PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
ORC5 0 CDC6 0 pull down Ramachandran N (2004) 1
XRCC6 3 ORC2 0 affinity chromatography technology, affinity chromatography technology Sibani S (2005), Sibani S (2005) 2
MCM7 5 ORC6 0 pull down Ramachandran N (2004) 1
SNW1 0 ORC6 0 affinity chromatography technology Lleres D (2010) 1
MCM4 3 ORC5 0 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
CDC45 1 ORC2 0 two hybrid Kneissl M (2003) 1
CDC5L 2 ORC1 3 pull down Ramachandran N (2004) 1
ILF2 3 MCM7 5 affinity chromatography technology Karmakar S (2010) 1
FOXE1 2 ORC3 3 affinity chromatography technology Li X (2015) 1
FBXO7 1 ORC3 3 enzymatic study Teixeira FR (2016) 1
ORC3 3 ORC6 0 two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004) 6
NTRK1 1 KLC1 5 affinity chromatography technology Emdal KB (2015) 1
FOXE1 2 ORC2 0 affinity chromatography technology Li X (2015) 1
ORC6 0 LRWD1 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
KLC1 5 APP 1 pull down, affinity chromatography technology Kamal A (2000), Muresan Z (2005) 2
TERF2 2 MCM7 5 affinity chromatography technology Giannone RJ (2010) 1
SNW1 0 XRCC6 3 affinity chromatography technology Lleres D (2010) 1
ZBP1 2 ORC3 3 affinity chromatography technology Li S (2011) 1
CDC5L 2 PLK1 0 affinity chromatography technology Lleres D (2010) 1
ORC4 1 APP 1 pull down Olah J (2011) 1
STN1 0 APP 1 pull down Olah J (2011) 1
MCM4 3 MCM7 5 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016) 9
ORC6 0 ORC2 0 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017) 8
CDC5L 2 ORC3 3 affinity chromatography technology Lleres D (2010) 1
ORC3 3 ORC1 3 pull down, affinity chromatography technology Ramachandran N (2004), Hein MY (2015) 2
FOXQ1 0 LRWD1 1 affinity chromatography technology Li X (2015) 1
SNW1 0 CDC5L 2 affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010) 4
ORC4 1 MCM10 2 pull down Ramachandran N (2004) 1
ILF2 3 XRCC5 5 affinity chromatography technology Shi L (2007) 1
TERF2 2 ORC3 3 pull down Tatsumi Y (2008) 1
ILF2 3 ORC2 0 affinity chromatography technology Karmakar S (2010) 1
MCM10 2 APP 1 pull down, affinity chromatography technology Olah J (2011), Huttlin EL (2017) 2
SNW1 0 LRWD1 1 affinity chromatography technology Lleres D (2010) 1
PLK1 0 ORC3 3 affinity chromatography technology Hein MY (2015) 1
CDC45 1 ORC6 0 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
ORC4 1 ORC5 0 two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004) 5
TERF2 2 ORC1 3 pull down, affinity chromatography technology Tatsumi Y (2008), Tatsumi Y (2008) 2
MCM4 3 PLK1 0 affinity chromatography technology Boldt K (2016) 1
MCM4 3 ORC2 0 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
QSOX2 3 ORC3 3 affinity chromatography technology Hein MY (2015) 1
NTRK1 1 MCM4 3 affinity chromatography technology Emdal KB (2015) 1
CDC45 1 ORC5 0 pull down Ramachandran N (2004) 1
CDC5L 2 ORC4 1 affinity chromatography technology Lleres D (2010) 1
SNW1 0 ORC5 0 affinity chromatography technology Lleres D (2010) 1
NTRK1 1 KIFAP3 1 affinity chromatography technology Emdal KB (2015) 1
FOXQ1 0 ORC2 0 affinity chromatography technology Li X (2015) 1
XRCC6 3 TERF2 2 two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology Song K (2000), Song K (2000), Song K (2000), Lee OH (2011), Hein MY (2015) 5
