PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	CHD4	22	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
C1QBP	0	MRPS34	0	affinity chromatography technology	Yagi M (2012)	1
BRD1	5	YWHAG	5	affinity chromatography technology	Fryland T (2016)	1
CHD4	22	CHD3	19	affinity chromatography technology, affinity chromatography technology, biochemical	Xue Y (1998), Xue Y (1998), Havugimana PC (2012)	3
NSUN2	0	NPM1	0	affinity chromatography technology, affinity chromatography technology	Sakita-Suto S (2007), Hein MY (2015)	2
H3F3A	1	CHD4	22	affinity chromatography technology	Heo K (2007)	1
NPM1	0	HIST3H3	0	far western blotting	Okuwaki M (2001)	1
ING5	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Huttlin EL (2017)	3
CHD4	22	HIST1H3A	3	unspecified method, x-ray crystallography, x-ray crystallography, unspecified method	Mansfield RE (2011), Mansfield RE (2011), Allen HF (2014), Allen HF (2014)	4
BRD1	5	MRPS14	0	affinity chromatography technology	Fryland T (2016)	1
DNMT1	5	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Cui S (2011), Cui S (2011), Cai Y (2014), Cai Y (2014), Cai Y (2014), Cai Y (2014)	6
YWHAG	5	C1QBP	0	affinity chromatography technology	Jin J (2004)	1
H2AFX	1	HIST2H3C	0	affinity chromatography technology	Dittmann K (2011)	1
H2AFX	1	BRD1	5	pull down	Lee HS (2010)	1
TMPO	0	KAT7	3	affinity chromatography technology	Hein MY (2015)	1
IFI16	1	BRD1	5	affinity chromatography technology	Diner BA (2015)	1
BRD1	5	HIST3H3	0	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	CEP126	0	two hybrid	Stelzl U (2005)	1
TRIM25	5	FEZ2	0	affinity chromatography technology	Choudhury NR (2017)	1
NPM1	0	C1QBP	0	affinity chromatography technology	Chen R (2013)	1
TRIM25	5	ING5	3	affinity chromatography technology	Choudhury NR (2017)	1
KAT7	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
TMPO	0	CLTC	12	affinity chromatography technology	Brady GF (2018)	1
YWHAZ	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Tzivion G (2000), Tzivion G (2000), Tzivion G (2000)	3
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
BRD1	5	NSUN2	0	affinity chromatography technology	Fryland T (2016)	1
TMPO	0	PHB2	1	affinity chromatography technology	Hein MY (2015)	1
8339	0	KAT7	3	bioid	Lambert JP (2015)	1
BRD1	5	RPL22L1	0	affinity chromatography technology	Fryland T (2016)	1
PBRM1	5	HIST1H3A	3	x-ray crystallography, unspecified method, bioid	Charlop-Powers Z (2010), Charlop-Powers Z (2010), Lambert JP (2015)	3
RPL10	3	BRD1	5	affinity chromatography technology	Hein MY (2015)	1
TAL1	0	CHD3	19	affinity chromatography technology, two hybrid	Hu X (2009), Goehler H (2004)	2
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
ING4	1	HIST1H3A	3	x-ray crystallography, pull down	Palacios A (2010), Moreno A (2010)	2
NPM1	0	KPNA1	5	biochemical	Kristensen AR (2012)	1
CHD5	12	HIST3H3	0	affinity chromatography technology	Quan J (2014)	1
FEZ1	0	BRD1	5	two hybrid	Assmann EM (2006)	1
CNTROB	6	RPL10	3	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	EIF3I	0	affinity chromatography technology	Chen R (2013)	1
BRD1	5	CLTC	12	affinity chromatography technology	Fryland T (2016)	1
ZNF512B	2	PBRM1	5	two hybrid	Colland F (2004)	1
KAT7	3	BRD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Fryland T (2016)	2
YWHAE	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
BRD1	5	VIM	0	two hybrid	Stelzl U (2005)	1
CLTC	12	PHB2	1	biochemical	Wan C (2015)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TAL1	0	BRD1	5	affinity chromatography technology	Goardon N (2006)	1
ING4	1	HIST2H3C	0	x-ray crystallography	Palacios A (2008)	1
S100A4	0	BRD1	5	affinity chromatography technology	Hein MY (2015)	1
BRD1	5	CHD4	22	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	YWHAE	0	affinity chromatography technology	Fryland T (2016)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
TRIM25	5	BRD1	5	affinity chromatography technology	Choudhury NR (2017)	1
