PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
VCPIP1	4	SVIP	1	affinity chromatography technology	Sowa ME (2009)	1
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
SVIP	1	AMFR	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
DUSP22	1	SVIP	1	affinity chromatography technology, affinity chromatography technology	Li X (2016), Huttlin EL (2017)	2
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
SELENOS	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Schulze A (2005)	2
SELENOS	0	UFD1	1	affinity chromatography technology	Ye Y (2004)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
CPA5	1	SVIP	1	affinity chromatography technology	Huttlin EL (2017)	1
SVIP	1	SELENOS	0	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
DERL1	2	CANX	4	affinity chromatography technology	You H (2017)	1
DMC1	2	SVIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
SELENOS	0	NPLOC4	4	affinity chromatography technology	Ballar P (2007)	1
SLC16A14	0	SVIP	1	affinity chromatography technology	Huttlin EL (2017)	1
SVIP	1	CANX	4	biochemical	Ballar P (2007)	1
SELENOS	0	AMFR	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Zhong Y (2011)	2
SVIP	1	GOLGA1	0	biochemical	Ballar P (2007)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
SVIP	1	DERL1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
VCPIP1	4	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
VCPIP1	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SVIP	1	SYVN1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
SVIP	1	LAMP1	0	imaging technique	Wang Y (2011)	1
MGST3	0	SVIP	1	affinity chromatography technology	Huttlin EL (2017)	1
SVIP	1	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, unspecified method	Ballar P (2007), Ballar P (2007), Ballar P (2007), Wang Y (2011), Haenzelmann P (2011), Liu S (2013), Liu S (2013), Liu S (2013)	8
ATP6V1B1	4	TFRC	1	affinity chromatography technology	Nylandsted J (2011)	1
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
ATP6V1B1	4	SVIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6V1B1	4	LAMP1	0	affinity chromatography technology	Nylandsted J (2011)	1
SVIP	1	TFRC	1	biochemical	Ballar P (2007)	1
TMEM185A	0	SVIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
AMFR	2	CANX	4	affinity chromatography technology	Jo Y (2011)	1
SVIP	1	UFD1	1	biochemical	Ballar P (2007)	1
SELENOS	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ballar P (2007), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Zhong Y (2011), Christianson JC (2012)	7
SVIP	1	NPLOC4	4	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
GJB7	1	SVIP	1	affinity chromatography technology	Huttlin EL (2017)	1
CPA5	1	CANX	4	affinity chromatography technology	Huttlin EL (2017)	1
HOXB5	0	SVIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2