PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SP1	0	TAL1	0	pull down, two hybrid, affinity chromatography technology	Lecuyer E (2002), Lecuyer E (2002), Lecuyer E (2002)	3
GATA3	2	FBXW7	2	pull down, affinity chromatography technology	Kitagawa K (2014), Kitagawa K (2014)	2
SP1	0	LMO2	2	pull down	Lecuyer E (2002)	1
MAPK14	0	HDAC3	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	3
REPIN1	3	GATA3	2	pull down	Hong SJ (2008)	1
GATA3	2	WEE1	2	genetic interference	Shen JP (2017)	1
HDAC3	5	SPI1	1	affinity chromatography technology	Ueki N (2008)	1
TBX21	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
SP1	0	GATA3	2	affinity chromatography technology, pull down	Hong SJ (2008), Hong SJ (2008)	2
HDAC3	5	SP1	0	affinity chromatography technology	Huang W (2006)	1
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
FOXA1	2	GATA3	2	affinity chromatography technology	Jozwik KM (2016)	1
GATA3	2	MDM2	2	affinity chromatography technology	Yamashita M (2005)	1
PSMA3	1	TCF7L2	12	two hybrid	Wang J (2011)	1
GATA3	2	PSMA3	1	two hybrid	Rolland T (2014)	1
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
MAPK14	0	BMI1	0	enzymatic study	Srivastav RK (2011)	1
USP21	2	GATA3	2	affinity chromatography technology, affinity chromatography technology	Zhang J (2013), Zhang J (2013)	2
GATA3	2	HDAC4	10	affinity chromatography technology	Han S (2006)	1
HDAC4	10	FOXP3	1	imaging technique	Liu R (2009)	1
GATA3	2	LMO1	0	affinity chromatography technology, pull down	Ono Y (1998), Ono Y (1997)	2
MAPK14	0	GATA3	2	enzymatic study	Kitagawa K (2014)	1
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
LMO1	0	TAL1	0	pull down, affinity chromatography technology, two hybrid	Valge-Archer VE (1994), Valge-Archer VE (1994), Wadman I (1994)	3
GATA3	2	MYB	3	affinity chromatography technology	Kozuka T (2011)	1
SPI1	1	GATA3	2	pull down	Rekhtman N (1999)	1
CDK2	0	GATA3	2	enzymatic study	Kitagawa K (2014)	1
FBXW7	2	CDK2	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2012), Zhang W (2012)	2
TAL1	0	LMO2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid	Wadman I (1994), Valge-Archer VE (1994), Goardon N (2006), Osada H (1995), Osada H (1995), Osada H (1995), Osada H (1995), Wadman I (1994), Wadman I (1994), Wadman I (1994)	10
MYB	3	FBXW7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kanei-Ishii C (2008), Kanei-Ishii C (2008), Kitagawa K (2010), Kitagawa K (2010)	4
GATA3	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
PSMA3	1	MDM2	2	pull down	Xu H (2010)	1
MAPK14	0	SP1	0	affinity chromatography technology	Pan W (2008)	1
BRCA1	7	GATA3	2	affinity chromatography technology, affinity chromatography technology	Tkocz D (2012), Tkocz D (2012)	2
TCF7L2	12	GATA3	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Frietze S (2012), Frietze S (2012), Frietze S (2012)	3
GATA3	2	BMI1	0	affinity chromatography technology	Hosokawa H (2006)	1
USP21	2	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
GATA3	2	RARB	2	two hybrid	Ravasi T (2010)	1
GATA3	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
GATA3	2	TAL1	0	affinity chromatography technology	Ono Y (1998)	1
MDM2	2	SP1	0	affinity chromatography technology, affinity chromatography technology	Zerrouqi A (2012), Zerrouqi A (2012)	2
TBX21	1	GATA3	2	affinity chromatography technology, affinity chromatography technology	Chen GY (2006), Chen GY (2006)	2
BRCA1	7	WEE1	2	genetic interference	Shen JP (2017)	1
BMI1	0	REPIN1	3	affinity chromatography technology	Cao Q (2014)	1
HDAC3	5	REPIN1	3	affinity chromatography technology	Kim MY (2006)	1
FOXP3	1	GATA3	2	affinity chromatography technology	Zhang J (2013)	1
GATA3	2	LMO2	2	affinity chromatography technology	Ono Y (1998)	1