FOXL1 0 NOP9 1 affinity chromatography technology Li X (2015) 1
SNW1 0 ORC4 1 affinity chromatography technology Lleres D (2010) 1
NTRK1 1 CDC5L 2 affinity chromatography technology Emdal KB (2015) 1
LRWD1 1 ORC5 0 biochemical, affinity chromatography technology Havugimana PC (2012), Hein MY (2015) 2
MCM7 5 ORC1 3 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
MCM7 5 ORC4 1 pull down Ramachandran N (2004) 1
ILF2 3 XRCC6 3 affinity chromatography technology Shi L (2007) 1
ORC4 1 XRCC6 3 affinity chromatography technology Sibani S (2005) 1
NTRK1 1 CDC45 1 affinity chromatography technology Emdal KB (2015) 1
BRCA1 7 TERF2 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Ballal RD (2009), Ballal RD (2009), Hill SJ (2014) 3
VAPA 1 ORC3 3 affinity chromatography technology Hein MY (2015) 1
ORC1 3 ORC2 0 two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015) 11
HIST4H4 1 LRWD1 1 unspecified method Vermeulen M (2010) 1
SNW1 0 ORC3 3 affinity chromatography technology Lleres D (2010) 1
XRCC5 5 ORC3 3 affinity chromatography technology, affinity chromatography technology, imaging technique Sibani S (2005), Sibani S (2005), Sibani S (2005) 3
MCM4 3 CDC45 1 affinity chromatography technology Tan BC (2006) 1
ORC2 0 ORC4 1 two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010) 11
TEAD2 2 ORC2 0 affinity chromatography technology Li X (2015) 1
RPGR 0 ORC2 0 affinity chromatography technology Huttlin EL (2017) 1
SNW1 0 PLK1 0 affinity chromatography technology Lleres D (2010) 1
MCM4 3 ORC6 0 two hybrid, two hybrid, pull down Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004) 3
TEAD2 2 ORC4 1 affinity chromatography technology Li X (2015) 1
PLK1 0 BRCA1 7 affinity chromatography technology, affinity chromatography technology Zou J (2013), Zou J (2014) 2
NTRK1 1 SNW1 0 affinity chromatography technology Emdal KB (2015) 1
ORC5 0 ORC6 0 two hybrid Kneissl M (2003) 1
BRCA1 7 ILF2 3 affinity chromatography technology Ertych N (2016) 1
XRCC6 3 ORC6 0 affinity chromatography technology, affinity chromatography technology Sibani S (2005), Sibani S (2005) 2
CDC5L 2 MCM10 2 pull down Ramachandran N (2004) 1
CDC6 0 ORC3 3 pull down Ramachandran N (2004) 1
TERF2 2 ORC6 0 pull down Tatsumi Y (2008) 1
XRCC5 5 XRCC6 3 two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017) 46
CDC5L 2 ORC2 0 pull down, affinity chromatography technology Ramachandran N (2004), Lleres D (2010) 2
ORC6 0 APP 1 pull down Olah J (2011) 1
ORC5 0 CDC5L 2 pull down, affinity chromatography technology Ramachandran N (2004), Lleres D (2010) 2
NTRK1 1 ORC3 3 affinity chromatography technology Emdal KB (2015) 1
HIST3H3 0 LRWD1 1 unspecified method Vermeulen M (2010) 1
MCM7 5 ORC2 0 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
KIFAP3 1 ORC3 3 affinity chromatography technology Hein MY (2015) 1
CDC5L 2 ORC6 0 affinity chromatography technology Lleres D (2010) 1
CCNE2 2 APP 1 pull down Olah J (2011) 1
NTRK1 1 PLK1 0 affinity chromatography technology Emdal KB (2015) 1
BRCA1 7 MCM4 3 affinity chromatography technology Ertych N (2016) 1
RPGR 0 LRWD1 1 affinity chromatography technology Huttlin EL (2017) 1
STN1 0 LRWD1 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
MCM4 3 ORC4 1 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
HIST3H3 0 ORC3 3 unspecified method Vermeulen M (2010) 1
TEAD2 2 ORC3 3 affinity chromatography technology Li X (2015) 1
