PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
PSMC3	0	KDM1A	2	two hybrid	Rolland T (2014)	1
LCOR	4	PHF1	1	affinity chromatography technology	Hauri S (2016)	1
KDM1A	2	RBBP7	1	affinity chromatography technology	Li Q (2011)	1
RBBP7	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
HIC1	1	EED	1	affinity chromatography technology	Boulay G (2012)	1
LCOR	4	EZH1	1	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	HIST1H3A	3	enzymatic study, enzymatic study, affinity chromatography technology	Martin C (2006), Cha TL (2005), Cha TL (2005)	3
PHF19	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballare C (2012), Hauri S (2016), Hauri S (2016)	3
PHF19	3	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
PHF1	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Cai L (2013), Hauri S (2016)	2
TEX10	3	SENP3	1	biochemical	Wan C (2015)	1
SUZ12	0	EPOP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	3
HIC1	1	RBBP4	3	affinity chromatography technology	Van Rechem C (2010)	1
PHF19	3	HRAS	2	affinity chromatography technology	Huttlin EL (2015)	1
HIC1	1	EZH2	4	affinity chromatography technology	Boulay G (2012)	1
EED	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
HIST1H3A	3	26148	0	bioid	Lambert JP (2015)	1
RBBP4	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
SENP3	1	PELP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Kashiwaya K (2010), Kashiwaya K (2010), Castle CD (2012), Castle CD (2012), Wan C (2015)	5
HIC1	1	PHF19	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Boulay G (2012), Boulay G (2012), Boulay G (2012)	3
EPOP	0	EZH1	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
PELP1	3	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Choi YB (2004), Choi YB (2004), Choi YB (2004), Nair SS (2010), Nair SS (2010), Kashiwaya K (2010)	6
PHF19	3	PELP1	3	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H1	0	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study	Carbone R (2006), Kamoi K (2006), Mal AK (2006)	3
PHF19	3	EZH1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	3
HIST1H3A	3	EED	1	far western blotting	Tie F (2007)	1
EPOP	0	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
SUZ12	0	LCOR	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
EZH2	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
PHF19	3	GTF2F1	0	affinity chromatography technology	Huttlin EL (2017)	1
PHF1	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong Z (2008), Sarma K (2008), Hauri S (2016)	3
EPOP	0	PCBP1	2	affinity chromatography technology	Hauri S (2016)	1
EED	1	EPOP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016), Hauri S (2016)	3
SRC	2	PELP1	3	affinity chromatography technology, pull down	Unni E (2004), Barletta F (2004)	2
PHF1	1	EZH2	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell S (2001), Hong Z (2008), Sarma K (2008), Cao Q (2014), Cai L (2013), Cai L (2013), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
SUZ12	0	PHF19	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Ballare C (2012), Ballare C (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
PHF1	1	HIST1H3A	3	pull down	Horton JR (2010)	1
EPOP	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
PHF19	3	RAP2A	0	affinity chromatography technology	Huttlin EL (2015)	1
EED	1	PCBP1	2	affinity chromatography technology	Cao Q (2014)	1
PHF19	3	DCTN3	2	affinity chromatography technology	Huttlin EL (2015)	1
EZH1	1	RBBP7	1	affinity chromatography technology	Hauri S (2016)	1
HIST1H3A	3	RBBP7	1	affinity chromatography technology	Foltz DR (2009)	1
KDM1A	2	HIST1H3A	3	enzymatic study, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Chen Y (2006), Forneris F (2005), Shi YJ (2005), Lee MG (2005), Metzger E (2010), Lin Y (2010)	6
PHF1	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarma K (2008), Cai L (2013), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
26148	0	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Hauri S (2016)	3
SUZ12	0	PDLIM5	0	affinity chromatography technology	Cao Q (2014)	1
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
LCOR	4	EZH2	4	affinity chromatography technology	Hauri S (2016)	1
EZH1	1	26148	0	affinity chromatography technology	Hauri S (2016)	1
PSMC3	0	GTF2F1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHF19	3	RCN2	0	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	KDM1A	2	two hybrid	Weimann M (2013)	1
PHF19	3	NRBP2	2	affinity chromatography technology	Huttlin EL (2017)	1
PHF19	3	SENP3	1	affinity chromatography technology	Huttlin EL (2017)	1
PHF19	3	QRICH1	8	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	PROCR	0	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	CHAMP1	8	affinity chromatography technology	Huttlin EL (2017)	1
LCOR	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	PHF19	3	affinity chromatography technology	Boulay G (2011)	1
