PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST1H3A	3	DDB1	6	affinity chromatography technology, pull down	Higa LA (2006), Higa LA (2006)	2
BRCA1	7	HNRNPU	12	affinity chromatography technology	Ertych N (2016)	1
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
USP7	14	HIST2H2BE	1	affinity chromatography technology	Lecona E (2015)	1
USP7	14	HIST2H2AC	1	affinity chromatography technology, enzymatic study	Lecona E (2015), Yu M (2016)	2
BRCA1	7	CAPZB	2	affinity chromatography technology	Woods NT (2012)	1
DCAF7	4	DYRK1B	1	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Varjosalo M (2013), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Hauri S (2016)	9
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
RNF169	1	DDB1	6	affinity chromatography technology	An L (2017)	1
BRCA1	7	DCAF7	4	affinity chromatography technology	Ertych N (2016)	1
HIST2H2AC	1	HIST1H3A	3	pull down, pull down, pull down	Hoffmann A (1996), Hoffmann A (1996), Boenisch C (2012)	3
BRCA1	7	DYRK1A	36	affinity chromatography technology	Ertych N (2016)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
RNF169	1	RPS3	0	affinity chromatography technology	An L (2017)	1
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
RNF169	1	UBE2E1	1	pull down	Poulsen M (2012)	1
8339	0	RNF169	1	bioid	Lambert JP (2015)	1
CDC14B	1	C1QBP	0	bioid	St-Denis N (2016)	1
BRCA1	7	UBE2E1	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5
BRCA1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
BRCA1	7	RPS3	0	affinity chromatography technology	Ertych N (2016)	1
RNF169	1	HIST2H2BE	1	affinity chromatography technology	Panier S (2012)	1
RNF169	1	CAPZB	2	affinity chromatography technology	An L (2017)	1
USP7	14	RNF169	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Hein MY (2015), An L (2017), An L (2017), An L (2017), An L (2017), An L (2017)	6
RNF169	1	C1QBP	0	affinity chromatography technology	An L (2017)	1
HIST2H2BE	1	UBC	7	pull down	Long L (2014)	1
RNF169	1	UBC	7	pull down, pull down	Panier S (2012), Chen J (2012)	2
BRCA1	7	CAPZA1	2	affinity chromatography technology	Ertych N (2016)	1
IL16	2	RNF169	1	affinity chromatography technology	Huttlin EL (2017)	1
DYRK1B	1	DDB1	6	affinity chromatography technology	Varjosalo M (2013)	1
UBC	7	HNRNPU	12	affinity chromatography technology	Matsumoto M (2005)	1
KLHDC2	1	RNF169	1	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
DCAF7	4	RNF169	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), An L (2017)	2
HNRNPU	12	RPS3	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
DYRK1B	1	RNF169	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), An L (2017)	2
RNF169	1	HNRNPU	12	affinity chromatography technology	An L (2017)	1
RNF169	1	TUBB4B	6	affinity chromatography technology	An L (2017)	1
RNF169	1	CAPZA1	2	affinity chromatography technology	An L (2017)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
DYRK1A	36	RNF169	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), An L (2017), An L (2017)	3
UBC	7	RPS3	0	pull down	Zhang X (2017)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
RNF169	1	HIST2H2AC	1	affinity chromatography technology	Panier S (2012)	1
CDC14B	1	RNF169	1	bioid	St-Denis N (2016)	1
HIST1H3A	3	RNF169	1	bioid	Lambert JP (2015)	1
BRCA1	7	RNF169	1	affinity chromatography technology	Hill SJ (2014)	1
DDB1	6	DCAF7	4	affinity chromatography technology	Jin J (2006)	1
BRCA1	7	TUBB4B	6	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	HIST2H2AC	1	enzymatic study, enzymatic study	Chen A (2002), Thakar A (2010)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
CAPZB	2	CAPZA1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
DYRK1A	36	HIST1H3A	3	enzymatic study	Himpel S (2000)	1
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6