PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LYST	8	ZNF521	3	two hybrid	Tchernev VT (2002)	1
ZNF521	3	SMAD4	9	affinity chromatography technology	Bond HM (2004)	1
MTA1	3	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2003), Yao YL (2003), Yao YL (2003), Mazumdar A (2001), Mazumdar A (2001), Yoo YG (2006), Liu XF (2004), Khaleque MA (2008), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016)	21
HDAC1	4	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
ELAVL1	0	MTA1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
MTA1	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Huttlin EL (2015), Huttlin EL (2017), Millard CJ (2016), Hauri S (2016)	6
ZNF219	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang CL (2004), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD1	0	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
ZNF521	3	SMAD1	0	affinity chromatography technology	Bond HM (2004)	1
ZNF219	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF219	3	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	ZNF521	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
MBD3L1	0	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRAP	0	ZNF521	3	two hybrid	Fatima S (2015)	1
RBBP7	1	ZNF521	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	ZNF219	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang CL (2004), Huttlin EL (2015), Huttlin EL (2017)	3
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
ZNF219	3	MTA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD3L1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang CL (2004), Huttlin EL (2015), Huttlin EL (2017)	3