PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IKBKG	0	RUSC1	5	affinity chromatography technology	Napolitano G (2009)	1
HNRNPH2	2	RUSC1	5	affinity chromatography technology	Hein MY (2015)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
PNMA1	0	RUSC1	5	two hybrid	Rolland T (2014)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
RUSC1	5	APP	1	pull down	Olah J (2011)	1
RUSC1	5	FAM9B	0	two hybrid	Rolland T (2014)	1
RBPMS	0	RUSC1	5	two hybrid	Rolland T (2014)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
TRAF6	0	APP	1	pull down	Olah J (2011)	1
DVL2	5	RBPMS	0	two hybrid	Rual JF (2005)	1
DVL2	5	WWP2	7	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Mund T (2015), Mund T (2015), Mund T (2015), Mund T (2015), Chaudhary N (2014)	5
UBE2S	2	RUSC1	5	affinity chromatography technology	Hein MY (2015)	1
UBE2S	2	APP	1	pull down	Olah J (2011)	1
FAM83H	6	RUSC1	5	affinity chromatography technology	Hein MY (2015)	1
WWP2	7	RUSC1	5	two hybrid	Rolland T (2014)	1
DVL2	5	RUSC1	5	two hybrid	Yu H (2011)	1
TRAF6	0	RUSC1	5	affinity chromatography technology	Napolitano G (2009)	1
STUB1	4	RUSC1	5	two hybrid	Rolland T (2014)	1