PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GCH1	0	MAP2K5	1	affinity chromatography technology	Chiarini A (2009)	1
PRKAR2B	1	PRKAR2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
GCH1	0	MAPK12	1	affinity chromatography technology, affinity chromatography technology	Chiarini A (2009), Chiarini A (2009)	2
CDC37	0	GCH1	0	two hybrid	Vinayagam A (2011)	1
GCH1	0	MAP2K4	3	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Chiarini A (2009), Chiarini A (2009)	2
RPH3A	7	GCH1	0	affinity chromatography technology	Imazumi K (1994)	1
GCH1	0	SP3	4	two hybrid	Swick L (2006)	1
GCH1	0	RAB26	0	two hybrid	Swick L (2006)	1
GCH1	0	CAMKK1	2	affinity chromatography technology	Chiarini A (2009)	1
MAP2K5	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
GCH1	0	YWHAZ	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
CDC37	0	HSPA8	4	affinity chromatography technology	Li J (2013)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
GCH1	0	CSNK2B	5	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	GCH1	0	two hybrid, biochemical, x-ray crystallography	Swick L (2006), Schoedon G (1989), Auerbach G (2000)	3
GCH1	0	CALML6	1	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	GIT2	2	two hybrid	Wang J (2011)	1
CDC37	0	AHSA1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
GCH1	0	PRKAR2A	0	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	ATP1B1	2	two hybrid	Swick L (2006)	1
GCH1	0	MAPK10	0	affinity chromatography technology, affinity chromatography technology	Chiarini A (2009), Chiarini A (2009)	2
GCH1	0	PACSIN3	2	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	PRKAR2B	1	affinity chromatography technology	Chiarini A (2009)	1
MAP2K5	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
GCH1	0	CNRIP1	0	two hybrid	Swick L (2006)	1
GCH1	0	CSNK1G1	0	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	CALML5	0	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	HSPA8	4	two hybrid	Swick L (2006)	1
GCH1	0	GCHFR	1	two hybrid	Swick L (2006)	1
SH3GL2	1	GCH1	0	two hybrid	Vinayagam A (2011)	1
GCH1	0	PPM1B	2	affinity chromatography technology	Chiarini A (2009)	1
GCH1	0	RLF	5	two hybrid	Swick L (2006)	1
GCH1	0	RGS19	1	affinity chromatography technology	Chiarini A (2009)	1
MAP2K4	3	MAPK10	0	enzymatic study, pull down, unspecified method	Ryoo K (2004), Ho DT (2003), Ho DT (2003)	3
OSBPL9	4	GCH1	0	affinity chromatography technology	Sowa ME (2009)	1
PACSIN3	2	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
GCH1	0	AHSA1	0	two hybrid, pull down	Swick L (2006), Swick L (2006)	2
AHSA1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Wolfgeher D (2015), Sun L (2012)	2