PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC5	4	MTA2	1	affinity chromatography technology	Greco TM (2011)	1
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
VCP	6	RUVBL2	4	affinity chromatography technology	Fogeron ML (2013)	1
RTCB	1	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
EGFR	5	APPL1	1	unspecified method	Jones RB (2006)	1
PIK3R2	3	PIK3CA	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Kuchay S (2013), Hein MY (2015)	3
NTRK1	1	TUBB3	3	affinity chromatography technology	Emdal KB (2015)	1
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
NTRK1	1	APPL2	4	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	MTA2	1	affinity chromatography technology, pull down	Banach-Orlowska M (2009), Miaczynska M (2004)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TGFBR1	2	PIK3R1	6	affinity chromatography technology	Krymskaya VP (1997)	1
HDAC1	4	PIK3CA	8	affinity chromatography technology	Hein MY (2015)	1
OCRL	1	CLTA	1	affinity chromatography technology	Boldt K (2016)	1
EGFR	5	AKT2	1	affinity chromatography technology	Tong J (2014)	1
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
HDAC5	4	APPL1	1	affinity chromatography technology	Joshi P (2013)	1
ELAVL1	0	APPL1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
EGFR	5	PRKCZ	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
C16orf70	4	OCRL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLUH	8	APPL1	1	biochemical	Kristensen AR (2012)	1
RBBP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Hakimi MA (2003), Zhang Y (2002), Tong JK (1998), Sun JM (2007), Sun JM (2007), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Wan C (2015), Hauri S (2016)	14
RBBP4	3	VCP	6	biochemical	Havugimana PC (2012)	1
NTRK1	1	DPYSL5	4	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	APPL2	4	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Nechamen CA (2007), Nechamen CA (2007), Rolland T (2014), Huttlin EL (2017)	5
NTRK1	1	PIK3R2	3	affinity chromatography technology	Emdal KB (2015)	1
VCP	6	KIAA1468	5	affinity chromatography technology	Yu CC (2013)	1
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
NTRK1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takahashi Y (2011), Emdal KB (2015), Emdal KB (2015)	3
APPL1	1	RTCB	1	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
NTRK1	1	OCRL	1	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
HDAC5	4	VCP	6	affinity chromatography technology	Greco TM (2011)	1
HDAC3	5	AKT1	1	affinity chromatography technology	Zampetaki A (2010)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
APPL1	1	PIK3R2	3	two hybrid	Grossmann A (2015)	1
TP53	0	CLTA	1	affinity chromatography technology	Horikawa I (2014)	1
APPL1	1	TTC4	1	biochemical	Kristensen AR (2012)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
APPL1	1	KIAA1468	5	biochemical	Kristensen AR (2012)	1
RUVBL2	4	APPL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Rashid S (2009), Rashid S (2009), Rashid S (2009)	3
APPL2	4	RBBP7	1	pull down	Miaczynska M (2004)	1
DOK2	2	DOK3	5	two hybrid	Grossmann A (2015)	1
APPL1	1	APPL1	1	x-ray crystallography, pull down, two hybrid	Zhu G (2007), Zhu G (2007), Rolland T (2014)	3
PRKCZ	5	AKT2	1	affinity chromatography technology, affinity chromatography technology	Wang J (2008), Wang J (2008)	2
APPL1	1	TRAF6	0	affinity chromatography technology	Cheng KK (2013)	1
VCP	6	TTC4	1	affinity chromatography technology	Yu CC (2013)	1
ELAVL1	0	RAB5A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	SOCS6	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
APPL1	1	TP53	0	two hybrid	Grossmann A (2015)	1
APPL1	1	KXD1	1	two hybrid	Wang J (2011)	1
ADIPOR2	3	APPL1	1	affinity chromatography technology, two hybrid	Mao X (2006), Mao X (2006)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	OCRL	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
APPL1	1	KLF15	1	two hybrid	Grossmann A (2015)	1
TRAF2	1	APPL1	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
