PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NSD1	25	NR5A2	4	two hybrid	Chan CM (2013)	1
NCOA3	3	NR5A2	4	two hybrid	Lee YK (2002)	1
GPS2	0	CREB1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	NR5A2	4	enzymatic study, enzymatic study	Yang SH (2006), Ogawa H (2009)	2
PPARGC1A	3	NRIP1	4	affinity chromatography technology	Rytinki MM (2009)	1
NR5A2	4	CREB1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Hadizadeh S (2008), Hadizadeh S (2008), Hadizadeh S (2008)	3
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
NR5A2	4	PNRC1	0	two hybrid	Albers M (2005)	1
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
UBE2I	0	PPARGC1A	3	enzymatic study	Rytinki MM (2009)	1
GPS2	0	NR5A2	4	affinity chromatography technology	Sanyal S (2007)	1
UBE2I	0	NR1I2	5	enzymatic study	Hu G (2010)	1
UBE2I	0	EDF1	0	enzymatic study	Jakobs A (2007)	1
NR1I2	5	NCOA3	3	two hybrid	Johnson DR (2006)	1
NR5A2	4	FTH1	0	two hybrid	Albers M (2005)	1
ALB	1	NCOA3	3	affinity chromatography technology	Zhou M (2004)	1
NR5A2	4	NR0B2	1	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Brendel C (2002), Brendel C (2002), Lee YK (2002), Chanda D (2010), Kanamaluru D (2011), Zhou T (2010), Miao J (2011), Park YY (2004)	8
NCOA3	3	NR0B2	1	two hybrid	Lee YK (2002)	1
GPS2	0	NR0B2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Sanyal S (2007), Sanyal S (2007), Sanyal S (2007), Sanyal S (2007)	4
EDF1	0	NR5A2	4	pull down	Brendel C (2002)	1
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
NR0B2	1	NR1I2	5	two hybrid, pull down	Li T (2006), Li T (2006)	2
NR5A2	4	ILF3	5	affinity chromatography technology	Ohno M (2011)	1
NR5A2	4	NPPA	1	two hybrid	Albers M (2005)	1
NR5A2	4	ALB	1	two hybrid	Albers M (2005)	1
RAD54L2	5	UBE2I	0	two hybrid	Domanskyi A (2006)	1
NR5A2	4	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2
NR1I2	5	NR5A2	4	two hybrid	Li T (2005)	1
NR5A2	4	NRIP1	4	two hybrid	Albers M (2005)	1
NR5A2	4	BCKDK	2	two hybrid	Albers M (2005)	1
PPARGC1A	3	NR5A2	4	affinity chromatography technology	Yazawa T (2010)	1
RAD54L2	5	NR5A2	4	pull down	Ogawa H (2009)	1
NR5A2	4	PNRC2	0	two hybrid	Albers M (2005)	1
PPARGC1A	3	NR1I2	5	pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Bhalla S (2004), Bhalla S (2004), Bhalla S (2004), Albers M (2005), Li T (2006), Li T (2006), Li T (2005)	7
NR1I2	5	NCOA1	6	x-ray crystallography, two hybrid, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Watkins RE (2003), Rana R (2013), Takeshita A (2002), Pondugula SR (2009), Albers M (2005), Lim YP (2007), Lim YP (2007), Wang H (2008), Li T (2006), Li T (2006), Li T (2005)	11