FEZ2	0	KPNA2	0	two hybrid	Wang J (2011)	1
BRD1	5	KPNA1	5	affinity chromatography technology	Fryland T (2016)	1
RPL10	3	LYAR	0	affinity chromatography technology	Hein MY (2015)	1
ZNF512B	2	BRD1	5	two hybrid	Colland F (2004)	1
H2AFX	1	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Huttlin EL (2015), Huttlin EL (2017)	4
FEZ2	0	BRD1	5	two hybrid	Assmann EM (2006)	1
BRD1	5	YWHAB	1	affinity chromatography technology	Fryland T (2016)	1
H2AFX	1	YWHAE	0	affinity chromatography technology	Yang X (2010)	1
TRIM25	5	C1QBP	0	affinity chromatography technology	Choudhury NR (2017)	1
RPL10	3	MEAF6	0	affinity chromatography technology	Hein MY (2015)	1
LYAR	0	NPM1	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015)	2
ING5	3	BRD1	5	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Fryland T (2016)	2
IFI16	1	LYAR	0	affinity chromatography technology	Diner BA (2015)	1
8339	0	BRD1	5	bioid	Lambert JP (2015)	1
8339	0	ZNF512B	2	bioid	Lambert JP (2015)	1
NPM1	0	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan V (2005), Haindl M (2008), Shuaib M (2010), Shuaib M (2010)	4
8339	0	YWHAB	1	bioid	Lambert JP (2015)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
YWHAB	1	C1QBP	0	affinity chromatography technology	Jin J (2004)	1
PBRM1	5	HIST3H3	0	affinity chromatography technology	Chandrasekaran R (2007)	1
CNTROB	6	BRD1	5	affinity chromatography technology	Hein MY (2015)	1
BRD1	5	EIF3I	0	affinity chromatography technology	Fryland T (2016)	1
KPNA2	0	KPNA1	5	biochemical	Wan C (2015)	1
RPL10	3	DRG1	1	affinity chromatography technology	Hein MY (2015)	1
BRD1	5	NPM1	0	affinity chromatography technology	Fryland T (2016)	1
TMPO	0	VIM	0	affinity chromatography technology	Brady GF (2018)	1
BRD1	5	DRG1	1	affinity chromatography technology	Fryland T (2016)	1
H2AFX	1	S100A4	0	affinity chromatography technology	Yang X (2010)	1
KPNA2	0	PHB2	1	affinity chromatography technology	Kim NH (2015)	1
CHD4	22	CHD5	12	affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Quan J (2014)	2
C1QBP	0	PHB2	1	affinity chromatography technology	Yagi M (2012)	1
IFI16	1	PBRM1	5	affinity chromatography technology	Diner BA (2015)	1
BRD1	5	YWHAH	0	affinity chromatography technology	Fryland T (2016)	1
YWHAZ	1	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Zippo A (2009), Macdonald N (2005), Macdonald N (2005), Macdonald N (2005), Macdonald N (2005)	5
KPNA1	5	PHB2	1	affinity chromatography technology	Kim NH (2015)	1
BRD1	5	DNMT1	5	affinity chromatography technology	Fryland T (2016)	1
YWHAE	0	TMPO	0	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Brady GF (2018)	2
LYAR	0	EIF3I	0	affinity chromatography technology	Ewing RM (2007)	1
YWHAZ	1	CEP126	0	two hybrid	Stelzl U (2005)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
HIST1H3A	3	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wysocka J (2006), Nishioka K (2002), Klement K (2014)	3
BRD1	5	HIST2H3C	0	unspecified method	Wu H (2011)	1
ZC3H15	2	DRG1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Ishikawa K (2005), Ishikawa K (2005), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	7
BRD1	5	CHD3	19	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	NAP1L4	3	affinity chromatography technology	Fryland T (2016)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
FEZ1	0	FEZ2	0	two hybrid	Assmann EM (2006)	1
NPM1	0	RPL10	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen R (2013), Hein MY (2015), Hein MY (2015)	3
HIST1H3A	3	ZNF512B	2	bioid	Lambert JP (2015)	1
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
LYAR	0	KPNA1	5	affinity chromatography technology	Ewing RM (2007)	1
TMPO	0	RPL10	3	affinity chromatography technology	Brady GF (2018)	1
TRIM25	5	KPNA2	0	affinity chromatography technology	Choudhury NR (2017)	1
BRD1	5	QSER1	7	affinity chromatography technology	Fryland T (2016)	1
ING4	1	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Hein MY (2015), Huttlin EL (2017)	3
