PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2G1	2	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
FBXL2	2	VCP	6	affinity chromatography technology	Kuchay S (2017)	1
FBXL2	2	UBE2D1	0	pull down	Han S (2015)	1
CDC34	3	CUL2	3	pull down	Sandoval D (2014)	1
YPEL1	0	FBXL2	2	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
CUL1	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Shima Y (2008), Reitsma JM (2017)	3
HSP90AA1	7	FOXM1	3	affinity chromatography technology	Taipale M (2012)	1
FBXL2	2	PIK3R2	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Kuchay S (2013), Kuchay S (2013), Kuchay S (2013)	3
FBXL2	2	APP	1	affinity chromatography technology, enzymatic study	Watanabe T (2012), Watanabe T (2012)	2
FBXL2	2	CDC34	3	pull down	Kuchay S (2013)	1
ITPR3	9	VCP	6	affinity chromatography technology	Kuchay S (2017)	1
FBXL2	2	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Li LQ (2016), Li LQ (2016)	2
YPEL3	0	FBXL2	2	affinity chromatography technology	Huttlin EL (2017)	1
FBXL2	2	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Ilyin GP (1999), Kuchay S (2013), Winston JT (1999), Li LQ (2016), Kuchay S (2017), Hauri S (2016)	7
FBXL2	2	UBE2G1	2	pull down	Han S (2015)	1
CUL2	3	UBE2D1	0	pull down, affinity chromatography technology, pull down	Sufan RI (2006), Sufan RI (2006), Maine GN (2007)	3
FBXL2	2	FBXO3	0	affinity chromatography technology	Krzysiak TC (2016)	1
HSP90AA1	7	FBXO3	0	affinity chromatography technology	Taipale M (2012)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FBXO3	0	SKP1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Yu H (2011), Cloutier P (2017), Hauri S (2016)	4
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
PIK3R2	3	APP	1	pull down	Olah J (2011)	1
VCP	6	PIK3R2	3	affinity chromatography technology	Yu CC (2013)	1
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
HSP90AA1	7	FBXL2	2	affinity chromatography technology	Taipale M (2012)	1
FBXL2	2	PIK3R1	6	affinity chromatography technology	Kuchay S (2013)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
FBXL2	2	AURKB	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Mallampalli RK (2013), Mallampalli RK (2013), Mallampalli RK (2013), Chen BB (2013), Chen BB (2013)	5
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
FBXL2	2	UBE2D3	1	pull down	Kuchay S (2013)	1
SKP1	0	UBE2D1	0	pull down, pull down	Kamura T (2000), Lin DI (2006)	2
FBXL2	2	NLRP3	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Han S (2015), Han S (2015), Han S (2015)	3
FBXL2	2	ITPR3	9	affinity chromatography technology, enzymatic study	Kuchay S (2017), Kuchay S (2017)	2
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
FBXL2	2	CCND2	2	affinity chromatography technology, enzymatic study	Chen BB (2012), Chen BB (2012)	2
FBXL2	2	CUL2	3	affinity chromatography technology	Kuchay S (2013)	1
CUL2	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
YPEL3	0	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
FBXL2	2	RABGGTB	1	affinity chromatography technology, affinity chromatography technology	Tan MK (2013), Tan MK (2013)	2
FBXL2	2	PTPN13	6	affinity chromatography technology	Kuchay S (2013)	1
AURKB	2	APP	1	pull down	Olah J (2011)	1
NLRP3	2	HSP90AA1	7	affinity chromatography technology	Mayor A (2007)	1
FBXL2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Li LQ (2016), Kuchay S (2017), Reitsma JM (2017)	4