TRAF6	0	UBE2O	5	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
EIF3CL	0	CLTA	1	affinity chromatography technology	Boldt K (2016)	1
KLHL2	0	APPL1	1	affinity chromatography technology	Huttlin EL (2017)	1
SOCS6	0	PIK3R1	6	affinity chromatography technology	Krebs DL (2002)	1
EGFR	5	RUVBL2	4	affinity chromatography technology	Yao Z (2017)	1
APPL1	1	HDAC3	5	affinity chromatography technology	Joshi P (2013)	1
RAB21	0	APPL1	1	pull down	Zhu G (2007)	1
APPL1	1	DOK3	5	two hybrid	Grossmann A (2015)	1
NTRK1	1	RTCB	1	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	ZNF830	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
HDAC3	5	PIK3R1	6	affinity chromatography technology	Alam S (2011)	1
CLTA	1	VCP	6	affinity chromatography technology	Pleasure IT (1993)	1
APPL1	1	BRWD1	6	two hybrid	Grossmann A (2015)	1
APPL1	1	ID1	0	two hybrid	Grossmann A (2015)	1
OCRL	1	CLTB	0	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	RUVBL2	4	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	PIK3R1	6	affinity chromatography technology, two hybrid	Yang L (2003), Grossmann A (2015)	2
APPL1	1	BATF3	0	two hybrid	Grossmann A (2015)	1
EIF3CL	0	APPL1	1	affinity chromatography technology	Boldt K (2016)	1
APPL1	1	SOCS6	0	two hybrid	Grossmann A (2015)	1
APPL1	1	MAGEC3	1	two hybrid	Grossmann A (2015)	1
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
APPL1	1	UBE2O	5	two hybrid	Rolland T (2014)	1
TGFBR1	2	PIK3R2	3	affinity chromatography technology	Krymskaya VP (1997)	1
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
HDAC5	4	RUVBL2	4	affinity chromatography technology	Greco TM (2011)	1
RUVBL2	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JH (2006), Rashid S (2009), Lee JS (2010), Lee JS (2010), Lee JS (2010)	5
APPL1	1	CMTM4	0	two hybrid	Wang J (2011)	1
TMEM17	0	ADIPOR1	2	bioid	Gupta GD (2015)	1
DOK2	2	EGFR	5	pull down	Jones N (1999)	1
NTRK1	1	APPL1	1	affinity chromatography technology	Emdal KB (2015)	1
FARS2	3	APPL1	1	two hybrid	Rolland T (2014)	1
HDAC5	4	TP53	0	affinity chromatography technology	Greco TM (2011)	1
RHEBL1	1	TRAF2	1	affinity chromatography technology	Pilot-Storck F (2010)	1
OCRL	1	RAB5A	0	pull down	Hyvola N (2006)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
VCP	6	PIK3R2	3	affinity chromatography technology	Yu CC (2013)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
APPL1	1	SH2D2A	2	two hybrid	Grossmann A (2015)	1
NTRK1	1	CLTA	1	affinity chromatography technology	Emdal KB (2015)	1
AR	3	HDAC3	5	pull down, affinity chromatography technology	Franco PJ (2003), Zhu P (2006)	2
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
DCC	3	AR	3	affinity chromatography technology, pull down, two hybrid	Wafa LA (2003), Wafa LA (2003), Wafa LA (2003)	3
NTRK1	1	PIK3R1	6	affinity chromatography technology	Emdal KB (2015)	1
RBBP4	3	HDAC3	5	pull down, pull down	Nicolas E (2001), Nicolas E (2001)	2
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
ELAVL1	0	MTA2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RAB5A	0	APPL2	4	pull down	Miaczynska M (2004)	1
CBLB	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavagna-Sevenier C (1998), Elly C (1999), Elly C (1999), Alcazar I (2009), Fang D (2001)	5
APPL1	1	ADIPOR1	2	two hybrid, pull down, affinity chromatography technology, two hybrid, protein complementation assay	Mao X (2006), Mao X (2006), Mao X (2006), Mao X (2006), Aouida M (2013)	5
APPL1	1	HDAC2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Banach-Orlowska M (2009), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Joshi P (2013)	4
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
TMEM17	0	OCRL	1	bioid	Gupta GD (2015)	1
TRAF6	0	PRKCZ	5	affinity chromatography technology	Sanz L (2000)	1
CBLB	3	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
MAGEA9	0	APPL1	1	two hybrid	Rolland T (2014)	1
APPL1	1	DOK2	2	two hybrid	Grossmann A (2015)	1
