Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SPATS2L rs295114 C salbutamol efficacy yes This SNP was imputed rather than genotyped. This was assessed as a replication attempt for a previously reported association of a different SPATS2L SNP with response to bronchodilators. Bonferroni correction was performed according to the number of SNPs included that are within 50 kb up and downstream of SPATS2L. Allele C is not associated with response to salbutamol in children with Asthma as compared to allele T. 23992748 1183680176
SPATS2L rs295137 T salbutamol efficacy no These were two attempts to replicate the association (which did not reach significance) noted in the combined group from 6 clinical trials. Allele T is not associated with response to salbutamol in people with Asthma as compared to allele C. 22792082 978639678
SPATS2L rs295137 TT salbutamol efficacy no Median Bronchodilator response was 16.0 (inter-quartile range [6.2, 32.4]) for TT, 10.9(inter-quartile range [4.1,21.7]) for CC + CT. Association did not reach significance after Bonferroni correction, but authors followed up on the association and found siRNA knockdown evidence for this being a valid result. [stat_test:linear regression]. Genotype TT is associated with increased response to salbutamol in people with Asthma as compared to genotypes CC + CT. 22792082 978639673
SPATS2L rs295137 C salbutamol efficacy no GALAII genotyping was done using the Affymetrix LAT1 Array, which was designed to capture Latino population variation. This was assessed as a replication attempt for a previously reported association of a different SPATS2L SNP with response to bronchodilators. Bonferroni correction was performed according to the number of SNPs included that are within 50 kb up and downstream of SPATS2L. Allele C is not associated with response to salbutamol in children with Asthma as compared to allele T. 23992748 1183680170