PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPP1R15A	2	MUM1	1	affinity chromatography technology	Huttlin EL (2017)	1
HABP4	1	PPP1R15A	2	two hybrid	Nery FC (2006)	1
CUL3	17	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
IKBKB	1	PPP1R15A	2	affinity chromatography technology	Li HY (2008)	1
IKBKB	1	COPS5	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Orel L (2010), Orel L (2010), Orel L (2010), Orel L (2010), Asare Y (2013), Asare Y (2013)	6
PPP1R15A	2	EIF2S1	2	affinity chromatography technology	Brush MH (2003)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
CUL3	17	PPP1CB	9	affinity chromatography technology	Bennett EJ (2010)	1
PPP1R15A	2	PLEKHA1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
CUEDC2	0	PPP1CA	3	affinity chromatography technology	Li HY (2008)	1
HSPA8	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Polanowska-Grabowska R (1997), Cid C (2007)	2
PPP1R15A	2	BBX	2	affinity chromatography technology	Huttlin EL (2017)	1
CTBP2	7	PPP1R15A	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
CUL3	17	PPP1R15A	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
SMARCB1	1	PPP1CA	3	pull down, affinity chromatography technology, genetic interference	Wu DY (2002), Wu DY (2002), Wu DY (2002)	3
KMT2A	58	PPP1R15A	2	two hybrid, affinity chromatography technology	Adler HT (1999), Adler HT (1999)	2
PPP1R15A	2	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Hung WJ (2003), Wu DY (2002), Colland F (2004)	3
PPP1R15A	2	ZNF92	0	affinity chromatography technology	Huttlin EL (2017)	1
RAD21	3	PPP1R15A	2	two hybrid, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
PPP1R15A	2	PPP1CC	2	affinity chromatography technology, biochemical	Wu DY (2002), Brush MH (2004)	2
CAND1	2	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
PPP1R15A	2	10775	0	affinity chromatography technology	Huttlin EL (2017)	1
IKBKB	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li HY (2008), Mitsuhashi S (2008), Mitsuhashi S (2008)	3
LYN	2	BCAR1	6	affinity chromatography technology, affinity chromatography technology	Manie SN (1997), Qiu W (1998)	2
COPS5	0	EIF2S1	2	affinity chromatography technology	Bennett EJ (2010)	1
SMARCB1	1	PPP1CB	9	pull down, affinity chromatography technology, genetic interference	Wu DY (2002), Wu DY (2002), Wu DY (2002)	3
CAND1	2	PPP1R15A	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
SMARCB1	1	PPP1CC	2	pull down, affinity chromatography technology, genetic interference	Wu DY (2002), Wu DY (2002), Wu DY (2002)	3
COPS5	0	HSPA8	4	affinity chromatography technology	Bennett EJ (2010)	1
SMAD7	1	PPP1R15A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Shi W (2004), Shi W (2004), Shi W (2004)	3
PPP1R15A	2	SMARCB1	1	affinity chromatography technology, pull down, affinity chromatography technology	Adler HT (1999), Adler HT (1999), Wu DY (2002)	3
LYN	2	PPP1R15A	2	two hybrid, affinity chromatography technology, pull down	Grishin AV (2001), Grishin AV (2001), Grishin AV (2001)	3
COPS5	0	PPP1CC	2	affinity chromatography technology, two hybrid, two hybrid	Bennett EJ (2010), Esteves SL (2012), Fardilha M (2011)	3
PPP1R15A	2	PPP1CB	9	affinity chromatography technology	Wu DY (2002)	1
PPP1CC	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cid C (2007), Cid C (2007), Fardilha M (2011)	3
PPP1R15A	2	HSPA8	4	affinity chromatography technology	Hung WJ (2003)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
CAND1	2	EIF2S1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUEDC2	0	PPP1R15A	2	two hybrid, affinity chromatography technology	Li HY (2008), Li HY (2008)	2
PPP1R1A	1	PPP1R15A	2	two hybrid, pull down, affinity chromatography technology	Connor JH (2001), Connor JH (2001), Connor JH (2001)	3
ZNF512B	2	PPP1R15A	2	two hybrid	Colland F (2004)	1
RAD21	3	EIF2S1	2	affinity chromatography technology	Panigrahi AK (2011)	1
BCAR1	6	PPP1R15A	2	two hybrid	Stelzl U (2005)	1
COPS5	0	PPP1R15A	2	affinity chromatography technology	Bennett EJ (2010)	1
KMT2A	58	SMARCB1	1	affinity chromatography technology, affinity chromatography technology	Adler HT (1999), Nakamura T (2002)	2
PPP1R15A	2	TSN	1	two hybrid, pull down	Hasegawa T (1999), Hasegawa T (1999)	2
CAND1	2	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PPP1CA	3	affinity chromatography technology	Bennett EJ (2010)	1
CUEDC2	0	IKBKB	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Li HY (2008), Li HY (2008), Li HY (2008)	3
SMAD7	1	COPS5	0	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Kim BC (2004), Kim BC (2004), Kim BC (2004), Kim BC (2004)	4
PPP1R15A	2	BAG1	1	two hybrid, pull down, affinity chromatography technology	Hung WJ (2003), Hung WJ (2003), Hung WJ (2003)	3
ZNF512B	2	CTBP2	7	two hybrid	Colland F (2004)	1
PPP1R15A	2	MINK1	6	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CUL3	17	IKBKB	1	affinity chromatography technology	Lee DF (2009)	1
BAG1	1	HSPA8	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, two hybrid, pull down, affinity chromatography technology	Takayama S (1997), Takayama S (1999), Takayama S (1999), Takayama S (1997), Takayama S (1997), Elliott E (2007), Alberti S (2002), Tsukahara F (2010), Brive L (2001), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Townsend PA (2004), Sharp A (2009), Sharp A (2009), Sondermann H (2001), Gebauer M (1998), Rolland T (2014), Mock JY (2015), Karras GI (2017)	20
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12