PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	ABTB2	2	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CUL3	17	ABTB2	2	pull down, affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	3
COPS5	0	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
CUL3	17	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
EEF1A1	0	ABTB2	2	pull down, affinity chromatography technology, affinity chromatography technology	Koiwai K (2008), Koiwai K (2008), Koiwai K (2008)	3
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
TCTEX1D2	0	ABTB2	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	ABTB2	2	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	ABTB2	2	affinity chromatography technology	Kirli K (2015)	1
ABTB2	2	RBX1	2	affinity chromatography technology	Maezawa S (2008)	1
EEF1A1	0	RBX1	2	affinity chromatography technology	Morrissey C (2015)	1
CUL3	17	DNTT	1	affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008)	2
DNTT	1	ABTB2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	6
DUSP26	0	ABTB2	2	affinity chromatography technology	Li X (2016)	1
TRIM25	5	EEF1A1	0	biochemical	Wan C (2015)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
HS1BP3	0	ABTB2	2	affinity chromatography technology	Huttlin EL (2017)	1