ELAVL1	0	ADIPOR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TUBB3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CLTB	0	CLTA	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
APPL1	1	AR	3	affinity chromatography technology	Yang L (2003)	1
APPL1	1	CBL	7	two hybrid	Grossmann A (2015)	1
CLTB	0	APPL1	1	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
RUVBL2	4	HDAC2	1	affinity chromatography technology	Rashid S (2009)	1
CBLB	3	PIK3R2	3	affinity chromatography technology	Alcazar I (2009)	1
EGFR	5	SH2D2A	2	unspecified method	Jones RB (2006)	1
VCP	6	APPL1	1	affinity chromatography technology	Yu CC (2013)	1
APPL1	1	RBBP7	1	affinity chromatography technology, pull down	Banach-Orlowska M (2009), Miaczynska M (2004)	2
TRAF2	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
RAB5A	0	APPL1	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Miaczynska M (2004), Miaczynska M (2004), Mao X (2006), Zhu G (2007)	4
MEOX1	0	APPL1	1	two hybrid	Rolland T (2014)	1
GIPC2	2	APPL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APPL2	4	MTA2	1	pull down	Miaczynska M (2004)	1
SOCS6	0	PIK3R2	3	affinity chromatography technology	Krebs DL (2002)	1
TPCN2	0	APPL1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
NTRK1	1	TRAF6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Jadhav T (2008), Geetha T (2005), Zheng C (2015)	3
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
APPL1	1	CBLB	3	two hybrid	Grossmann A (2015)	1
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
APPL1	1	SCAPER	5	two hybrid	Grossmann A (2015)	1
SH2D2A	2	PIK3R1	6	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TMEM17	0	APPL1	1	bioid	Gupta GD (2015)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
APPL1	1	PRKCZ	5	imaging technique, affinity chromatography technology	Song J (2016), Song J (2016)	2
EIF3CL	0	CLTB	0	affinity chromatography technology	Boldt K (2016)	1
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
APPL1	1	AKT1	1	affinity chromatography technology, two hybrid, imaging technique	Yang L (2003), Grossmann A (2015), Chen TC (2014)	3
FSHR	2	APPL2	4	affinity chromatography technology	Nechamen CA (2007)	1
TRAF6	0	PLEKHF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
OCRL	1	EIF3CL	0	affinity chromatography technology	Boldt K (2016)	1
ELAVL1	0	TGFBR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	MTA2	1	pull down, affinity chromatography technology, pull down	Yao YL (2003), Luo J (2000), Luo J (2000)	3
NTRK1	1	UBE2O	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CLUH	8	affinity chromatography technology	Emdal KB (2015)	1
C16orf70	4	APPL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RUVBL2	4	INO80E	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cai Y (2007), Cai Y (2007), Yao T (2008), Huttlin EL (2017)	5
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
VCP	6	TUBB3	3	biochemical	Wan C (2015)	1
HDAC5	4	HDAC1	4	affinity chromatography technology	Greco TM (2011)	1
ELAVL1	0	RAB21	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
TMEM17	0	AKT2	1	bioid	Gupta GD (2015)	1
TPCN2	0	OCRL	1	affinity chromatography technology	Huttlin EL (2017)	1
MTA2	1	RBBP7	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Feng Q (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	11
NTRK1	1	MTA2	1	affinity chromatography technology	Emdal KB (2015)	1
TGFBR1	2	APPL1	1	affinity chromatography technology, pull down, imaging technique	Song J (2016), Song J (2016), Song J (2016)	3
MAP3K1	4	APPL1	1	enzymatic study	Charlaftis N (2014)	1
EGFR	5	CBLB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Schulze WX (2006), Ettenberg SA (1999), Davies GC (2006), Davies GC (2006), Tong J (2009), Ettenberg SA (2001), Tong J (2008), Levkowitz G (1999), Tong J (2014)	9
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
SH2D2A	2	VCP	6	affinity chromatography technology, affinity chromatography technology, far western blotting	Marti F (2005), Marti F (2005), Marti F (2005)	3
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
