PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BTRC	1	DPCD	0	bioid	Coyaud E (2015)	1
RABGGTA	1	DPCD	0	affinity chromatography technology	Huttlin EL (2017)	1
RUVBL2	4	APP	1	pull down	Olah J (2011)	1
RPAP3	1	DPCD	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RPAP3	1	WDR92	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cloutier P (2009), Itsuki Y (2008), Itsuki Y (2008), Taipale M (2014), Taipale M (2014), Wan C (2015), Cloutier P (2017), Cloutier P (2017)	8
BAG3	4	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
BAG3	4	DPCD	0	affinity chromatography technology	Chen Y (2013)	1
RPAP3	1	APP	1	pull down	Olah J (2011)	1
DPCD	0	APP	1	pull down	Olah J (2011)	1
PPP6R2	3	RUVBL2	4	bioid	Couzens AL (2013)	1
RPAP3	1	RUVBL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2009), Izumi N (2010), Taipale M (2014), Taipale M (2014), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	7
PPP6R2	3	WDR92	2	bioid	Couzens AL (2013)	1
PPP6R2	3	APP	1	pull down	Olah J (2011)	1
RUVBL2	4	DPCD	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Jeronimo C (2007), Rolland T (2014), Huttlin EL (2017), Cloutier P (2017)	6
WDR92	2	RUVBL1	2	affinity chromatography technology	Cloutier P (2017)	1
BTRC	1	OFD1	3	bioid	Coyaud E (2015)	1
RUVBL1	2	DPCD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jeronimo C (2007), Huttlin EL (2017), Cloutier P (2017)	4
WDR92	2	DPCD	0	affinity chromatography technology	Cloutier P (2017)	1
RUVBL1	2	RUVBL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ewing RM (2007), Jeronimo C (2007), Jeronimo C (2007), Puri T (2007), Rashid S (2009), Kim JH (2007), Kim JH (2007), McKeegan KS (2007), Lee JS (2010), Lee JS (2010), Cai Y (2007), Cai Y (2007), Ikura T (2000), Havugimana PC (2012), Venteicher AS (2008), Venteicher AS (2008), Bauer A (2000), Bauer A (2000), Bauer A (2000), Salzer U (1999), Izumi N (2010), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Jeganathan A (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	29
OFD1	3	WDR92	2	bioid	Gupta GD (2015)	1
RUVBL2	4	WDR92	2	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Cloutier P (2017)	2
RUVBL2	4	RPAP3	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Ni L (2009), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Cloutier P (2017), Cloutier P (2017)	7
OFD1	3	RPAP3	1	bioid	Gupta GD (2015)	1
OFD1	3	RUVBL1	2	affinity chromatography technology, pull down	Giorgio G (2007), Giorgio G (2007)	2
PPP6R2	3	DPCD	0	bioid	Couzens AL (2013)	1
OFD1	3	DPCD	0	bioid	Gupta GD (2015)	1