PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRK	0	FGFR1	2	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Larsson H (1999), Larsson H (1999)	3
GAB1	3	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schaeper U (2000), Fixman ED (1997), Fixman ED (1997)	3
EGFR	5	PTPRA	3	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
FGFR1	2	SHC1	0	pull down, affinity chromatography technology	Klint P (1995), Vecchione A (2007)	2
ERBB2	6	CRK	0	unspecified method	Jones RB (2006)	1
ERBB2	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Vogel W (1996)	5
CDH1	4	FRS2	0	bioid	Guo Z (2014)	1
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
MAP3K3	3	MARK2	6	affinity chromatography technology	Bouwmeester T (2004)	1
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
CRK	0	GAB1	3	affinity chromatography technology	Brehme M (2009)	1
MAP3K3	3	GAB1	3	affinity chromatography technology, pull down	Che W (2002), Che W (2002)	2
NTRK1	1	GAB2	3	affinity chromatography technology	Emdal KB (2015)	1
PARD3	5	PRKCI	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Yang Z (2012)	5
ARHGAP32	11	EGFR	5	affinity chromatography technology	Nakamura T (2002)	1
FGFR1	2	PTPN11	20	affinity chromatography technology	Vecchione A (2007)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
ARHGAP32	11	PIK3R1	6	affinity chromatography technology	Moon SY (2003)	1
TRIM15	0	CRK	0	protein complementation assay, affinity chromatography technology	Lee OH (2015), Lee OH (2015)	2
GAB1	3	PTPN11	20	affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saito Y (2002), Rocchi S (1998), Ingham RJ (1998), Ingham RJ (1998), van den Akker E (2004), Kapoor GS (2004), Kapoor GS (2004), Kapoor GS (2010), Fan YX (2013)	9
FGFR1	2	FRS2	0	pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, x-ray crystallography, enzymatic study, affinity chromatography technology	Yan KS (2002), Ong SH (2000), Xu H (1998), Xu H (1998), Dhalluin C (2000), Dhalluin C (2000), Larsson H (1999), Vecchione A (2007)	8
PTPRA	3	GRB2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	den Hertog J (1996), den Hertog J (1996), den Hertog J (1994), den Hertog J (1994), Zheng XM (2002), Brehme M (2009), Li J (2013), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Wang J (2013), Wang J (2013)	12
CDH1	4	CRKL	1	bioid	Guo Z (2014)	1
FRS2	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ong SH (1996), Wong A (2002), Meakin SO (1999), Kouhara H (1997), Mason JM (2004), Liu BA (2012), Lao DH (2006), Bisson N (2011), Zhou L (2015)	9
PRKCI	1	FRS2	0	two hybrid, pull down	Lim YP (1999), Lim YP (1999)	2
PTPRA	3	GAB1	3	bioid	St-Denis N (2016)	1
CDH1	4	BAG3	4	bioid	Guo Z (2014)	1
DYNLT1	3	GAB1	3	bioid	Gupta GD (2015)	1
FRS2	0	NTRK1	1	pull down, two hybrid	Meakin SO (1999), Meakin SO (1999)	2
CASP1	1	GAB1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	GAB1	3	bioid	Guo Z (2014)	1
EGFR	5	MAP3K3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
MET	7	SHC1	0	affinity chromatography technology	Liang Q (1998)	1
NTRK1	1	CRKL	1	affinity chromatography technology	Emdal KB (2015)	1
MST1R	4	SHC1	0	affinity chromatography technology	Iwama A (1996)	1
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
ARHGAP32	11	GAB1	3	affinity chromatography technology	Zhao C (2003)	1
PLCG1	6	ERBB2	6	affinity chromatography technology, biochemical, unspecified method	Peles E (1991), Arteaga CL (1991), Jones RB (2006)	3
GAB2	3	MET	7	affinity chromatography technology	Schaeper U (2000)	1
CRKL	1	GAB1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Sakkab D (2000), Sakkab D (2000), Chen TC (2014)	3
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
EGLN3	0	CRKL	1	affinity chromatography technology	Rodriguez J (2016)	1
CDH1	4	PARD3	5	bioid	Guo Z (2014)	1
GAB2	3	MARK2	6	affinity chromatography technology, affinity chromatography technology	Yang Z (2012), Yang Z (2012)	2
CDH1	4	MET	7	affinity chromatography technology, affinity chromatography technology	Davies G (2001), Davies G (2001)	2
FGFR1	2	GAB1	3	affinity chromatography technology	Vecchione A (2007)	1
CRK	0	ARHGAP32	11	pull down, affinity chromatography technology, affinity chromatography technology	Zhao C (2003), Zhao C (2003), Moon SY (2003)	3
BAG3	4	PLCG1	6	affinity chromatography technology, pull down, pull down	Doong H (2000), Doong H (2000), Gentilella A (2011)	3