CDC5L 2 LRWD1 1 affinity chromatography technology Lleres D (2010) 1
MCM10 2 MCM7 5 biochemical, pull down, affinity chromatography technology, affinity chromatography technology Izumi M (2000), Ramachandran N (2004), Huttlin EL (2015), Huttlin EL (2017) 4
ILF2 3 MCM4 3 affinity chromatography technology Karmakar S (2010) 1
VAPA 1 APP 1 pull down Olah J (2011) 1
XRCC5 5 BRCA1 7 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Wei L (2008), Wei L (2008), Jiang G (2013), Jiang G (2013), Jiang G (2013), Ertych N (2016) 6
STN1 0 ORC2 0 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
MCM4 3 ORC3 3 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
TEAD2 2 LRWD1 1 affinity chromatography technology Li X (2015) 1
FBXO7 1 MCM7 5 affinity chromatography technology Teixeira FR (2016) 1
NTRK1 1 ILF2 3 affinity chromatography technology Emdal KB (2015) 1
MCM7 5 APP 1 pull down, pull down Olah J (2011), Virok DP (2011) 2
KLC1 5 ORC3 3 affinity chromatography technology Hein MY (2015) 1
HIST3H3 0 ORC2 0 unspecified method Vermeulen M (2010) 1
NTRK1 1 XRCC5 5 affinity chromatography technology Emdal KB (2015) 1
ILF2 3 ORC3 3 affinity chromatography technology Karmakar S (2010) 1
HIST3H3 0 ORC5 0 unspecified method Vermeulen M (2010) 1
CDC5L 2 MCM4 3 pull down Ramachandran N (2004) 1
FOXL1 0 ORC4 1 affinity chromatography technology Li X (2015) 1
ORC4 1 ORC6 0 two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Sibani S (2005), Ramachandran N (2004) 5
XRCC6 3 ORC3 3 affinity chromatography technology, affinity chromatography technology Sibani S (2005), Sibani S (2005) 2
LRWD1 1 ORC2 0 affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015) 7
MCM4 3 ORC1 3 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
CDC45 1 MCM10 2 pull down Ramachandran N (2004) 1
CDC6 0 MCM10 2 pull down Ramachandran N (2004) 1
HIST3H3 0 HIST4H4 1 biochemical, affinity chromatography technology Campos EI (2010), Campos EI (2010) 2
MCM10 2 MCM4 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
HIST4H4 1 ORC4 1 unspecified method Vermeulen M (2010) 1
NTRK1 1 MCM10 2 affinity chromatography technology Emdal KB (2015) 1
NOP9 1 ORC3 3 affinity chromatography technology Hein MY (2015) 1
NTRK1 1 VAPA 1 affinity chromatography technology Emdal KB (2015) 1
XRCC5 5 ORC2 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Matheos D (2002), Sibani S (2005), Sibani S (2005) 3
NTRK1 1 MCM7 5 affinity chromatography technology Emdal KB (2015) 1
ORC6 0 CDC6 0 pull down Ramachandran N (2004) 1
RPGR 0 ORC3 3 affinity chromatography technology Huttlin EL (2017) 1
ORC1 3 ORC4 1 two hybrid, two hybrid, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Hein MY (2015) 3
FOXE1 2 LRWD1 1 affinity chromatography technology Li X (2015) 1
ORC1 3 ORC5 0 two hybrid, two hybrid, pull down, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015) 4
ORC3 3 BRCA1 7 affinity chromatography technology Matsuoka S (2007) 1
HIST4H4 1 ORC2 0 unspecified method Vermeulen M (2010) 1
ORC3 3 ORC5 0 two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004) 8
SNW1 0 ORC2 0 affinity chromatography technology Lleres D (2010) 1
ORC3 3 APP 1 pull down Olah J (2011) 1
CDC6 0 MCM7 5 two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013) 7
ORC2 0 ORC5 0 two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015) 13
