PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NSD3	6	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
MET	7	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
AKT1	1	TERT	7	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kawauchi K (2005), Kim MO (2008), Ivanov AA (2017)	3
ERBB2	6	CRK	0	unspecified method	Jones RB (2006)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
MAP2K3	1	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PDLIM7	0	LPP	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TP53	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
NF2	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D1	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kim JM (2010), Kang D (2002), Jung I (2012)	4
CBLC	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYFIP2	7	WASF2	0	biochemical	Wan C (2015)	1
CD2AP	0	CBLC	1	affinity chromatography technology, affinity chromatography technology	Tsui CC (2008), Tsui CC (2008)	2
NSD3	6	NFIC	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP2	0	CBLC	1	two hybrid	Hayes SD (2012)	1
GLIS2	2	RAF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
TRIM46	3	MDM4	0	two hybrid	Woodsmith J (2012)	1
NF2	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FGFR4	6	NSD3	6	two hybrid	Arroyo R (2015)	1
CBLC	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
ERBB2	6	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NFIC	5	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
FGFR4	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	CBLC	1	affinity chromatography technology	Takeshita K (2012)	1
CRK	0	RET	3	pull down, imaging technique	Bocciardi R (1997), Chen TC (2014)	2
CBLC	1	NCKAP1	7	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	CHFR	5	two hybrid, pull down, pull down	Markson G (2009), Chaturvedi P (2002), Liu C (2013)	3
SRC	2	RET	3	affinity chromatography technology	Melillo RM (1999)	1
TERT	7	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
CBLC	1	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography	Kim M (1999), Keane MM (1999), Keane MM (1999), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012)	6
STK11	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LYN	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Ren X (2003), Ren X (2003)	2
CBLC	1	OXA1L	3	two hybrid	Wang J (2011)	1
NFIC	5	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
CDK6	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CD2AP	0	EGFR	5	affinity chromatography technology	Lynch DK (2003)	1
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
CBLC	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FGFR4	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	SHC1	0	affinity chromatography technology	Liang Q (1998)	1
RET	3	CBLC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsui CC (2008), Tsui CC (2008), Kales SC (2014), Kales SC (2014)	4
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
CDKN2B	0	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2L6	0	CBLC	1	two hybrid	Markson G (2009)	1
STK11	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	CHFR	5	two hybrid	Woodsmith J (2012)	1
MET	7	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NSD3	6	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	PDLIM7	0	two hybrid	Rual JF (2005)	1
LATS2	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STK11	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAF1	3	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	RAF1	3	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Alexandrov I (1997), Koch HB (2007), Ivanov AA (2017)	3
CBLC	1	BRK1	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CBLC	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	CRK	0	pull down, two hybrid	Keane MM (1999), Grossmann A (2015)	2
RAF1	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	CHFR	5	enzymatic study	Kwon YE (2013)	1
MAP2K3	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAF1	3	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	FYN	1	affinity chromatography technology, pull down	Kim M (1999), Kim M (1999)	2
RAF1	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
TP53	0	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ABI2	4	CYFIP2	7	affinity chromatography technology	Huttlin EL (2017)	1
GLIS2	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
NFIC	5	GLIS2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
CDK6	0	MYC	2	enzymatic study, fluorescent resonance energy transfe	Anders L (2011), Ivanov AA (2017)	2
CBLC	1	SRC	2	affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study	Ryan PE (2010), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012), Kim M (2004), Kim M (2004)	6
AKT1	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014)	2
CBLC	1	WASF2	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
BIRC2	1	UBE2L6	0	affinity chromatography technology	Hu S (2003)	1
TP53	0	TERT	7	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
LATS2	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
CBLC	1	ZNHIT2	0	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
UBE2I	0	CD2AP	0	enzymatic study	Tossidou I (2012)	1
CBLC	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
OTUD6A	2	CBLC	1	two hybrid	Hayes SD (2012)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
STK11	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
EGFR	5	MAP2K3	1	affinity chromatography technology	Tong J (2014)	1
CBLC	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NSD3	6	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NCKAP1	7	WASF1	10	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