TRIM15	0	GAB1	3	protein complementation assay	Lee OH (2015)	1
PTPN11	20	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boudot C (2002), Boudot C (2002), Lynch DK (2002), Zhao C (1999), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Cholay M (2010), van den Akker E (2004), Arnaud M (2004), Arnaud M (2004), Yu WM (2006), Yu WM (2006)	13
PIK3R1	6	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang S (1999), Takahashi Y (1999), Craddock BL (1997), Wu CJ (2000), Wu CJ (2001), Yu WM (2006)	6
CRKL	1	PTPN11	20	affinity chromatography technology	Chin H (1997)	1
CRKL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down	Gesbert F (1998), Gelkop S (2001), Ren SY (2005)	3
GRB2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006)	21
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
ARHGAP32	11	SHC1	0	affinity chromatography technology	Nakamura T (2002)	1
EGFR	5	TUFM	1	affinity chromatography technology	Yao Z (2017)	1
ERBB2	6	GAB1	3	enzymatic study	Fan YX (2013)	1
BAG3	4	GAB1	3	affinity chromatography technology	Chen Y (2013)	1
GAB1	3	GTF2A1L	0	two hybrid	Rolland T (2014)	1
GAB2	3	ARHGAP32	11	two hybrid, affinity chromatography technology	Zhao C (2003), Zhao C (2003)	2
MARK2	6	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Suzuki A (2004)	2
NTRK1	1	GAB1	3	affinity chromatography technology	Emdal KB (2015)	1
PIK3R1	6	GAB1	3	pull down, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, affinity chromatography technology	Bertagnolo V (1998), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Rocchi S (1998), Ingham RJ (1998), Ingham RJ (1998), Fan YX (2013)	7
TUFM	1	GAB1	3	affinity chromatography technology	Huttlin EL (2017)	1
GAB1	3	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting	Ueno E (2001), Ueno E (2001), Holgado-Madruga M (1996), Holgado-Madruga M (1996)	4
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
CDH1	4	ARHGAP32	11	bioid	Guo Z (2014)	1
GRB2	2	MST1R	4	pull down, affinity chromatography technology	Li BQ (1995), Iwama A (1996)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
BAG3	4	CRKL	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
EGFR	5	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study	Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996)	7
NTRK1	1	PIK3R1	6	affinity chromatography technology	Emdal KB (2015)	1
ARHGAP32	11	PLCG1	6	affinity chromatography technology	Moon SY (2003)	1
GAB2	3	GAB1	3	two hybrid	van den Akker E (2004)	1
EGFR	5	GRAP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TRIM15	0	ROCK1	6	protein complementation assay	Lee OH (2015)	1
CRKL	1	SHC1	0	affinity chromatography technology	Chin H (1997)	1
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
EGLN3	0	PARD3	5	affinity chromatography technology	Rodriguez J (2016)	1
GRAP2	0	GAB2	3	pull down, affinity chromatography technology, affinity chromatography technology	Berry DM (2002), Huttlin EL (2015), Huttlin EL (2017)	3
BAG3	4	GRB2	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
GAB2	3	CRKL	1	affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology	Crouin C (2001), Crouin C (2001), Crouin C (2001), Schaeper U (2000)	4
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
ERBB2	6	PTPRA	3	affinity chromatography technology	Yao Z (2017)	1
SHC1	0	PIK3R1	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010)	6
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
FGFR1	2	PARD3	5	affinity chromatography technology	Vecchione A (2007)	1
GAB2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down	Lynch DK (2002), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Ren SY (2005), Momose H (2003)	6
GAB1	3	SYP	0	pull down	Lehr S (1999)	1
NTRK1	1	ROCK1	6	affinity chromatography technology	Emdal KB (2015)	1
GRAP2	0	ERBB2	6	unspecified method, imaging technique	Jones RB (2006), Chen TC (2014)	2
CRK	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Larsson H (1999)	2
NTRK1	1	PTPN11	20	affinity chromatography technology	Emdal KB (2015)	1
PLCG1	6	GAB2	3	pull down	Zhao C (1999)	1
SHC1	0	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boudot C (2002), Lynch DK (2002), van den Akker E (2004)	3
PARD3	5	MARK2	6	affinity chromatography technology	Yang Z (2012)	1
ARHGAP32	11	CRKL	1	pull down, affinity chromatography technology	Nakamura T (2002), Nakamura T (2002)	2
