PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LNX1	7	PPFIA3	5	affinity chromatography technology	Lenihan JA (2017)	1
PPFIA2	8	GIT1	10	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
IQCB1	3	ERC2	7	affinity chromatography technology	Sang L (2011)	1
BSN	9	RIMS1	6	affinity chromatography technology	Takao-Rikitsu E (2004)	1
LNX1	7	ERC1	0	affinity chromatography technology	Lenihan JA (2017)	1
ERC2	7	BSN	9	affinity chromatography technology, affinity chromatography technology	Takao-Rikitsu E (2004), Takao-Rikitsu E (2004)	2
GIT1	10	PCLO	9	two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Kim S (2003), Kim S (2003), Kim S (2003), Kim S (2003), Kim S (2003)	5
PPFIA3	5	GIT1	10	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
PPFIA3	5	ERC2	7	two hybrid, pull down	Ko J (2003), Ko J (2003)	2
PPFIA1	5	GRIP2	5	affinity chromatography technology, affinity chromatography technology	Ko J (2003), Ko J (2003)	2
BSN	9	UNC13A	10	affinity chromatography technology	Takao-Rikitsu E (2004)	1
GRIP2	5	GIT1	10	affinity chromatography technology	Ko J (2003)	1
LNX1	7	ERC2	7	affinity chromatography technology, imaging technique	Lenihan JA (2017), Lenihan JA (2017)	2
ERC2	7	PCLO	9	affinity chromatography technology	Takao-Rikitsu E (2004)	1
DGUOK	1	ERC2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERC2	7	PPFIA4	1	two hybrid, two hybrid, pull down	Ko J (2003), Ko J (2003), Ko J (2003)	3
MYB	3	ERC2	7	pull down	Miyamoto-Sato E (2010)	1
ERC2	7	LSP1	3	affinity chromatography technology	Harrison RE (2004)	1
PPFIA2	8	ERC2	7	two hybrid, pull down, affinity chromatography technology	Ko J (2003), Ko J (2003), Ko J (2003)	3
PPFIA4	1	GIT1	10	two hybrid, pull down, two hybrid, two hybrid	Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003)	4
PPFIA1	5	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
PPFIA1	5	PPFIA2	8	pull down, pull down	Serra-Pages C (1998), Serra-Pages C (1998)	2
PPFIA1	5	GIT1	10	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003)	7
ERC2	7	RIMS1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down	Takao-Rikitsu E (2004), Ohtsuka T (2002), Ohtsuka T (2002), Ohtsuka T (2002), Ohtsuka T (2002), Ohtsuka T (2002)	6
PPFIA1	5	ERC2	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Ko J (2003), Ko J (2003), Ko J (2003), Ko J (2003)	4
LNX1	7	PPFIA1	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Lenihan JA (2017), Lenihan JA (2017), Lenihan JA (2017)	3
PPFIA2	8	PPFIA3	5	two hybrid	Serra-Pages C (1998)	1
ERC2	7	ERC1	0	biochemical	Havugimana PC (2012)	1
ERC2	7	GRIP2	5	affinity chromatography technology	Ko J (2003)	1
ERC2	7	GIT1	10	affinity chromatography technology	Ko J (2003)	1
ERC2	7	UNC13A	10	affinity chromatography technology	Takao-Rikitsu E (2004)	1