PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ISG15	0	IFIT1	0	affinity chromatography technology, affinity chromatography technology	Zhao C (2005), Zhao C (2005)	2
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
EGFR	5	LONP1	9	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Yao Z (2017)	2
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
MAST1	9	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	IFIT5	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Pichlmair A (2011)	2
SRPK2	1	CHUK	5	enzymatic study	Varjosalo M (2013)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
ELAVL1	0	CRKL	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ECSIT	3	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Wi SM (2014), Wi SM (2014)	2
CDC37	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
SRPK2	1	IFIT5	0	enzymatic study	Varjosalo M (2013)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	IKBKB	1	affinity chromatography technology	Zheng C (2015)	1
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	RNF41	2	affinity chromatography technology	Huttlin EL (2017)	1
IFIT3	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MED4	2	IFIT5	0	bioid	Lambert JP (2015)	1
USP33	1	IFIT5	0	affinity chromatography technology	Sowa ME (2009)	1
IFIT1	0	IFIT3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid	Rual JF (2005), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Pichlmair A (2011), Rolland T (2014), Yu H (2011)	8
EGFR	5	MAST1	9	protein complementation assay	Deribe YL (2009)	1
RNF32	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
CHUK	5	CDC37	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Li J (2013)	5
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
A2M	8	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	SRPK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
IFIT5	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
MED4	2	A2M	8	affinity chromatography technology	Lambert JP (2015)	1
IFIT5	0	KCTD6	2	affinity chromatography technology	Huttlin EL (2017)	1
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	CHUK	5	affinity chromatography technology, pull down	Zheng C (2015), Zheng C (2015)	2
ELAVL1	0	CHUK	5	affinity chromatography technology	Chu PC (2012)	1
A2M	8	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	MED4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SRPK1	2	IFIT5	0	enzymatic study	Varjosalo M (2013)	1
ELAVL1	0	RNF41	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ISG15	0	ELAVL1	0	affinity chromatography technology	Zhao C (2005)	1
IFIT5	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
APOE	1	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	DMD	6	affinity chromatography technology	Huttlin EL (2017)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
SRPK1	2	CHUK	5	enzymatic study	Varjosalo M (2013)	1
APOE	1	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
ISG15	0	IFIT5	0	affinity chromatography technology	Zhao C (2005)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
MAST1	9	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	IKBKG	0	affinity chromatography technology, pull down	Zheng C (2015), Zheng C (2015)	2
IKBKB	1	CDC37	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ELAVL1	0	USP33	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MED4	2	MAP3K7	2	affinity chromatography technology	Lambert JP (2015)	1
CDC37	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	IFIT5	0	affinity chromatography technology	Tong J (2014)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	MAP3K7	2	affinity chromatography technology	Zheng C (2015)	1
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	IFIT3	1	two hybrid, pull down, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
IFIT5	0	CRKL	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
LIN28A	1	IFIT5	0	affinity chromatography technology	Li S (2014)	1
MAP3K7	2	CDC37	0	affinity chromatography technology	Liu XY (2008)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
IKBKG	0	SRPK1	2	pull down	Fenner BJ (2010)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
IFIT1	0	IFIT5	0	affinity chromatography technology, pull down	Pichlmair A (2011), Pichlmair A (2011)	2
ISG15	0	IFIT3	1	affinity chromatography technology	Zhao C (2005)	1
ELAVL1	0	IFIT5	0	affinity chromatography technology	Abdelmohsen K (2009)	1