PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
GATAD1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Varier RA (2016)	3
HDAC2	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
SNRPB	0	SNRPC	0	biochemical	Havugimana PC (2012)	1
DGCR6	0	SS18L1	2	two hybrid	Corominas R (2014)	1
SMARCA4	19	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Sif S (2001), Qiu Z (2008), Xu Z (2006), Pal S (2003), Battaglioli E (2002), Tando T (2010), Hang CT (2010), Shen JP (2017)	8
SNRPB	0	RFX6	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
NR1H3	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
SS18L1	2	RLIM	1	two hybrid	Ravasi T (2010)	1
SS18L1	2	TAF9B	0	two hybrid	Ravasi T (2010)	1
SMAD1	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
SS18L1	2	SS18L1	2	two hybrid	Rolland T (2014)	1
DPF3	2	SS18L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DPF3	2	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizaka A (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
SMAD3	1	SMARCC1	5	affinity chromatography technology	Xi Q (2008)	1
CUL3	17	BMI1	0	affinity chromatography technology	Hernandez-Munoz I (2005)	1
SMARCA4	19	SMARCC1	5	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sif S (2001), Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Inayoshi Y (2006), Inayoshi Y (2006), Pal S (2003), Pal S (2003), Bultman SJ (2005), Nagl NG (2005), Mahajan MC (2005), Trotter KW (2008), Dallas PB (1998), Tando T (2010), Tando T (2010), Bartlett C (2011), Bartlett C (2011), Oh J (2008), Oh J (2008), Havugimana PC (2012), Wan C (2015)	25
SMAD3	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
ATF3	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henderson A (2004), Xu YZ (2011), Xu YZ (2011)	3
SS18L1	2	PCGF6	0	two hybrid	Ravasi T (2010)	1
STAT3	0	SMAD1	0	affinity chromatography technology	Nakashima K (1999)	1
DPF2	3	SMARCD1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Tando T (2010), Tando T (2010), Mak AB (2010), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
SMARCE1	1	SMARCD1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
USP30	1	SS18L1	2	affinity chromatography technology	Sowa ME (2009)	1
SMAD3	1	HDAC4	10	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
SMARCC2	9	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Nagl NG (2005), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	10
SKA3	3	SS18L1	2	imaging technique	Chan YW (2012)	1
CUL3	17	SMARCC1	5	affinity chromatography technology	Bennett EJ (2010)	1
SMARCD1	5	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
NSD3	6	SMARCA4	19	affinity chromatography technology	Rahman S (2011)	1
CREBBP	29	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ito K (2000), Adenuga D (2010)	2
SMAD1	0	SMARCE1	1	two hybrid	Colland F (2004)	1
CUL3	17	DPF2	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SMARCC2	9	affinity chromatography technology	Bennett EJ (2010)	1
SMARCE1	1	DPF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kaeser MD (2008), Mak AB (2010), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
SNRPC	0	SS18L1	2	two hybrid	Rolland T (2014)	1
ATF3	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
SMARCD1	5	SS18L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCD1	5	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
SS18L1	2	AATF	0	two hybrid	Ravasi T (2010)	1
SS18L1	2	RFX6	3	two hybrid	Rual JF (2005)	1
ATF3	0	CREBBP	29	affinity chromatography technology, pull down	Kim HB (2010), Kim HB (2010)	2
ATF3	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kang Y (2003), Kang Y (2003), Yin X (2010), Yin X (2010)	4
CUL3	17	SNRPB	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SF3B4	2	affinity chromatography technology	Bennett EJ (2010)	1
SNRPB	0	SS18L1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SS18L1	2	SMARCA4	19	affinity chromatography technology, pull down	Qiu Z (2008), Qiu Z (2008)	2
DPF3	2	SMARCE1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AATF	0	SMAD3	1	two hybrid	Wang J (2011)	1
BMI1	0	CREBBP	29	affinity chromatography technology	Cao Q (2014)	1
STAT3	0	HDAC2	1	affinity chromatography technology, imaging technique	Yuan ZL (2005), Chen TC (2014)	2
BMI1	0	SS18L1	2	affinity chromatography technology	Cao Q (2014)	1
DPF3	2	SMARCC2	9	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
TCF7	1	SS18L1	2	two hybrid	Ravasi T (2010)	1
CUL3	17	SMARCA4	19	affinity chromatography technology	Bennett EJ (2010)	1
NSD3	6	SS18L1	2	affinity chromatography technology	Rahman S (2011)	1
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SS18L1	2	EP300	36	affinity chromatography technology	Aizawa H (2004)	1
DGCR6	0	MIA2	5	two hybrid	Corominas R (2014)	1