KIAA1468	5	TTC4	1	biochemical	Kristensen AR (2012)	1
FAM167A	1	APPL1	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Adenuga D (2010), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016)	9
NTRK1	1	PIK3CA	8	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	RBBP4	3	affinity chromatography technology	Fogeron ML (2013)	1
OCRL	1	APPL1	1	affinity chromatography technology	Boldt K (2016)	1
HDAC5	4	RBBP4	3	affinity chromatography technology	Greco TM (2011)	1
RUVBL2	4	APPL2	4	affinity chromatography technology, affinity chromatography technology, pull down	Rashid S (2009), Rashid S (2009), Rashid S (2009)	3
APPL1	1	INO80E	0	two hybrid	Grossmann A (2015)	1
APPL1	1	TUBB3	3	affinity chromatography technology	Song J (2016)	1
APPL1	1	HDAC1	4	affinity chromatography technology, pull down, imaging technique	Banach-Orlowska M (2009), Banach-Orlowska M (2009), Chen TC (2014)	3
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
APPL1	1	RHEBL1	1	two hybrid	Rolland T (2014)	1
RTCB	1	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
RAB5A	0	PIK3R1	6	affinity chromatography technology	Chamberlain MD (2004)	1
FSHR	2	APPL1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Cohen BD (2004), Nechamen CA (2004), Nechamen CA (2004), Nechamen CA (2004)	4
VCP	6	AR	3	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
APPL1	1	RBBP4	3	affinity chromatography technology	Banach-Orlowska M (2009)	1
MTA2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Zhang Y (1999), Banach-Orlowska M (2009), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	14
EGFR	5	CLTA	1	affinity chromatography technology, affinity chromatography technology	Wu SL (2006), Wu SL (2006)	2
HDAC5	4	RBBP7	1	affinity chromatography technology	Greco TM (2011)	1
APPL1	1	DPYSL5	4	two hybrid	Wang J (2011)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRAF6	0	CBLB	3	affinity chromatography technology	Qiao G (2007)	1
MTA2	1	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Banach-Orlowska M (2009), Pflum MK (2001), Feng Q (2001), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Wan C (2015), Brasen C (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	13
TRAF6	0	ID1	0	affinity chromatography technology	Li X (2017)	1
AKT2	1	UBE2O	5	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
PIK3CA	8	EGFR	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
EGFR	5	TUBB3	3	affinity chromatography technology	Foerster S (2013)	1
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
TMEM17	0	PIK3R1	6	bioid	Gupta GD (2015)	1
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
APPL1	1	DOK7	2	two hybrid	Grossmann A (2015)	1
APPL2	4	DOK3	5	two hybrid	Grossmann A (2015)	1
TP53	0	RBBP7	1	affinity chromatography technology	Fogeron ML (2013)	1
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
TP53	0	CLTB	0	affinity chromatography technology	Horikawa I (2014)	1
ELAVL1	0	PLEKHF2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	RBBP4	3	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	PIK3CA	8	imaging technique	Chen TC (2014)	1
DCC	3	APPL1	1	two hybrid, affinity chromatography technology	Liu J (2002), Liu J (2002)	2
APPL1	1	ZNF829	0	two hybrid	Grossmann A (2015)	1
FSHR	2	AKT2	1	affinity chromatography technology	Nechamen CA (2004)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
PLEKHF2	1	APPL1	1	two hybrid	Venkatesan K (2009)	1
PRKCZ	5	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Doornbos RP (1999), Wang J (2008), Wang J (2008), Joshi J (2008), Joshi J (2008)	5
CLTA	1	APPL1	1	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	HDAC2	1	affinity chromatography technology	Emdal KB (2015)	1
AKT2	1	APPL1	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Mitsuuchi Y (1999), Mitsuuchi Y (1999), Mitsuuchi Y (1999), Nechamen CA (2007)	4
NTRK1	1	CBLB	3	affinity chromatography technology, affinity chromatography technology	Emdal KB (2015), Emdal KB (2015)	2