PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCND2	2	KCNIP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, biochemical	Foeger NC (2010), Baehring R (2001), Dementieva IS (2009), Levy DI (2010), An WF (2000), Lin YL (2004), Kim LA (2004), Kim LA (2004), Kim LA (2004)	9
FLNA	10	KCND2	2	affinity chromatography technology	Levy DI (2010)	1
OBSL1	9	FLNA	10	affinity chromatography technology	Hanson D (2014)	1
KCNE4	1	TSNAX	1	two hybrid	Levy DI (2010)	1
KCNE4	1	OBSL1	9	two hybrid	Levy DI (2010)	1
KCND2	2	KCNE4	1	pull down, affinity chromatography technology	Levy DI (2010), Levy DI (2010)	2
FLNA	10	KCNE4	1	affinity chromatography technology, two hybrid	Levy DI (2010), Levy DI (2010)	2
KCNE4	1	KCNIP2	0	affinity chromatography technology, affinity chromatography technology	Levy DI (2010), Levy DI (2010)	2