NTRK1 1 LRWD1 1 affinity chromatography technology Emdal KB (2015) 1
SNX11 3 ORC3 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
CDC45 1 ORC3 3 pull down Ramachandran N (2004) 1
NTRK1 1 XRCC6 3 affinity chromatography technology Emdal KB (2015) 1
PLK1 0 APP 1 pull down, pull down Olah J (2011), Virok DP (2011) 2
ORC3 3 ORC4 1 biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down Dhar SK (2001), Pinto S (1999), Vashee S (2001), Sibani S (2005), Ramachandran N (2004) 5
STN1 0 ORC3 3 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
MCM7 5 ORC5 0 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
CDC45 1 MCM7 5 two hybrid, two hybrid, pull down, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Kukimoto I (1999), Liu P (2006) 4
ORC4 1 XRCC5 5 affinity chromatography technology, imaging technique Sibani S (2005), Sibani S (2005) 2
CDC6 0 ORC1 3 two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004) 7
HIST3H3 0 ORC4 1 unspecified method Vermeulen M (2010) 1
HIST4H4 1 ORC5 0 unspecified method Vermeulen M (2010) 1
MCM10 2 ORC3 3 pull down Ramachandran N (2004) 1
TERF2 2 ORC2 0 pull down, affinity chromatography technology Tatsumi Y (2008), Tatsumi Y (2008) 2
MCM7 5 ORC3 3 two hybrid, two hybrid, pull down Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004) 3
FOXL1 0 ORC2 0 affinity chromatography technology Li X (2015) 1
ORC2 0 BRCA1 7 affinity chromatography technology, affinity chromatography technology Matsuoka S (2007), Hill SJ (2014) 2
LRWD1 1 ORC3 3 biochemical, affinity chromatography technology Havugimana PC (2012), Hein MY (2015) 2
ORC2 0 ORC3 3 two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015) 17
LRWD1 1 ORC4 1 affinity chromatography technology Hein MY (2015) 1
CDC45 1 ORC1 3 two hybrid, two hybrid Kneissl M (2003), Kneissl M (2003) 2
BRCA1 7 XRCC6 3 affinity chromatography technology, affinity chromatography technology Woods NT (2012), Ertych N (2016) 2
CCNE2 2 ORC3 3 pull down Ramachandran N (2004) 1
FOXL1 0 ORC3 3 affinity chromatography technology Li X (2015) 1
CDC5L 2 ILF2 3 affinity chromatography technology, biochemical, affinity chromatography technology Ajuh P (2000), Ajuh P (2000), Huttlin EL (2015) 3
HIST4H4 1 ORC3 3 unspecified method Vermeulen M (2010) 1
FBXO7 1 CCNE2 2 enzymatic study Teixeira FR (2016) 1
LRWD1 1 ORC1 3 affinity chromatography technology, affinity chromatography technology Hein MY (2015), Hein MY (2015) 2
ORC2 0 MCM10 2 two hybrid, affinity chromatography technology, pull down Izumi M (2000), Izumi M (2000), Ramachandran N (2004) 3
NTRK1 1 TACC3 1 affinity chromatography technology Emdal KB (2015) 1
TERF2 2 XRCC5 5 affinity chromatography technology, affinity chromatography technology OConnor MS (2004), Giannone RJ (2010) 2
BRCA1 7 CDC5L 2 affinity chromatography technology Ertych N (2016) 1
CDC6 0 ORC2 0 two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004) 5
XRCC5 5 ORC6 0 affinity chromatography technology, affinity chromatography technology, imaging technique Sibani S (2005), Sibani S (2005), Sibani S (2005) 3
XRCC5 5 ORC1 3 affinity chromatography technology Matheos D (2002) 1
FOXQ1 0 ORC3 3 affinity chromatography technology Li X (2015) 1
HIST3H3 0 MCM7 5 affinity chromatography technology Campos EI (2010) 1
TACC3 1 ORC3 3 affinity chromatography technology Hein MY (2015) 1