PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LRIG1	1	ERBB3	3	affinity chromatography technology	Gur G (2004)	1
LRIG1	1	ERBB2	6	affinity chromatography technology	Gur G (2004)	1
LRIG1	1	TUBB8	2	affinity chromatography technology	Huttlin EL (2017)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
MET	7	ERBB3	3	affinity chromatography technology	Liu X (2011)	1
HLA-DRA	2	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP8	7	ERBB4	5	affinity chromatography technology	Meijer IM (2013)	1
LRIG1	1	CBL	7	pull down	Gur G (2004)	1
CNPY3	0	LRRC40	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCGB2A2	0	LRIG1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	USP8	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mizuno E (2005), Meijer IM (2013), Meijer IM (2013), Ali N (2013), Reincke M (2015), Reincke M (2015), Jeong CH (2015)	7
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
ERBB3	3	PON2	0	affinity chromatography technology	Li J (2013)	1
PTPRK	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HGS	5	LRIG1	1	affinity chromatography technology, imaging technique	Oh YM (2014), Oh YM (2014)	2
LRIG1	1	MTFR1L	0	affinity chromatography technology	Huttlin EL (2017)	1
SCARA3	2	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB3	3	HGS	5	affinity chromatography technology, affinity chromatography technology	Fosdahl AM (2017), Fosdahl AM (2017)	2
EGFR	5	CNPY3	0	affinity chromatography technology	Yao Z (2017)	1
CNPY3	0	LRIG1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	LRRC40	3	affinity chromatography technology	Tong J (2014)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
PON2	0	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CBL	7	ERBB2	6	pull down, affinity chromatography technology	Zhou P (2003), Bisaro B (2016)	2
CANT1	8	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRIG1	1	LRRC40	3	affinity chromatography technology	Huttlin EL (2017)	1
LRIG1	1	MET	7	affinity chromatography technology, affinity chromatography technology, imaging technique	Shattuck DL (2007), Oh YM (2014), Oh YM (2014)	3
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
PON2	0	LRIG2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPRK	1	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	PON2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2014), Huttlin EL (2015), Huttlin EL (2017)	3
LRIG1	1	ERBB4	5	affinity chromatography technology, affinity chromatography technology	Laederich MB (2004), Gur G (2004)	2
PTPRK	1	LRIG3	3	affinity chromatography technology	Huttlin EL (2015)	1
LRIG1	1	LRIG2	3	affinity chromatography technology	Huttlin EL (2017)	1
LRIG2	3	EGFR	5	affinity chromatography technology	Xiao Q (2014)	1
ERBB3	3	TUBB8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRIG1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Laederich MB (2004), Gur G (2004), Stutz MA (2008)	3
GAL3ST1	6	LRIG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB4	5	CBL	7	affinity chromatography technology	Kiuchi T (2014)	1
LRIG1	1	SCRIB	8	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
HGS	5	MET	7	affinity chromatography technology	Oh YM (2014)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
LRIG1	1	LRIG3	3	affinity chromatography technology	Huttlin EL (2017)	1
LRIG1	1	USP8	7	affinity chromatography technology	Oh YM (2014)	1
CBL	7	MET	7	enzymatic study, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, far western blotting, imaging technique	Petrelli A (2002), Ng C (2008), Ng C (2008), Kong-Beltran M (2006), Kong-Beltran M (2006), Peschard P (2004), Peschard P (2004), Deheuninck J (2009), Goldoni S (2009), Hill KS (2011), Sun Q (2011), Sun Q (2011), Sun Q (2011), Peschard P (2004), Chen TC (2014)	15
VCP	6	LRIG1	1	affinity chromatography technology	Yu CC (2013)	1
CNPY3	0	SCRIB	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRIG1	1	CNPY4	0	affinity chromatography technology	Huttlin EL (2017)	1
LRIG1	1	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
GAL3ST1	6	LRIG3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GML	0	LRIG1	1	affinity chromatography technology	Huttlin EL (2017)	1
HLA-E	3	LRIG1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3