PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RGS4	0	GNAO1	21	pull down, pull down	Druey KM (1998), Sallese M (2000)	2
CPEB2	7	GABBR1	0	two hybrid	Chen PJ (2012)	1
RGS4	0	GABBR1	0	fluorescent resonance energy transfe	Fowler CE (2007)	1
KCNJ6	6	GABBR1	0	fluorescent resonance energy transfe	Fowler CE (2007)	1
GABBR1	0	DDIT3	1	affinity chromatography technology, imaging technique	Sauter K (2005), Sauter K (2005)	2
GABBR2	15	ATF4	2	affinity chromatography technology	White JH (2000)	1
ALB	1	GABBR1	0	affinity chromatography technology	Zhou M (2004)	1
GABBR1	0	ATF4	2	two hybrid, affinity chromatography technology	White JH (2000), White JH (2000)	2
MAX	0	GABBR1	0	pull down	Miyamoto-Sato E (2010)	1
GNAO1	21	GABBR1	0	fluorescent resonance energy transfe	Fowler CE (2007)	1
GABBR1	0	GABBR2	15	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	White JH (1998), White JH (1998), White JH (1998), Lahaie N (2016)	4
DDIT3	1	GABBR2	15	two hybrid, affinity chromatography technology, imaging technique	Sauter K (2005), Sauter K (2005), Sauter K (2005)	3
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
GABBR1	0	JAKMIP1	6	affinity chromatography technology, pull down	Couve A (2004), Couve A (2004)	2
GABBR1	0	USP14	1	affinity chromatography technology	Lahaie N (2016)	1
GABBR1	0	ATF5	4	two hybrid	White JH (2000)	1