PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TERF2IP	1	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Ye JZ (2004), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
TERF2	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	OConnor MS (2004), OConnor MS (2004), OConnor MS (2004), Li B (2000), Zhu XD (2000), Zhu XD (2000), Chen Y (2011), Chen Y (2011), Chen Y (2011), Chen Y (2011), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2009), Havugimana PC (2012), Her YR (2013), Wan C (2015), Hein MY (2015), Her J (2015), Arat N Oe (2012), Li JS (2017), Jeong YY (2016), Ilic A (2017), Ilic A (2017)	28
TERF2	2	CALD1	2	affinity chromatography technology	Giannone RJ (2010)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
TINF2	1	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
TERF1	1	CALD1	2	two hybrid	Lee OH (2011)	1
TERF2IP	1	ACD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Hein MY (2015), Huttlin EL (2017)	3
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
TPP1	1	POT1	2	affinity chromatography technology, pull down	Zemp I (2014), Zemp I (2014)	2
ACD	1	TERF2	2	affinity chromatography technology	Liu D (2004)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
TERF1	1	TERF2IP	1	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015)	6
TERF2	2	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Giannone RJ (2010), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Hein MY (2015), Huttlin EL (2017)	7
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TINF2	1	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, far western blotting, imaging technique, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2013), Her YR (2013), Hein MY (2015), Huttlin EL (2017)	15
TPP1	1	TINF2	1	affinity chromatography technology, pull down	Zemp I (2014), Zemp I (2014)	2
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
TINF2	1	CALD1	2	two hybrid	Lee OH (2011)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
POT1	2	CALD1	2	affinity chromatography technology, two hybrid	Giannone RJ (2010), Lee OH (2011)	2