PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VCP	6	HSP90B1	3	biochemical	Wan C (2015)	1
HSP90B1	3	GABRA1	6	pull down, affinity chromatography technology, affinity chromatography technology	Di XJ (2016), Di XJ (2016), Di XJ (2016)	3
GABRA1	6	PRKCD	2	affinity chromatography technology	Kumar S (2002)	1
OS9	4	VCP	6	affinity chromatography technology	Tyler RE (2012)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
OS9	4	HSP90B1	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Christianson JC (2008), Christianson JC (2008), Brockmeier U (2011), Tyler RE (2012), Christianson JC (2012), Dersh D (2014), Dersh D (2014), Dersh D (2014), Hein MY (2015)	9
PRKCD	2	VCP	6	pull down	Rex EB (2010)	1
GABRA1	6	VCP	6	affinity chromatography technology	Di XJ (2016)	1
GABRA1	6	CANX	4	affinity chromatography technology	Di XJ (2016)	1
GABRA1	6	SYVN1	2	affinity chromatography technology	Di XJ (2016)	1
UBQLN1	1	GABRA1	6	affinity chromatography technology, two hybrid	Bedford FK (2001), Bedford FK (2001)	2
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
CANX	4	HSP90B1	3	biochemical	Wan C (2015)	1
GABRA1	6	OS9	4	affinity chromatography technology	Di XJ (2016)	1
GABRA1	6	PRKCG	3	affinity chromatography technology	Kumar S (2002)	1
OS9	4	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2008), Tyler RE (2012), Tyler RE (2012), Iida Y (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Schulz J (2017)	8