PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
TRIM25	5	RAI14	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MAVS	1	affinity chromatography technology	Liu B (2017)	1
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
DDX58	3	USP3	1	affinity chromatography technology, enzymatic study	Cui J (2014), Cui J (2014)	2
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
PRKCG	3	DDX58	3	enzymatic study	Maharaj NP (2011)	1
PRKCA	7	MBP	0	enzymatic study	Rininsland F (2005)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
RNF122	0	UBE2D3	1	pull down	Peng Z (2010)	1
UBE2D3	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
IKBKE	2	IRF3	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Friedman CS (2008), Nakhaei P (2012), Bharaj P (2016), Zhang Q (2017)	4
UBD	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Nguyen NT (2016), Nguyen NT (2016)	2
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
CYLD	2	USP15	4	affinity chromatography technology	Elliott PR (2016)	1
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
DDX58	3	CYLD	2	affinity chromatography technology	Friedman CS (2008)	1
HDAC6	0	PTPN11	20	affinity chromatography technology	M L (2016)	1
UBC	7	USP3	1	affinity chromatography technology, enzymatic study, pull down, pull down	Nicassio F (2007), Sloper-Mould KE (1999), Zhang X (2017), Kwasna D (2018)	4
UBE2D3	1	ISG15	0	affinity chromatography technology	Arimoto K (2008)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
FBXW7	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, pull down	Song Y (2017), Song Y (2017), Song Y (2017)	3
UBD	0	HDAC6	0	pull down, unspecified method, affinity chromatography technology, imaging technique	Kalveram B (2008), Hard RL (2010), Theng SS (2014), Theng SS (2014)	4
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
DDX58	3	IRF3	4	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Xu LG (2005)	2
PPP6C	7	WRNIP1	3	affinity chromatography technology	Tan P (2017)	1
VAPA	1	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
DDX58	3	PTPN11	20	affinity chromatography technology	Song Y (2017)	1
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
DDX58	3	DDX58	3	pull down	Feng M (2012)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
DDX58	3	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
MAVS	1	IFIT3	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2011), Liu XY (2011)	2
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
TRIM14	1	PPP6C	7	two hybrid, affinity chromatography technology, bioid	Tan P (2017), Tan P (2017), Tan P (2017)	3
TBK1	1	IFIT3	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2011), Liu XY (2011)	2
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
RNF31	3	HDAC6	0	enzymatic study	Kliza K (2017)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
FBXW7	2	DDX58	3	affinity chromatography technology, affinity chromatography technology	Song Y (2017), Song Y (2017)	2
TRIM32	2	DDX58	3	affinity chromatography technology	Zhang J (2012)	1
MBP	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Feng M (2012), Feng M (2012)	2
TBK1	1	PPP6C	7	affinity chromatography technology	Bouwmeester T (2004)	1
USP21	2	DDX58	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Fan Y (2014), Fan Y (2014), Fan Y (2014)	3
IKBKG	0	TRIM14	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014)	3
DDX58	3	TSPAN6	0	affinity chromatography technology	Wang Y (2012)	1
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
DDX58	3	IKBKE	2	affinity chromatography technology	Oshiumi H (2013)	1
UBE2D3	1	DDX58	3	enzymatic study	Arimoto K (2008)	1
DDX58	3	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
PRKCA	7	CBL	7	enzymatic study, affinity chromatography technology, two hybrid	Liu Y (1999), Liu Y (1999), Grossmann A (2015)	3
IKBKE	2	MBP	0	enzymatic study	Ikeda F (2007)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
PTPN11	20	TRIM32	2	two hybrid, two hybrid	Rolland T (2014), Daakour S (2016)	2
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
RNF31	3	PRKCA	7	enzymatic study	Queisser MA (2014)	1
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
MAVS	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
USP4	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Wang L (2013), Wang L (2013)	2
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
HDAC6	0	ISG15	0	affinity chromatography technology, pull down	Nakashima H (2014), Nakashima H (2014)	2
RNF135	1	UBE2D2	0	pull down	Gao D (2009)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
HDAC6	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Choi SJ (2016), Choi SJ (2016)	2
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
CBL	7	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006)	14
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
VAPA	1	DDX58	3	affinity chromatography technology	Hein MY (2015)	1
RNF122	0	UBE2D1	0	pull down	Peng Z (2010)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
DDX58	3	TIA1	0	biochemical	Wan C (2015)	1
TRIM25	5	IRF3	4	affinity chromatography technology	Choudhury NR (2017)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