FGFR1	2	CRKL	1	affinity chromatography technology	Seo JH (2009)	1
NTRK1	1	ARHGAP32	11	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Nakamura T (2002), Nakamura T (2002), Nakamura T (2002), Emdal KB (2015)	4
NTRK1	1	C1QBP	0	affinity chromatography technology	Emdal KB (2015)	1
GAB1	3	C1QBP	0	affinity chromatography technology	Braun L (2000)	1
GAB1	3	SHC1	0	affinity chromatography technology, far western blotting, affinity chromatography technology	Ingham RJ (1998), Ingham RJ (1998), van den Akker E (2004)	3
DYNLT1	3	BAG3	4	pull down, biochemical	Gamerdinger M (2011), Gamerdinger M (2011)	2
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
CDH1	4	MARK2	6	bioid	Guo Z (2014)	1
FGFR1	2	CDH1	4	imaging technique	Chen TC (2014)	1
GAB1	3	FRS2	0	affinity chromatography technology	Zhou L (2015)	1
GRB2	2	ARHGAP32	11	two hybrid	Bandyopadhyay S (2010)	1
MET	7	CRK	0	affinity chromatography technology	Oh YM (2014)	1
CDH1	4	ERBB2	6	bioid	Guo Z (2014)	1
CRK	0	GAB2	3	affinity chromatography technology	Brehme M (2009)	1
EGLN3	0	GAB1	3	affinity chromatography technology	Rodriguez J (2016)	1
PARD3	5	GAB1	3	affinity chromatography technology, affinity chromatography technology	Yang Z (2012), Yang Z (2012)	2
GRB2	2	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2004), Lynch DK (2002), Zhao C (1999), Zhao C (1999), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Rolland T (2014), Huttlin EL (2017), Yu WM (2006), Yu WM (2006)	11
CDH1	4	C1QBP	0	affinity chromatography technology	Catimel B (2005)	1
CASP1	1	EGFR	5	enzymatic study	Bae SS (2001)	1
LGALS7	0	GAB1	3	affinity chromatography technology	Huttlin EL (2017)	1
GRAP2	0	GAB1	3	two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology	Qiu M (1998), Berry DM (2002), Huttlin EL (2015), Huttlin EL (2017)	4
GAB1	3	MST1R	4	affinity chromatography technology, two hybrid	van den Akker E (2004), van den Akker E (2004)	2
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
FGFR1	2	PIK3R1	6	imaging technique, two hybrid, pull down	Chen TC (2014), Hu Y (2004), Shi E (1993)	3
GAB2	3	FRS2	0	affinity chromatography technology	Zhou L (2015)	1
EGFR	5	GAB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, enzymatic study, affinity chromatography technology	Kameda H (2001), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Lehr S (1999), Mueller KL (2012)	6
FRS2	0	PTPN11	20	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology	Delahaye L (2000), Delahaye L (2000), Kurokawa K (2001), Hadari YR (1998), Hadari YR (1998), Liu BA (2012), Zhou L (2015)	7
ERBB2	6	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid	Schulze WX (2006), Wong L (1999), Olayioye MA (1998), Crovello CS (1998), Jones RB (2006), Yao Z (2017)	6
MST1R	4	PLCG1	6	affinity chromatography technology	Iwama A (1996)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
EGLN3	0	ARHGAP32	11	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	TUFM	1	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	TUFM	1	affinity chromatography technology	Rodriguez J (2016)	1
ERBB2	6	CRKL	1	unspecified method	Jones RB (2006)	1
ARL4C	0	GAB1	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM15	0	SHC1	0	protein complementation assay	Lee OH (2015)	1
GAB1	3	MARK2	6	affinity chromatography technology, affinity chromatography technology, pull down	Yang Z (2012), Yang Z (2012), Yang Z (2012)	3
BAG3	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
NTRK1	1	MARK2	6	affinity chromatography technology	Emdal KB (2015)	1
PRKCI	1	GAB1	3	affinity chromatography technology	Yang Z (2012)	1
GRB2	2	GAB1	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Oneyama C (2002), Lewitzky M (2001), Lewitzky M (2001), Lewitzky M (2001), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Bandyopadhyay S (2010), Ingham RJ (1998), Brehme M (2009), Fixman ED (1997), Bisson N (2011), Huttlin EL (2017), Kapoor GS (2010), Lehr S (1999)	15
ERBB2	6	PIK3R1	6	affinity chromatography technology, unspecified method	Crovello CS (1998), Jones RB (2006)	2
MET	7	GRB2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Ponzetto C (1996), Liang Q (1998), Goldoni S (2009), Hill KS (2011)	4
C1QBP	0	TUFM	1	affinity chromatography technology	Yagi M (2012)	1
CRK	0	FRS2	0	pull down	Meakin SO (1999)	1
ROCK1	6	GAB1	3	x-ray crystallography	Bourguignon LY (2003)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3