SUZ12	0	26148	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2017), Hauri S (2016)	3
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
LCOR	4	PHF19	3	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
PHF1	1	EZH1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai L (2013), Hauri S (2016), Hauri S (2016)	3
PHF19	3	PHF1	1	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
LCOR	4	EED	1	affinity chromatography technology	Hauri S (2016)	1
EED	1	KDM1A	2	affinity chromatography technology	Cao Q (2014)	1
EZH1	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008)	3
EPOP	0	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
PHF1	1	26148	0	affinity chromatography technology	Hauri S (2016)	1
EZH1	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Jones CA (1998), van Lohuizen M (1998), Wang X (2017), Hauri S (2016), Hauri S (2016)	8
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
PHF19	3	GNA13	0	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	MALSU1	2	affinity chromatography technology	Huttlin EL (2017)	1
PHF19	3	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boulay G (2011), Cao Q (2014), Ballare C (2012), Ballare C (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
SENP3	1	HIC1	1	enzymatic study	Stankovic-Valentin N (2007)	1
SUV39H1	0	RBBP4	3	pull down	Vaute O (2002)	1
HIC1	1	PHF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Boulay G (2012), Boulay G (2012), Boulay G (2012)	3
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
HIC1	1	SUZ12	0	affinity chromatography technology	Boulay G (2012)	1
PSMC3	0	PHF19	3	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
LCOR	4	RBBP7	1	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	EPOP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016), Hauri S (2016)	3
PELP1	3	TEX10	3	affinity chromatography technology, biochemical, biochemical	Castle CD (2012), Castle CD (2012), Wan C (2015)	3
LCOR	4	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	PCBP1	2	affinity chromatography technology	Hauri S (2016)	1
EZH2	4	26148	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Hein MY (2015), Hauri S (2016)	3
PHF19	3	TEX10	3	affinity chromatography technology	Huttlin EL (2017)	1
GSTCD	1	SUV39H2	3	two hybrid	Weimann M (2013)	1
PHF19	3	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
PHF19	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
PHF19	3	TUFM	1	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	RBM5	0	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballare C (2012), Hauri S (2016), Hauri S (2016)	3
EPOP	0	PHF1	1	affinity chromatography technology	Hauri S (2016)	1
RBBP7	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
KDM1A	2	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), Cui S (2011), Cui S (2011)	3
PHF19	3	PDLIM5	0	affinity chromatography technology	Huttlin EL (2017)	1
SUZ12	0	TUFM	1	affinity chromatography technology	Cao Q (2014)	1
TUBA1C	1	RCN2	0	affinity chromatography technology	Hein MY (2015)	1
PHF19	3	GSTCD	1	affinity chromatography technology	Huttlin EL (2017)	1
PHF19	3	SRC	2	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boulay G (2011), Ballare C (2012), Ballare C (2012), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
SUZ12	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
KDM1A	2	PELP1	3	affinity chromatography technology, pull down, imaging technique, imaging technique	Nair SS (2010), Nair SS (2010), Nair SS (2010), Nair SS (2010)	4
SUV39H1	0	RBBP7	1	pull down	Vaute O (2002)	1
EZH1	1	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
ACTBL2	0	DCTN3	2	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
PHF1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong Z (2008), Sarma K (2008), Cao Q (2014), Cai L (2013), Cai L (2013), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
PHF19	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
SUV39H2	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	26148	0	affinity chromatography technology	Hauri S (2016)	1
HIST1H3A	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Wysocka J (2006), Nishioka K (2002), Tagami H (2004), Foltz DR (2009), Millard CJ (2016)	5
PHF19	3	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
EPOP	0	PHF19	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
PHF19	3	RANGRF	2	affinity chromatography technology	Huttlin EL (2015)	1
PHF19	3	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
EZH1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
PHF19	3	HIST1H3A	3	x-ray crystallography, unspecified method	Ballare C (2012), Ballare C (2012)	2
SUZ12	0	RBM5	0	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2017)	2
GSTCD	1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2