PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CNTNAP2	5	CTR9	10	two hybrid	Nakayama M (2002)	1
CNTNAP2	5	MEOX2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
CNTN2	4	CNTNAP2	5	affinity chromatography technology, affinity chromatography technology	Traka M (2003), Traka M (2003)	2
CNTNAP2	5	EPB41L3	5	pull down	Denisenko-Nehrbass N (2003)	1
IQCB1	3	CNTNAP2	5	affinity chromatography technology	Sang L (2011)	1
CNTNAP2	5	CASK	18	pull down	Spiegel I (2002)	1
CNTNAP2	5	MACF1	12	two hybrid	Nakayama M (2002)	1
CNTNAP2	5	ZMIZ1	7	two hybrid	Nakayama M (2002)	1