CCND2	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PDLIM7	0	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Jung CR (2010), Jung CR (2010), Jung CR (2010)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
GLIS2	2	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
CBLC	1	CYFIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
MET	7	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NSD3	6	CBLC	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NFIC	5	CBLC	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2R2	2	CBLC	1	two hybrid	Markson G (2009)	1
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
UBE2K	0	CBLC	1	two hybrid	Markson G (2009)	1
CYFIP1	2	WASF1	10	biochemical	Wan C (2015)	1
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
MDM4	0	UBE2D3	1	pull down	Zhu Y (2009)	1
CBLC	1	TRIP6	2	two hybrid	Ryan PE (2012)	1
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
ABI2	4	CYFIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
TP53	0	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	STK11	2	affinity chromatography technology, fluorescent resonance energy transfe	Karuman P (2001), Ivanov AA (2017)	2
TRIP6	2	SRC	2	affinity chromatography technology	Xu J (2004)	1
CYFIP2	7	WASF1	10	biochemical	Wan C (2015)	1
NCKAP1	7	BRK1	0	biochemical	Kristensen AR (2012)	1
TP53	0	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
UBE2D2	0	CHFR	5	two hybrid, pull down, pull down, pull down	Markson G (2009), Kang D (2002), Oh YM (2009), Chaturvedi P (2002)	4
RAF1	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
CBLC	1	LPP	2	affinity chromatography technology	Huttlin EL (2017)	1
CCND2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NCKAP1	7	WASF2	0	biochemical	Wan C (2015)	1
MET	7	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	SH3GL3	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CBLC	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FYN	1	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
CRK	0	UBC	7	affinity chromatography technology	Brehme M (2009)	1
LATS2	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	ABI2	4	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
ITCH	1	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Wiesner S (2007), Ishihara T (2011), Scialpi F (2008), Bai Y (2004), Oberst A (2007), Mouchantaf R (2006), Rossi M (2005), Zhang P (2010), Anindya R (2007), Kathania M (2015), Kristariyanto YA (2015), Riling C (2015), Riling C (2015), Zhang W (2016)	14
CBLC	1	SHC1	0	two hybrid	Vinayagam A (2011)	1
CBLC	1	ITCH	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Courbard JR (2002), Courbard JR (2002), Courbard JR (2002), Courbard JR (2002)	4
EPHA2	3	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	ZAP70	5	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
CBLC	1	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ABI2	4	NCKAP1	7	affinity chromatography technology	Huttlin EL (2017)	1
UBE2R2	2	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
NF2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
ERBB2	6	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	RAF1	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYFIP1	2	NCKAP1	7	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Boldt K (2016)	3
MDM4	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2D2	0	RAF1	3	enzymatic study	Demand J (2001)	1
UBE2L3	1	CBLC	1	two hybrid	Markson G (2009)	1
CBLC	1	CKM	0	enzymatic study	Ryan PE (2010)	1
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
OTUD6A	2	TRIM46	3	two hybrid	Hayes SD (2012)	1
MYC	2	PDLIM7	0	affinity chromatography technology	Agrawal P (2010)	1
CDK6	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIP6	2	ABI2	4	two hybrid	Rolland T (2014)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
ABI2	4	WASF1	10	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
BIRC2	1	RAF1	3	pull down	Dogan T (2008)	1
SHC1	0	EPHA2	3	affinity chromatography technology, pull down	Pratt RL (2002), Pratt RL (2002)	2
LATS2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	EPHA2	3	affinity chromatography technology	Tong J (2014)	1
TP53	0	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	CBLC	1	two hybrid	Markson G (2009)	1
SRC	2	MET	7	affinity chromatography technology	Rahimi N (1998)	1
CBLC	1	WASF1	10	affinity chromatography technology	Huttlin EL (2017)	1
RAF1	3	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
OTUD6A	2	UBC	7	enzymatic study	Mevissen TE (2013)	1
CBLC	1	TGFB1I1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Ryan PE (2012), Ryan PE (2012), Desai LP (2014)	3
CDK6	0	ABI2	4	enzymatic study	Anders L (2011)	1
CBLC	1	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP2	0	MYC	2	enzymatic study	Gonzalez-Prieto R (2015)	1
ZAP70	5	SHC1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Pacini S (1998), Pacini S (1998), Jin HS (2013)	3
UBE2R2	2	UBC	7	two hybrid, enzymatic study	Vinayagam A (2011), Hill S (2016)	2
CBLC	1	GAK	5	affinity chromatography technology	Huttlin EL (2017)	1
NF2	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	CD2AP	0	affinity chromatography technology	Zhou L (2015)	1
CBLC	1	MGME1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
ITCH	1	FYN	1	affinity chromatography technology, affinity chromatography technology, pull down	Yang C (2006), Yang C (2006), Yang C (2006)	3
CBLC	1	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
EPHA2	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	UBE2D1	0	pull down	Kim M (2004)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
