Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
FSHR 2492 CHORIOGONADOTROPIN ALFA CHEMBL1201464 binder TdgClinicalTrial, TEND, TTD
FSHR 2492 MENOTROPINS CHEMBL2108427 agonist, binder TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11752352, 17139284, 17016423, 7872378, 14680547
FSHR 2492 HUMAN FSH CHEMBL1201692 agonist, binder PharmGKB, DrugBank, ChemblInteractions, TTD, TdgClinicalTrial, TEND 2108722, 7755615, 8070368, 11752352, 18020563, 8319832, 11299519
FSHR 2492 UROFOLLITROPIN CHEMBL1201520 agonist, binder PharmGKB, TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 2108722, 11752352, 8070368, 7755615, 8319832, 11299519
FSHR 2492 CORIFOLLITROPIN ALFA CHEMBL2108185 TdgClinicalTrial
FSHR 2492 ISOSORBIDE DINITRATE CHEMBL6622 agonist GuideToPharmacologyInteractions
FSHR 2492 SURAMIN CHEMBL265502 antagonist DrugBank, TTD 18991754, 17552360
FSHR 2492 THYROTROPIN ALFA CHEMBL1201533 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
FSHR rs6166 T follitropin beta toxicity not stated The ovarian hyperstimulation syndrome incidence was 6% (36 cases): 13 with the AA and 23 with the AG and no cases with the GG genotype. The N680S polymorphism was associated with ovarian hyperstimulation syndrome (Ptrend = 0.004 and Pallele = 0.038), with carriers of asparagine having an odds ratio for ovarian hyperstimulation syndrome of 1.7, 95% confidence interval: 1.0–2.8, P = 0.04, in comparison with carriers of serine. Allele T is associated with increased response to follitropin beta or urofollitropin as compared to allele C. 30829738 1450372589