IRF3	4	CBL	7	affinity chromatography technology, affinity chromatography technology	Zhao X (2016), Zhao X (2016)	2
FBXW7	2	CYLD	2	genetic interference	Bailey ML (2015)	1
PRKCA	7	HDAC6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhu J (2011), Zhu J (2011), Mertz JA (2011), Mertz JA (2011), Mertz JA (2011)	5
USP21	2	CBL	7	two hybrid	Hayes SD (2012)	1
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
PRKCB	4	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
ISG15	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Zou W (2007), Zou W (2007)	2
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
DDX58	3	RAI14	4	affinity chromatography technology	Li S (2011)	1
SRC	2	PTPN11	20	enzymatic study	Vogel W (1996)	1
USP21	2	ISG15	0	enzymatic study	Ye Y (2011)	1
PRKCB	4	RBCK1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tatematsu K (2008), Vallentin A (2007), Vallentin A (2007), Nakamura M (2006), Gustafsson Sheppard N (2012)	5
UBE2K	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TRIM25	5	DDX58	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gack MU (2007), Gack MU (2007), Gack MU (2007), Gack MU (2010), Nistal-Villan E (2010), Nistal-Villan E (2010), Inn KS (2011), Inn KS (2011), Maharaj NP (2011), Oshiumi H (2013), Weng L (2014), Xia ZP (2009), Feng M (2012), Gao D (2009), Gao D (2009), Jiang J (2016), Hu Y (2017), Hu Y (2017)	18
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
RNF122	0	UBE2D2	0	pull down	Peng Z (2010)	1
DDX58	3	CBL	7	affinity chromatography technology	Song Y (2017)	1
PRKCA	7	RBCK1	0	affinity chromatography technology, enzymatic study	Queisser MA (2014), Queisser MA (2014)	2
UBE2D2	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TBK1	1	TRIM14	1	affinity chromatography technology	Zhou Z (2014)	1
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
THAP12	0	DDX58	3	pull down	Now H (2011)	1
IRF3	4	WRNIP1	3	affinity chromatography technology	Li X (2015)	1
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
TBK1	1	SRC	2	affinity chromatography technology	Johnsen IB (2009)	1
DDX58	3	IRGM	1	affinity chromatography technology	Chauhan S (2015)	1
SRC	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Funakoshi-Tago M (2005), Funakoshi-Tago M (2005), Lee SH (2012)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
DDX58	3	RNF122	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2016), Wang W (2016), Wang W (2016), Wang W (2016)	4
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
USP21	2	USP4	3	enzymatic study	Loch CM (2012)	1
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
DDX58	3	USP15	4	affinity chromatography technology, pull down	Zhang H (2015), Zhang H (2015)	2
DDX58	3	TBK1	1	affinity chromatography technology	Oshiumi H (2013)	1
MAVS	1	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
PRKCB	4	RNF31	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Nakamura M (2006)	3
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM25	5	NOP53	2	affinity chromatography technology	Choudhury NR (2017)	1
CBL	7	UBE2D3	1	pull down, pull down	Tsukahara F (2010), Sigismund S (2013)	2
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
DDX58	3	RNF135	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid	Oshiumi H (2013), Gao D (2009), Gao D (2009), Gao D (2009), Gao D (2009), Oshiumi H (2009), Oshiumi H (2009), Oshiumi H (2009), Oshiumi H (2009)	9
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
UBE2K	0	RBCK1	0	two hybrid	Markson G (2009)	1
TRIM14	1	WRNIP1	3	two hybrid, affinity chromatography technology	Tan P (2017), Tan P (2017)	2
MAVS	1	TSPAN6	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Wang Y (2012)	2
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
TBK1	1	MBP	0	enzymatic study	Ikeda F (2007)	1
NOP53	2	USP15	4	affinity chromatography technology	Wang P (2016)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TRIM14	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014), Tan P (2017), Tan P (2017)	5
UBE2D1	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
ISG15	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Zhao C (2005)	2
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
NOP53	2	DDX58	3	affinity chromatography technology	Wang P (2016)	1
DDX58	3	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
UBE2D1	0	HDAC6	0	enzymatic study	Hoeller D (2007)	1
RNF31	3	WRNIP1	3	affinity chromatography technology	Schaeffer V (2014)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
DDX58	3	MEX3C	0	affinity chromatography technology	Kuniyoshi K (2014)	1
MAVS	1	WRNIP1	3	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
CBL	7	UBE2D1	0	pull down, pull down, pull down	Umebayashi K (2008), Sehat B (2008), Tsukahara F (2010)	3
NLRC5	8	DDX58	3	affinity chromatography technology	Cui J (2010)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
ISG15	0	IFIT3	1	affinity chromatography technology	Zhao C (2005)	1
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
IKBKE	2	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
DDX58	3	TRIM14	1	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
PRKCB	4	MBP	0	enzymatic study	Sato T (2014)	1