1	affinity chromatography technology	Liu H (2007)	1
FBXO25	1	NPM1	0	affinity chromatography technology	Teixeira FR (2010)	1
PADI4	1	HIST2H3A	0	enzymatic study	Cuthbert GL (2004)	1
ANXA4	0	PADI4	1	two hybrid	Rolland T (2014)	1
FBXO25	1	PADI4	1	enzymatic study	Teixeira FR (2013)	1
ELK1	2	HDAC1	4	pull down	Yang SH (2001)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
PADI4	1	ELK1	2	affinity chromatography technology, affinity chromatography technology	Zhang X (2011), Zhang X (2011)	2
NPM1	0	APP	1	pull down	Olah J (2011)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
PADI4	1	TP53	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li P (2008), Li P (2008), Li P (2008), Li P (2008), Li P (2008), Li P (2010)	6
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
PADI4	1	APP	1	pull down	Olah J (2011)	1
PADI4	1	HDAC2	1	affinity chromatography technology, pull down, pull down	Li P (2010), Li P (2010), Li P (2010)	3
FBXO25	1	ELK1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Teixeira FR (2013), Teixeira FR (2013), Teixeira FR (2013)	3
ING4	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Shiseki M (2003), Shiseki M (2003), Tsai KW (2008), Iizuka M (2008), Zhang X (2005), Zhang X (2005), Palacios A (2010), Guo Q (2011), Guo Y (2013), Guo Y (2013), Saha A (2011)	11
NPM1	0	HDAC1	4	affinity chromatography technology	Liu H (2007)	1
NPM1	0	PADI4	1	affinity chromatography technology, pull down, enzymatic study	Tanikawa C (2009), Tanikawa C (2009), Tanikawa C (2009)	3