CDK6	0	CDKN2B	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Mo XL (2015), Huttlin EL (2017), Ivanov AA (2017)	8
NF2	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	CRK	0	affinity chromatography technology	Oh YM (2014)	1
ERBB2	6	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
RAF1	3	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2H	3	CBLC	1	two hybrid	Markson G (2009)	1
ITCH	1	UBE2K	0	pull down	Sheng Y (2012)	1
ABI2	4	BRK1	0	affinity chromatography technology	Huttlin EL (2017)	1
GLIS2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM4	0	USP2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Allende-Vega N (2010), Allende-Vega N (2010), Wang CL (2014), Wang CL (2014), Wang CL (2014)	5
BIRC2	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
PDLIM7	0	RET	3	affinity chromatography technology, affinity chromatography technology	Borrello MG (2002), Kales SC (2014)	2
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
MYC	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	CYFIP2	7	affinity chromatography technology	Huttlin EL (2017)	1
CBLC	1	ZAP70	5	unspecified method	Takeshita K (2012)	1
SHC1	0	RET	3	affinity chromatography technology, pull down, affinity chromatography technology	Arighi E (1997), Arighi E (1997), Borrello MG (1994)	3
CBLC	1	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	MAP2K3	1	genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Toyoshima M (2012), Ivanov AA (2017), Ivanov AA (2017), Ivanov AA (2017)	4
UBE2D2	0	STK11	2	enzymatic study	Gaude H (2012)	1
RAF1	3	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STK11	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	UBE2D3	1	pull down	Kim M (2004)	1
USP21	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
LATS2	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
NF2	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K3	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	UBE2D3	1	two hybrid, affinity chromatography technology	Wang W (2013), Wang W (2013)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
MYC	2	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TERT	7	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYFIP1	2	WASF2	0	biochemical	Wan C (2015)	1
FGFR4	6	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	NACAD	4	two hybrid	Vinayagam A (2011)	1
MYC	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	NSD3	6	two hybrid	Weimann M (2013)	1
CCND2	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ERBB2	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LATS2	1	SRC	2	affinity chromatography technology	Si Y (2017)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
MAP2K3	1	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	CBLC	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK6	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NF2	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	CD2AP	0	pull down, x-ray crystallography	Ortega Roldan JL (2013), Ortega Roldan JL (2013)	2
CBLC	1	PDLIM7	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Kales SC (2014), Kales SC (2014), Kales SC (2014)	3
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM46	3	CBLC	1	two hybrid	Woodsmith J (2012)	1
SHC1	0	SRC	2	pull down	Schueller AC (2008)	1
SRC	2	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
ERBB2	6	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid	Schulze WX (2006), Wong L (1999), Olayioye MA (1998), Crovello CS (1998), Jones RB (2006), Yao Z (2017)	6
USP2	0	TRIM46	3	two hybrid	Hayes SD (2012)	1
RAF1	3	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP2	0	ERBB2	6	enzymatic study	Liu H (2009)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
CBLC	1	LYN	2	pull down	Keane MM (1999)	1
FGFR4	6	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TP53	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RAF1	3	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
CDK6	0	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NFIC	5	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCND2	2	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NFIC	5	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
USP21	2	CBLC	1	two hybrid	Hayes SD (2012)	1
GLIS2	2	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2B	0	TGFB1I1	2	two hybrid	Wang J (2011)	1
ABI2	4	WASF2	0	pull down, affinity chromatography technology	Hirao N (2006), Huttlin EL (2017)	2
CCND2	2	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CBLC	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GLIS2	2	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
USP2	0	ZAP70	5	enzymatic study	Naik E (2016)	1
TRAF4	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
TRAF4	1	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
EPHA2	3	CDKN2B	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ZAP70	5	FYN	1	genetic interference, affinity chromatography technology	Neumeister EN (1995), Neumeister EN (1995)	2
CDK6	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN2B	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MET	7	TERT	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
RAF1	3	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	NSD3	6	two hybrid	Arroyo R (2015)	1
CCND2	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
NCKAP1	7	CYFIP2	7	biochemical	Wan C (2015)	1
GLIS2	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CRK	0	ZAP70	5	pull down	Gelkop S (1999)	1
TRIP6	2	PDLIM7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3