RPL10	3	IFI16	1	affinity chromatography technology	Hein MY (2015)	1
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
H2AFX	1	YWHAB	1	affinity chromatography technology	Yang X (2010)	1
TRIM25	5	RPL10	3	affinity chromatography technology	Choudhury NR (2017)	1
BRD1	5	PHB2	1	affinity chromatography technology	Fryland T (2016)	1
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
BRD1	5	YWHAZ	1	affinity chromatography technology	Fryland T (2016)	1
VIM	0	ING5	3	two hybrid	Goehler H (2004)	1
CHD4	22	HIST3H3	0	unspecified method, unspecified method, affinity chromatography technology	Morra R (2012), Vermeulen M (2010), Quan J (2014)	3
BRD1	5	KMT5B	16	affinity chromatography technology	Fryland T (2016)	1
KAT7	3	HIST1H3A	3	enzymatic study	Zong H (2005)	1
BRD1	5	C1QBP	0	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	MEAF6	0	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	H3F3A	1	pull down, affinity chromatography technology	Qin S (2011), Fryland T (2016)	2
RPL10	3	CHD3	19	affinity chromatography technology	Hein MY (2015)	1
BRD1	5	MRPS34	0	affinity chromatography technology	Fryland T (2016)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
KAT7	3	ING5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Huttlin EL (2017)	6
BRD1	5	LYAR	0	affinity chromatography technology	Fryland T (2016)	1
YWHAB	1	HIST1H3A	3	pull down	Macdonald N (2005)	1
MRPS34	0	MRPS14	0	affinity chromatography technology	Huttlin EL (2017)	1
TAL1	0	DRG1	1	two hybrid	Zhao XF (1998)	1
ING4	1	HIST3H3	0	x-ray crystallography, pull down	Palacios A (2006), Varier RA (2010)	2
NPM1	0	YWHAZ	1	affinity chromatography technology	Chen R (2013)	1
TRIM25	5	CHD3	19	affinity chromatography technology	Choudhury NR (2017)	1
DNMT1	5	HIST3H3	0	affinity chromatography technology	Qin W (2015)	1
RPL10	3	NSUN2	0	affinity chromatography technology	Hein MY (2015)	1
YWHAE	0	NPM1	0	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Chen R (2013)	2
HIST1H3A	3	YWHAG	5	affinity chromatography technology, pull down	Macdonald N (2005), Macdonald N (2005)	2
TMPO	0	BRD1	5	affinity chromatography technology	Hein MY (2015)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
BRD1	5	KPNA2	0	affinity chromatography technology	Fryland T (2016)	1
H2AFX	1	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Yang X (2010), Yang X (2010)	2
NAP1L4	3	HIST3H3	0	pull down	Rodriguez P (1997)	1
RPL10	3	EIF3I	0	affinity chromatography technology	Hein MY (2015)	1
TAL1	0	CHD4	22	affinity chromatography technology	Hu X (2009)	1
NPM1	0	CLTC	12	affinity chromatography technology	Chen R (2013)	1
BRD1	5	ZC3H15	2	affinity chromatography technology	Fryland T (2016)	1
BRD1	5	CHD5	12	affinity chromatography technology	Fryland T (2016)	1
ING4	1	KAT7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Culurgioni S (2012), Hein MY (2015)	6
BRD1	5	PBRM1	5	affinity chromatography technology	Fryland T (2016)	1
IFI16	1	KAT7	3	affinity chromatography technology	Diner BA (2015)	1
YWHAE	0	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zippo A (2009), Macdonald N (2005), Macdonald N (2005)	3
ING4	1	BRD1	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Fryland T (2016)	2
VIM	0	KAT7	3	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Goehler H (2004)	4
MYH6	12	BRD1	5	affinity chromatography technology	Hein MY (2015)	1
NAP1L4	3	NPM1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
TRIM25	5	NAP1L4	3	affinity chromatography technology	Choudhury NR (2017)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
BRD1	5	SS18L1	2	two hybrid	Ravasi T (2010)	1
S100A4	0	KAT7	3	affinity chromatography technology	Hein MY (2015)	1
HIST1H3A	3	BRD1	5	bioid, affinity chromatography technology	Lambert JP (2015), Fryland T (2016)	2
YWHAG	5	VIM	0	affinity chromatography technology	Jin J (2004)	1
NAP1L4	3	HIST2H3C	0	pull down	Shikama N (2000)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3