DPF3	2	SMARCA4	19	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizaka A (2012), Ishizaka A (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
BMI1	0	DPF2	3	affinity chromatography technology	Cao Q (2014)	1
ELF5	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
DPF2	3	SS18L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC4	10	SS18L1	2	two hybrid	Ravasi T (2010)	1
SS18L1	2	CREBBP	29	affinity chromatography technology, pull down	Aizawa H (2004), Aizawa H (2004)	2
SMARCC2	9	SS18L1	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	SMARCE1	1	affinity chromatography technology	Bennett EJ (2010)	1
BMI1	0	SMARCA4	19	affinity chromatography technology	Cao Q (2014)	1
MIA2	5	SS18L1	2	two hybrid	Rolland T (2014)	1
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
SMARCE1	1	SS18L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT3	0	ATF3	0	two hybrid	Grossmann A (2015)	1
BMI1	0	HDAC2	1	affinity chromatography technology, genetic interference	Abdouh M (2016), Wong AS (2016)	2
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
SMARCA4	19	DPF2	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Tando T (2010), Tando T (2010), Tando T (2010), Tando T (2010), Ishizaka A (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
SMAD3	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
SMARCA4	19	CREBBP	29	genetic interference	DiRenzo J (2000)	1
CUL3	17	SNRPC	0	affinity chromatography technology	Bennett EJ (2010)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
SMARCC2	9	DPF2	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Mak AB (2010), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
SMARCA4	19	STAT3	0	affinity chromatography technology, affinity chromatography technology, pull down	Giraud S (2004), Giraud S (2004), Giraud S (2004)	3
CUL3	17	SS18L1	2	affinity chromatography technology	Bennett EJ (2010)	1
FAM168A	0	SS18L1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CSTF2	2	SS18L1	2	two hybrid	Rolland T (2014)	1
DPF2	3	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Tando T (2010), Ishizaka A (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CREBBP	29	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Sun Y (2001)	2
SMARCD1	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Pal S (2003), Ito T (2008), Tando T (2010), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
DPF3	2	SMARCD1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ishizaka A (2012), Ishizaka A (2012), Huttlin EL (2015), Huttlin EL (2017)	4
SMARCC1	5	SS18L1	2	biochemical	Wan C (2015)	1
PCGF6	0	BMI1	0	two hybrid	Akasaka T (2002)	1
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
SMARCA4	19	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Zhao K (1998), Hu K (2006), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Battaglioli E (2002), ONeill DW (2000), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	18
SMAD3	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
STAT3	0	SS18L1	2	two hybrid	Ravasi T (2010)	1
HDAC4	10	ATF3	0	pull down	Darlyuk-Saadon I (2012)	1
DGCR6	0	RFX6	3	two hybrid	Corominas R (2014)	1
SS18L1	2	MED30	0	two hybrid	Ravasi T (2010)	1
LGALS3	0	SS18L1	2	two hybrid	Rolland T (2014)	1
CREBBP	29	STAT3	0	affinity chromatography technology, enzymatic study	Sun Y (2001), Yuan ZL (2005)	2
SS18L1	2	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
HDAC2	1	RLIM	1	affinity chromatography technology	Brandl A (2012)	1
SNRPC	0	FAM168A	0	two hybrid	Rolland T (2014)	1
SMARCE1	1	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Chen J (2005), Keppler BR (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	15
STAT3	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakashima K (1999), Nakashima K (1999), Ray S (2002), Ray S (2002), Yuan ZL (2005), Yuan ZL (2005), Gupta M (2011), Wang R (2005), Gray MJ (2005), Hou T (2008), Kotla S (2015)	11
SS18L1	2	GATAD1	0	two hybrid	Ravasi T (2010)	1
SMARCC2	9	HDAC2	1	affinity chromatography technology	Battaglioli E (2002)	1
BMI1	0	EP300	36	affinity chromatography technology	Cao Q (2014)	1
BRD1	5	SS18L1	2	two hybrid	Ravasi T (2010)	1
SNRPC	0	RFX6	3	two hybrid	Rolland T (2014)	1
SMARCA4	19	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Trotter KW (2008), Tando T (2010), Mak AB (2010), Nishimoto N (2012), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	15
SF3B4	2	SS18L1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PCGF6	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
BMI1	0	SMARCC1	5	affinity chromatography technology	Cao Q (2014)	1
NSD3	6	SMARCC1	5	affinity chromatography technology	Rahman S (2011)	1
NR1H3	1	HDAC4	10	affinity chromatography technology	Lee JH (2016)	1
SMARCE1	1	HDAC2	1	affinity chromatography technology	Battaglioli E (2002)	1
SS18L1	2	ANKRD22	1	two hybrid	Ravasi T (2010)	1