PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KRTAP10-8	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
RPS6KA1	3	CARHSP1	1	pull down	Auld GC (2005)	1
DAZAP1	1	PIN1	0	biochemical	Wan C (2015)	1
PNMA1	0	FBF1	2	two hybrid	Rolland T (2014)	1
G3BP1	4	DAZAP1	1	affinity chromatography technology	Jain S (2016)	1
DAZAP1	1	CARHSP1	1	biochemical	Wan C (2015)	1
MCM2	3	CARHSP1	1	affinity chromatography technology	Drissi R (2015)	1
PIN1	0	PNMA1	0	two hybrid	Rolland T (2014)	1
CARHSP1	1	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
PIN1	0	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
SRPK2	1	PCBP1	2	affinity chromatography technology, enzymatic study	Varjosalo M (2013), Lipp JJ (2015)	2
CARHSP1	1	DOCK8	10	two hybrid	Rolland T (2014)	1
DAZAP1	1	PCBP1	2	biochemical	Wan C (2015)	1
SGK1	4	PIN1	0	affinity chromatography technology, affinity chromatography technology, pull down	Jo A (2015), Jo A (2015), Jo A (2015)	3
TRAF1	0	CARHSP1	1	two hybrid	Rolland T (2014)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
CARHSP1	1	STC2	0	two hybrid	Stelzl U (2005)	1
FBF1	2	CARHSP1	1	bioid	Gupta GD (2015)	1
PIN1	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
TSC22D1	1	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
HSPB1	2	CARHSP1	1	biochemical	Wan C (2015)	1
TRAF1	0	FBF1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CARHSP1	1	PCBP1	2	biochemical	Wan C (2015)	1
AKT1	1	HSPB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Wu R (2007), Rane MJ (2003), Rane MJ (2003), Rane MJ (2003)	9
FKBP7	2	CARHSP1	1	biochemical	Wan C (2015)	1
CARHSP1	1	IMPA2	0	biochemical	Wan C (2015)	1
HSPB1	2	SMN1	0	affinity chromatography technology	MacIntyre DA (2008)	1
PIN1	0	G3BP1	4	pull down	Ingham RJ (2005)	1
CARHSP1	1	HSPA1A	0	biochemical	Havugimana PC (2012)	1
CARHSP1	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
AKT1	1	SRPK2	1	enzymatic study, affinity chromatography technology, pull down, imaging technique	Jang SW (2009), Jang SW (2009), Jang SW (2009), Jang SW (2009)	4
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
SRPK2	1	CARHSP1	1	enzymatic study	Lipp JJ (2015)	1
PNMA1	0	CARHSP1	1	two hybrid	Rolland T (2014)	1
MCM2	3	HSPA1A	0	affinity chromatography technology	Drissi R (2015)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
PIAS3	2	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
MCM2	3	HSPB1	2	affinity chromatography technology	Drissi R (2015)	1
CARHSP1	1	FKBP2	0	biochemical	Wan C (2015)	1
CARHSP1	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
MCM2	3	PCBP1	2	affinity chromatography technology	Drissi R (2015)	1
SMN1	0	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
SGK1	4	CARHSP1	1	pull down	Auld GC (2005)	1
PIN1	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
G3BP1	4	CARHSP1	1	affinity chromatography technology	Jain S (2016)	1
TK1	0	CARHSP1	1	two hybrid	Vinayagam A (2011)	1
NECAP1	0	CARHSP1	1	biochemical	Wan C (2015)	1
KRTAP10-7	0	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRTAP10-8	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
AKT1	1	CARHSP1	1	pull down	Auld GC (2005)	1
PIN1	0	TRAF1	0	two hybrid	Rolland T (2014)	1
CARHSP1	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1